Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q15147-4 | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC … | Homo sapiens (Human) | 1194 aa |
Protein Details: Q15147-4 (PLCB4)
Protein Information
| Accession | Q15147-4 |
|---|---|
| Protein Names | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4) |
| Gene Symbol | PLCB4 |
| Organism | Homo sapiens (Human) |
| Length | 1194 aa |
| Isoforms | |
| Related PMIDs | 31251020 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAKPYEFNWQ11KEVPSFLQEG21AVFDRYEEES31FVFEPNCLFK41VDEFGFFLTW
51-10051RSEGKEGQVL61ECSLINSIRS71GAIPKDPKIL81AALEAVGKSE91NDLEGRIVCV
101-150101CSGTDLVNIS111FTYMVAENPE121VTKQWVEGLR131SIIHNFRANN141VSPMTCLKKH
151-200151WMKLAFMTNT161NGKIPVRSIT171RTFASGKTEK181VIFQALKELG191LPSGKNDEIE
201-250201PTAFSYEKFY211ELTQKICPRT221DIEDLFKKIN231GDKTDYLTVD241QLVSFLNEHQ
251-300251RDPRLNEILF261PFYDAKRAMQ271IIEMYEPDED281LKKKGLISSD291GFCRYLMSDE
301-350301NAPVFLDRLE311LYQEMDHPLA321HYFISSSHNT331YLTGRQFGGK341SSVEMYRQVL
351-400351LAGCRCVELD361CWDGKGEDQE371PIITHGKAMC381TDILFKDVIQ391AIKETAFVTS
401-450401EYPVILSFEN411HCSKYQQYKM421SKYCEDLFGD431LLLKQALESH441PLEPGRALPS
451-500451PNDLKRKILI461KNKRLKPEVE471KKQLEALRSM481MEAGESASPA491NILEDDNEEE
501-550501IESADQEEEA511HPEFKFGNEL521SADDLGHKEA531VANSVKKGLV541TVEDEQAWMA
551-600551SYKYVGATTN561IHPYLSTMIN571YAQPVKFQGF581HVAEERNIHY591NMSSFNESVG
601-650601LGYLKTHAIE611FVNYNKRQMS621RIYPKGGRVD631SSNYMPQIFW641NAGCQMVSLN
651-700651YQTPDLAMQL661NQGKFEYNGS671CGYLLKPDFM681RRPDRTFDPF691SETPVDGVIA
701-750701ATCSVQVISG711QFLSDKKIGT721YVEVDMYGLP731TDTIRKEFRT741RMVMNNGLNP
751-800751VYNEESFVFR761KVILPDLAVL771RIAVYDDNNK781LIGQRILPLD791GLQAGYRHIS
801-850801LRNEGNKPLS811LPTIFCNIVL821KTYVPDGFGD831IVDALSDPKK841FLSITEKRAD
851-900851QMRAMGIETS861DIADVPSDTS871KNDKKGKANT881AKANVTPQSS891SELRPTTTAA
901-950901LASGVEAKKG911IELIPQVRIE921DLKQMKAYLK931HLKKQQKELN941SLKKKHAKEH
951-1000951STMQKLHCTQ961VDKIVAQYDK971EKSTHEKILE981KAMKKKGGSN991CLEMKKETEI
1001-10501001KIQTLTSDHK1011SKVKEIVAQH1021TKEWSEMINT1031HSAEEQEIRD1041LHLSQQCELL
1051-11001051KKLLINAHEQ1061QTQQLKLSHD1071RESKEMRAHQ1081AKISMENSKA1091ISQDKSIKNK
1101-11501101AERERRVREL1111NSSNTKKFLE1121ERKRLAMKQS1131KEMDQLKKVQ1141LEHLEFLEKQ
1151-11941151NEQLLKSCHA1161VSQTQGEGDA1171ADGEIGSRDG1181PQTSNSSMKL1191QNAN
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 37 | PH domain-like PLC-beta, PH domain | - | - |
Deep-Palm: 0.14
|
|
| 62 | - | - | - |
Deep-Palm: 0.96
|
|
| 99 | - | - | - |
Deep-Palm: 0.83
|
|
| 101 | - | - | - |
Deep-Palm: 0.73
|
|
| 146 | - | - | - |
Deep-Palm: 0.08
|
|
| 217 | - | - | - |
Deep-Palm: 0.72
|
|
| 293 | - | - | - |
Deep-Palm: 0.95
|
|
| 354 | - | - | - |
Deep-Palm: 0.81
|
|
| 356 | - | - | - |
Deep-Palm: 0.73
|
|
| 361 | - | - | - |
Deep-Palm: 0.62
|
|
| 380 | - | - | - |
Deep-Palm: 0.77
|
|
| 412 | - | - | - |
Deep-Palm: 0.02
|
|
| 424 | - | - | - |
Deep-Palm: 0.70
|
|
| 644 | - | - | - |
Deep-Palm: 0.08
|
|
| 671 | - | - | - |
Deep-Palm: 0.83
|
|
| 703 | - | - | - |
Deep-Palm: 0.65
|
|
| 816 | - | - | - |
Deep-Palm: 0.90
|
|
| 958 | - | - | - |
Deep-Palm: 0.69
|
|
| 991 | - | - | - |
Deep-Palm: 0.89
|
|
| 1047 | - | - | - |
Deep-Palm: 0.91
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 99 | C → S | 0.002747 | SNP | Missense Mutation | LIHC |
| 101 | C → C | 0.001969 | SNP | Silent | LGG |
| 380 | C → S | 0.002033 | SNP | Missense Mutation | LUSC |
| 412 | C → R | 0.002033 | SNP | Missense Mutation | LUSC |
| 418 | Y → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 586 | R → C | 0.005013 | SNP | Missense Mutation | COAD |
| 621 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 644 | C → W | 0.002033 | SNP | Missense Mutation | LUSC |
| 651 | Y → C | 0.005587 | SNP | Missense Mutation | PCPG |
| 721 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 741 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 741 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 741 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 958 | C → F | 0.002506 | SNP | Missense Mutation | COAD |
| 1169 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 1169 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| ? | ? → ? | 0.027027 | SNP | Missense Mutation | DLBC |
| 424* | C → ? | 0.002033 | SNP | Nonsense Mutation | LUSC |