Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q3ZCM7 | TUBB8 | Tubulin beta-8 chain (Tubulin beta … | Homo sapiens (Human) | 444 aa |
Protein Details: Q3ZCM7 (TUBB8)
Protein Information
| Accession | Q3ZCM7 |
|---|---|
| Protein Names | Tubulin beta-8 chain (Tubulin beta 8 class VIII) |
| Gene Symbol | TUBB8 |
| Organism | Homo sapiens (Human) |
| Length | 444 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MREIVLTQIG11QCGNQIGAKF21WEVISDEHAI31DSAGTYHGDS41HLQLERINVY
51-10051YNEASGGRYV61PRAVLVDLEP71GTMDSVRSGP81FGQVFRPDNF91IFGQCGAGNN
101-150101WAKGHYTEGA111ELMESVMDVV121RKEAESCDCL131QGFQLTHSLG141GGTGSGMGTL
151-200151LLSKIREEYP161DRIINTFSIL171PSPKVSDTVV181EPYNATLSVH191QLIENADETF
201-250201CIDNEALYDI211CSKTLKLPTP221TYGDLNHLVS231ATMSGVTTCL241RFPGQLNADL
251-300251RKLAVNMVPF261PRLHFFMPGF271APLTSRGSQQ281YRALTVAELT291QQMFDAKNMM
301-350301AACDPRHGRY311LTAAAIFRGR321MPMREVDEQM331FNIQDKNSSY341FADWLPNNVK
351-400351TAVCDIPPRG361LKMSATFIGN371NTAIQELFKR381VSEQFTAMFR391RKAFLHWYTG
401-444401EGMDEMEFTE411AESNMNDLVS421EYQQYQDATA431EEEEDEEYAE441EEVA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 12 | Tubulin/FtsZ, GTPase domain superfamily OS01G0282866 PROTEIN | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.06
|
|
| 95 | - | - | - |
Deep-Palm: 0.27
|
|
| 127 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.70
|
|
| 129 | - | - | - |
Deep-Palm: 0.83
|
|
| 201 | - | - | - |
Deep-Palm: 0.42
|
|
| 211 | - | - | - |
Deep-Palm: 0.77
|
|
| 239 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.97
|
|
| 303 | SWISSPALM DBPTM CYSMODDB | Tubulin C-terminal domain | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.94
Deep-Palm: 0.48
|
| 354 | SWISSPALM DBPTM CYSMODDB | Tubulin C-terminal domain | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.91
Deep-Palm: 0.79
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
2
cerebral cortex
Specificity: 0.400
2/2 (100.0%)
1
LNCaP
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
LNCaP cells (Mass)
Specificity: 0.200
1/4 (25.0%)
1
Cerebral Cortex (Mass)
Specificity: 0.200
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 46 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 62 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 77 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 95 | C → C | 0.002288 | SNP | Silent | STAD |
| 148 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 320 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 320 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 320 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 338 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 391 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |