Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q16658 | FSCN1 | Fascin (55 kDa actin-bundling protein) … | Homo sapiens (Human) | 493 aa |
Protein Details: Q16658 (FSCN1)
Protein Information
| Accession | Q16658 |
|---|---|
| Protein Names | Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) |
| Gene Symbol | FSCN1 |
| Organism | Homo sapiens (Human) |
| Length | 493 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 29575903 29733200 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MTANGTAEAV11QIQFGLINCG21NKYLTAEAFG31FKVNASASSL41KKKQIWTLEQ
51-10051PPDEAGSAAV61CLRSHLGRYL71AADKDGNVTC81EREVPGPDCR91FLIVAHDDGR
101-150101WSLQSEAHRR111YFGGTEDRLS121CFAQTVSPAE131KWSVHIAMHP141QVNIYSVTRK
151-200151RYAHLSARPA161DEIAVDRDVP171WGVDSLITLA181FQDQRYSVQT191ADHRFLRHDG
201-250201RLVARPEPAT211GYTLEFRSGK221VAFRDCEGRY231LAPSGPSGTL241KAGKATKVGK
251-300251DELFALEQSC261AQVVLQAANE271RNVSTRQGMD281LSANQDEETD291QETFQLEIDR
301-350301DTKKCAFRTH311TGKYWTLTAT321GGVQSTASSK331NASCYFDIEW341RDRRITLRAS
351-400351NGKFVTSKKN361GQLAASVETA371GDSELFLMKL381INRPIIVFRG391EHGFIGCRKV
401-450401TGTLDANRSS411YDVFQLEFND421GAYNIKDSTG431KYWTVGSDSA441VTSSGDTPVD
451-493451FFFEFCDYNK461VAIKVGGRYL471KGDHAGVLKA481SAETVDPASL491WEY
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 19 | Actin-crosslinking | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.70
Deep-Palm: 0.66
|
|
| 61 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.97
|
|
| 80 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.83
|
|
| 89 | - | - | - |
Deep-Palm: 0.28
|
|
| 121 | SWISSPALM DBPTM CYSMODDB | Fascin domain | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.73
|
| 226 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.97
|
|
| 260 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(37611173)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.75
Deep-Palm: 0.97
|
| 305 | - | - | - |
Deep-Palm: 0.27
|
|
| 334 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.52
|
|
| 397 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.73
|
|
| 456 | - | - | - |
Deep-Palm: 0.61
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
cerebral cortex
Specificity: 0.308
4/4 (100.0%)
2
HAP1 cell
Specificity: 0.154
2/2 (100.0%)
1
HeLa cell
Specificity: 0.077
1/1 (100.0%)
1
EC cell
Specificity: 0.077
1/1 (100.0%)
1
293T cell
Specificity: 0.077
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.308
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 68 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 100 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 300 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 383 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 398 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 456 | C → C | 0.001014 | SNP | Silent | BRCA |
| 468 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 468 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 469 | Y → C | 0.002545 | SNP | Missense Mutation | GBM |