Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q16706 MAN2A1 Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi … Homo sapiens (Human) 1144 aa

Protein Details: Q16706 (MAN2A1)

Protein Information
AccessionQ16706
Protein NamesAlpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)
Gene SymbolMAN2A1
OrganismHomo sapiens (Human)
Length1144 aa
IsoformsNo isoforms
Related PMIDs 31251020
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MKLSRQFTVF11GSAIFCVVIF21SLYLMLDRGH31LDYPRNPRRE41GSFPQGQLSM
51-10051LQEKIDHLER61LLAENNEIIS71NIRDSVINLS81ESVEDGPKSS91QSNFSQGAGS
101-150101HLLPSQLSLS111VDTADCLFAS121QSGSHNSDVQ131MLDVYSLISF141DNPDGGVWKQ
151-200151GFDITYESNE161WDTEPLQVFV171VPHSHNDPGW181LKTFNDYFRD191KTQYIFNNMV
201-250201LKLKEDSRRK211FIWSEISYLS221KWWDIIDIQK231KDAVKSLIEN241GQLEIVTGGW
251-300251VMPDEATPHY261FALIDQLIEG271HQWLENNIGV281KPRSGWAIDP291FGHSPTMAYL
301-350301LNRAGLSHML311IQRVHYAVKK321HFALHKTLEF331FWRQNWDLGS341VTDILCHMMP
351-400351FYSYDIPHTC361GPDPKICCQF371DFKRLPGGRF381GCPWGVPPET391IHPGNVQSRA
401-450401RMLLDQYRKK411SKLFRTKVLL421APLGDDFRYC431EYTEWDLQFK441NYQQLFDYMN
451-500451SQSKFKVKIQ461FGTLSDFFDA471LDKADETQRD481KGQSMFPVLS491GDFFTYADRD
501-550501DHYWSGYFTS511RPFYKRMDRI521MESHLRAAEI531LYYFALRQAH541KYKINKFLSS
551-600551SLYTALTEAR561RNLGLFQHHD571AITGTAKDWV581VVDYGTRLFH591SLMVLEKIIG
601-650601NSAFLLILKD611KLTYDSYSPD621TFLEMDLKQK631SQDSLPQKNI641IRLSAEPRYL
651-700651VVYNPLEQDR661ISLVSVYVSS671PTVQVFSASG681KPVEVQVSAV691WDTANTISET
701-750701AYEISFRAHI711PPLGLKVYKI721LESASSNSHL731ADYVLYKNKV741EDSGIFTIKN
751-800751MINTEEGITL761ENSFVLLRFD771QTGLMKQMMT781KEDGKHHEVN791VQFSWYGTTI
801-850801KRDKSGAYLF811LPDGNAKPYV821YTTPPFVRVT831HGRIYSEVTC841FFDHVTHRVR
851-900851LYHIQGIEGQ861SVEVSNIVDI871RKVYNREIAM881KISSDIKSQN891RFYTDLNGYQ
901-950901IQPRMTLSKL911PLQANVYPMT921TMAYIQDAKH931RLTLLSAQSL941GVSSLNSGQI
951-1000951EVIMDRRLMQ961DDNRGLEQGI971QDNKITANLF981RILLEKRSAV991NTEEEKKSVS
1001-10501001YPSLLSHITS1011SLMNHPVIPM1021ANKFSSPTLE1031LQGEFSPLQS1041SLPCDIHLVN
1051-11001051LRTIQSKVGN1061GHSNEAALIL1071HRKGFDCRFS1081SKGTGLFCST1091TQGKILVQKL
1101-11441101LNKFIVESLT1111PSSLSLMHSP1121PGTQNISEIN1131LSPMEISTFR1141IQLR
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
16 - - -
Deep-Palm: 0.29
116 - - -
Deep-Palm: 0.88
346 - - -
Deep-Palm: 0.03
360 - - -
Deep-Palm: 0.03
367 - - -
Deep-Palm: 0.17
368 - - -
GPS-Palm: 0.66
Deep-Palm: 0.16
382 - - -
GPS-Palm: 0.71
Deep-Palm: 0.46
430 - - -
GPS-Palm: 0.66
Deep-Palm: 0.88
840 -
HeLa (37611173)
-
Deep-Palm: 0.14
1044 - - -
Deep-Palm: 0.90
1077 - - -
GPS-Palm: 0.77
Deep-Palm: 0.74
1088 - - -
GPS-Palm: 0.91
Deep-Palm: 0.90
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
LNCaP
Specificity: 1.000
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
33 Y → C 0.002427 SNP Missense Mutation BLCA
158 S → C 0.002427 SNP Missense Mutation BLCA
250 W → C 0.001764 SNP Missense Mutation LUAD
250 W → C 0.002033 SNP Missense Mutation LUSC
336 W → C 0.002033 SNP Missense Mutation LUSC
346 C → C 0.001887 SNP Silent UCEC
367 C → Y 0.002506 SNP Missense Mutation COAD
507 Y → C 0.017544 SNP Missense Mutation UCS
667 Y → C 0.001887 SNP Missense Mutation UCEC
736 Y → C 0.001969 SNP Missense Mutation HNSC
757 G → C 0.001887 SNP Missense Mutation UCEC
931 R → C 0.001887 SNP Missense Mutation UCEC
1089 S → C 0.002033 SNP Missense Mutation LUSC