Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q15365 | PCBP1 | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous … | Homo sapiens (Human) | 356 aa |
Protein Details: Q15365 (PCBP1)
Protein Information
| Accession | Q15365 |
|---|---|
| Protein Names | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) |
| Gene Symbol | PCBP1 |
| Organism | Homo sapiens (Human) |
| Length | 356 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 31382980 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MDAGVTESGL11NVTLTIRLLM21HGKEVGSIIG31KKGESVKRIR41EESGARINIS
51-10051EGNCPERIIT61LTGPTNAIFK71AFAMIIDKLE81EDINSSMTNS91TAASRPPVTL
101-150101RLVVPATQCG111SLIGKGGCKI121KEIRESTGAQ131VQVAGDMLPN141STERAITIAG
151-200151VPQSVTECVK161QICLVMLETL171SQSPQGRVMT181IPYQPMPASS191PVICAGGQDR
201-250201CSDAAGYPHA211THDLEGPPLD221AYSIQGQHTI231SPLDLAKLNQ241VARQQSHFAM
251-300251MHGGTGFAGI261DSSSPEVKGY271WASLDASTQT281THELTIPNNL291IGCIIGRQGA
301-350301NINEIRQMSG311AQIKIANPVE321GSSGRQVTIT331GSAASISLAQ341YLINARLSSE
351-356351KGMGCS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 54 | SWISSPALM DBPTM CYSMODDB | KH domain |
SW480 cell line
(26865113)
|
cerebral cortex
(36430497)
LNCaP
(31251020)
|
Deep-Palm: 0.96
|
| 109 | SWISSPALM DBPTM CYSMODDB | KH domain | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.88
Deep-Palm: 0.96
|
| 118 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.89
|
|
| 158 | SWISSPALM DBPTM CYSMODDB | - |
SW480 cell line
(26865113)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.83
Deep-Palm: 0.84
|
| 163 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.73
Deep-Palm: 0.88
|
|
| 194 | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.45
|
|
| 201 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.53
|
|
| 293 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.55
|
|
| 355 | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.308
4
PC3
Specificity: 0.235
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.235
4/4 (100.0%)
2
HAP1 cell
Specificity: 0.118
2/2 (100.0%)
1
LNCaP
Specificity: 0.059
1/1 (100.0%)
1
U937 cell
Specificity: 0.059
1/1 (100.0%)
1
293T cell
Specificity: 0.059
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.235
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 54 | C → S | 0.002141 | SNP | Missense Mutation | SKCM |
| 355 | C → Vfs*11 | 0.002288 | INS | Frame Shift Ins | STAD |