Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q16518 | RPE65 | Retinoid isomerohydrolase (EC 3.1.1.64) (All-trans-retinyl-palmitate … | Homo sapiens (Human) | 533 aa |
Protein Details: Q16518 (RPE65)
Protein Information
| Accession | Q16518 |
|---|---|
| Protein Names | Retinoid isomerohydrolase (EC 3.1.1.64) (All-trans-retinyl-palmitate hydrolase) (Lutein isomerase) (Meso-zeaxanthin isomerase) (EC 5.3.3.22) (Retinal pigment epithelium-specific 65 kDa protein) (Retinol isomerase) |
| Gene Symbol | RPE65 |
| Organism | Homo sapiens (Human) |
| Length | 533 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSIQVEHPAG11GYKKLFETVE21ELSSPLTAHV31TGRIPLWLTG41SLLRCGPGLF
51-10051EVGSEPFYHL61FDGQALLHKF71DFKEGHVTYH81RRFIRTDAYV91RAMTEKRIVI
101-150101TEFGTCAFPD111PCKNIFSRFF121SYFRGVEVTD131NALVNVYPVG141EDYYACTETN
151-200151FITKINPETL161ETIKQVDLCN171YVSVNGATAH181PHIENDGTVY191NIGNCFGKNF
201-250201SIAYNIVKIP211PLQADKEDPI221SKSEIVVQFP231CSDRFKPSYV241HSFGLTPNYI
251-300251VFVETPVKIN261LFKFLSSWSL271WGANYMDCFE281SNETMGVWLH291IADKKRKKYL
301-350301NNKYRTSPFN311LFHHINTYED321NGFLIVDLCC331WKGFEFVYNY341LYLANLRENW
351-400351EEVKKNARKA361PQPEVRRYVL371PLNIDKADTG381KNLVTLPNTT391ATAILCSDET
401-450401IWLEPEVLFS411GPRQAFEFPQ421INYQKYCGKP431YTYAYGLGLN441HFVPDRLCKL
451-500451NVKTKETWVW461QEPDSYPSEP471IFVSHPDALE481EDDGVVLSVV491VSPGAGQKPA
501-533501YLLILNAKDL511SEVARAEVEI521NIPVTFHGLF531KKS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 45 | Carotenoid oxygenase | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.97
|
|
| 106 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.78
|
|
| 112 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.51
|
| 146 | DBPTM SWISSPALM | Retinal pigment epithelial membrane protein | - | - |
Deep-Palm: 0.87
|
| 169 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.58
|
|
| 195 | - | - | - |
Deep-Palm: 0.05
|
|
| 231 | DBPTM SWISSPALM | Retinal pigment epithelial membrane protein | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.62
|
| 278 | - | - | - |
Deep-Palm: 0.07
|
|
| 329 | DBPTM SWISSPALM | Retinal pigment epithelial membrane protein | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.06
|
| 330 | DBPTM SWISSPALM | Retinal pigment epithelial membrane protein | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.09
|
| 396 | - | - | - |
Deep-Palm: 0.92
|
|
| 427 | - | - | - |
Deep-Palm: 0.48
|
|
| 448 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.86
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 61 | F → C | 0.002288 | SNP | Missense Mutation | STAD |
| 309 | F → C | 0.002506 | SNP | Missense Mutation | COAD |
| 338 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 380 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 402 | W → C | 0.002033 | SNP | Missense Mutation | LUSC |