Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q5JP53 | TUBB | Tubulin beta chain | Homo sapiens (Human) | 426 aa |
Protein Details: Q5JP53 (TUBB)
Protein Information
| Accession | Q5JP53 |
|---|---|
| Protein Names | Tubulin beta chain |
| Gene Symbol | TUBB |
| Organism | Homo sapiens (Human) |
| Length | 426 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 31251020 31382980 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MFWEVISDEH11GIDPTGTYHG21DSDLQLDRIS31VYYNEATGGK41YVPRAILVDL
51-10051EPGTMDSVRS61GPFGQIFRPD71NFVFGQSGAG81NNWAKGHYTE91GAELVDSVLD
101-150101VVRKEAESCD111CLQGFQLTHS121LGGGTGSGMG131TLLISKIREE141YPDRIMNTFS
151-200151VVPSPKVSDT161VVEPYNATLS171VHQLVENTDE181TYCIDNEALY191DICFRTLKLT
201-250201TPTYGDLNHL211VSATMSGVTT221CLRFPGQLNA231DLRKLAVNMV241PFPRLHFFMP
251-300251GFAPLTSRGS261QQYRALTVPE271LTQQVFDAKN281MMAACDPRHG291RYLTVAAVFR
301-350301GRMSMKEVDE311QMLNVQNKNS321SYFVEWIPNN331VKTAVCDIPP341RGLKMAVTFI
351-400351GNSTAIQELF361KRISEQFTAM371FRRKAFLHWY381TGEGMDEMEF391TEAESNMNDL
401-426401VSEYQQYQDA411TAEEEEDFGE421EAEEEA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 109 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.87
|
|
| 111 | - | - | - |
Deep-Palm: 0.91
|
|
| 183 | - | - | - |
Deep-Palm: 0.13
|
|
| 193 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.16
|
|
| 221 | - | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.90
Deep-Palm: 0.97
|
|
| 285 | - | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.95
Deep-Palm: 0.83
|
|
| 336 | SWISSPALM DBPTM CYSMODDB | Tubulin C-terminal domain | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.92
Deep-Palm: 0.70
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
cerebral cortex
Specificity: 0.308
4/4 (100.0%)
3
LNCaP
Specificity: 0.231
3/3 (100.0%)
1
U937 cell
Specificity: 0.077
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.077
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.308
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 233 | M → Cfs*14 | 0.002976 | DEL | Frame Shift Del | KIRC |
| 251 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |