Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q3ZCM7 | TUBB8 | Tubulin beta-8 chain (Tubulin beta … | Homo sapiens (Human) | 444 aa |
Protein Details: Q3ZCM7 (TUBB8)
Protein Information
| Accession | Q3ZCM7 |
|---|---|
| Protein Names | Tubulin beta-8 chain (Tubulin beta 8 class VIII) |
| Gene Symbol | TUBB8 |
| Organism | Homo sapiens (Human) |
| Length | 444 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 36430497 37611173 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.857
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
12
LNCaP cells
Specificity: 0.857
12/46 (26.1%)
2
Cerebral cortex
Specificity: 0.143
2/4 (50.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MREIVLTQIG11QCGNQIGAKF21WEVISDEHAI31DSAGTYHGDS41HLQLERINVY
51-10051YNEASGGRYV61PRAVLVDLEP71GTMDSVRSGP81FGQVFRPDNF91IFGQCGAGNN
101-150101WAKGHYTEGA111ELMESVMDVV121RKEAESCDCL131QGFQLTHSLG141GGTGSGMGTL
151-200151LLSKIREEYP161DRIINTFSIL171PSPKVSDTVV181EPYNATLSVH191QLIENADETF
201-250201CIDNEALYDI211CSKTLKLPTP221TYGDLNHLVS231ATMSGVTTCL241RFPGQLNADL
251-300251RKLAVNMVPF261PRLHFFMPGF271APLTSRGSQQ281YRALTVAELT291QQMFDAKNMM
301-350301AACDPRHGRY311LTAAAIFRGR321MPMREVDEQM331FNIQDKNSSY341FADWLPNNVK
351-400351TAVCDIPPRG361LKMSATFIGN371NTAIQELFKR381VSEQFTAMFR391RKAFLHWYTG
401-444401EGMDEMEFTE411AESNMNDLVS421EYQQYQDATA431EEEEDEEYAE441EEVA
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 12 | Prediction (Medium) | - | - |
| 127 | Prediction (Low) | - | - |
| 239 | Prediction (High) | - | - |
| 303 | CYSMODDB SWISSPALM DBPTM Prediction (High) | Tubulin C-terminal domain | - |
| 354 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) | Tubulin C-terminal domain | 37611173 |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 46 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 62 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 77 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 95 | C → C | 0.002288 | SNP | Silent | STAD |
| 148 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 320 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 320 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 320 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 338 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 391 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |