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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q5H936 SERINC3 Serine incorporator 3 Homo sapiens (Human) 212 aa

Protein Details: Q5H936 (SERINC3)

Protein Information
AccessionQ5H936
Protein NamesSerine incorporator 3
Gene SymbolSERINC3
OrganismHomo sapiens (Human)
Length212 aa
IsoformsNo isoforms
Related PMIDs 31251020 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501EHQPRSGLLQ11SSLITLYTMY21LTWSAMSNEP31DRSCNPNLMS41FITRITAPTL
51-10051APGNSTAVVP61TPTPPSKSGS71LLDSDNFIGL81FVFVLCLLYS91SIRTSTNSQV
101-150101DKLTLSGSDS111VILGDTTTSG121ASDEEDGQPR131RAVDNEKEGV141QYSYSLFHLM
151-200151LCLASLYIMM161TLTSWYSPDA171KFQSMTSKWP181AVWVKISSSW191VCLLLYVWTL
201-212201VAPLVLTSRD211FS
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
34 SWISSPALM DBPTM CYSMODDB Serine incorporator (Serinc)
HeLa (29575903)
cerebral cortex (36430497)
Deep-Palm: 0.20
86 - - -
GPS-Palm: 0.69
Deep-Palm: 0.72
152 - - -
Deep-Palm: 0.09
192 - - -
Deep-Palm: 0.67
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
LNCaP
Specificity: 0.333
1/1 (100.0%)
1
PC3
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.333
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
148 S → C 0.002427 SNP Missense Mutation BLCA
148 S → C 0.001887 SNP Missense Mutation UCEC
190 W → C 0.002033 SNP Missense Mutation LUSC
248 C → C 0.002506 SNP Silent COAD
248 C → C 0.002020 SNP Silent PRAD
293 R → C 0.002141 SNP Missense Mutation SKCM
293 R → C 0.001887 SNP Missense Mutation UCEC
338 F → C 0.001887 SNP Missense Mutation UCEC
354 R → C 0.001014 SNP Missense Mutation BRCA
354 R → C 0.027027 SNP Missense Mutation DLBC
403 Y → C 0.001969 SNP Missense Mutation HNSC