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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q5JR08 RHOC Ras homolog family member C Homo sapiens (Human) 188 aa

Protein Details: Q5JR08 (RHOC)

Protein Information
AccessionQ5JR08
Protein NamesRas homolog family member C
Gene SymbolRHOC
OrganismHomo sapiens (Human)
Length188 aa
IsoformsNo isoforms
Related PMIDs 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAAIRKKLVI11VGDGACGKTC21LLIVFSKDQF31PEVYVPTVFE41NYIADIEVDG
51-10051KQVELALWDT61AGQEDYDRLR71PLSYPDTDVI81LMCFSIDSPD91SLENIPEKWT
101-150101PEVKHFCPNV111PIILVGNKKD121LRQDEHTRRE131LAKMKQEPVR141SEEGRDMANR
151-188151ISAFGYLECS161AKTKEGVREV171FEMATRAGLQ181VRKNKRRR
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
16 SWISSPALM DBPTM CYSMODDB Ras family P-loop containing nucleoside triphosphate hydrolase Transforming protein P21 ras signature Small GTPase Small GTPase Rho -
cerebral cortex (36430497)
GPS-Palm: 0.89
Deep-Palm: 0.98
20 P-loop containing nucleoside triphosphate hydrolase Transforming protein P21 ras signature Small GTPase Small GTPase Rho -
Unknown (32651440)
cerebral cortex (36430497)
GPS-Palm: 0.75
Deep-Palm: 0.97
83 - - -
Deep-Palm: 0.82
107 SWISSPALM DBPTM CYSMODDB Ras family -
Unknown (32651440)
cerebral cortex (36430497)
Deep-Palm: 0.97
159 - - -
GPS-Palm: 0.89
Deep-Palm: 0.96
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
2
LNCaP
Specificity: 0.222
2/2 (100.0%)
2
PC3
Specificity: 0.222
2/2 (100.0%)
2
cerebral cortex
Specificity: 0.222
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.333
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
20 C → Ffs*86 0.001969 INS Frame Shift Ins HNSC
20 C → C 0.001887 SNP Silent UCEC
42 Y → C 0.001014 SNP Missense Mutation BRCA
189 G → C 0.002294 SNP Missense Mutation OV