Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q5JTZ9 | AARS2; AARSL; KIAA1270 | Alanine--tRNA ligase, mitochondrial (EC 6.1.1.7) … | Homo sapiens (Human) | 985 aa |
Protein Details: Q5JTZ9 (AARS2)
Protein Information
| Accession | Q5JTZ9 |
|---|---|
| Protein Names | Alanine--tRNA ligase, mitochondrial (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS2) (EC 6.-.-.-) |
| Gene Symbol | AARS2; AARSL; KIAA1270 |
| Organism | Homo sapiens (Human) |
| Length | 985 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31382980 32944167 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.923
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.923
36/46 (78.3%)
2
PC3 cells
Specificity: 0.051
2/4 (50.0%)
1
U937 cells
Specificity: 0.026
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAASVAAAAR11RLRRAIRRSP21AWRGLSHRPL31SSEPPAAKAS41AVRAAFLNFF
51-10051RDRHGHRLVP61SASVRPRGDP71SLLFVNAGMN81QFKPIFLGTV91DPRSEMAGFR
101-150101RVANSQKCVR111AGGHHNDLED121VGRDLSHHTF131FEMLGNWAFG141GEYFKEEACN
151-200151MAWELLTQVY161GIPEERLWIS171YFDGDPKAGL181DPDLETRDIW191LSLGVPASRV
201-250201LSFGPQENFW211EMGDTGPCGP221CTEIHYDLAG231GVGAPQLVEL241WNLVFMQHNR
251-300251EADGSLQPLP261QRHVDTGMGL271ERLVAVLQGK281HSTYDTDLFS291PLLNAIQQGC
301-350301RAPPYLGRVG311VADEGRTDTA321YRVVADHIRT331LSVCISDGIF341PGMSGPPLVL
351-400351RRILRRAVRF361SMEILKAPPG371FLGSLVPVVV381ETLGDAYPEL391QRNSAQIANL
401-450401VSEDEAAFLA411SLERGRRIID421RTLRTLGPSD431MFPAEVAWSL441SLCGDLGLPL
451-500451DMVELMLEEK461GVQLDSAGLE471RLAQEEAQHR481ARQAEPVQKQ491GLWLDVHALG
501-550501ELQRQGVPPT511DDSPKYNYSL521RPSGSYEFGT531CEAQVLQLYT541EDGTAVASVG
551-600551KGQRCGLLLD561RTNFYAEQGG571QASDRGYLVR581AGQEDVLFPV591ARAQVCGGFI
601-650601LHEAVAPECL611RLGDQVQLHV621DEAWRLGCMA631KHTATHLLNW641ALRQTLGPGT
651-700651EQQGSHLNPE661QLRLDVTTQT671PLTPEQLRAV681ENTVQEAVGQ691DEAVYMEEVP
701-750701LALTAQVPGL711RSLDEVYPDP721VRVVSVGVPV731AHALDPASQA741ALQTSVELCC
751-800751GTHLLRTGAV761GDLVIIGDRQ771LSKGTTRLLA781VTGEQAQQAR791ELGQSLAQEV
801-850801KAATERLSLG811SRDVAEALRL821SKDIGRLIEA831VETAVMPQWQ841RRELLATVKM
851-900851LQRRANTAIR861KLQMGQAAKK871TQELLERHSK881GPLIVDTVSA891ESLSVLVKVV
901-950901RQLCEQAPST911SVLLLSPQPM921GKVLCACQVA931QGAMPTFTAE941AWALAVCSHM
951-985951GGKAWGSRVV961AQGTGSTTDL971EAALSIAQTY981ALSQL
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 300 | Prediction (Medium) | - | - |
| 334 | Prediction (Medium) | - | - |
| 443 | Prediction (Low) | - | - |
| 555 | Prediction (Medium) | - | - |
| 596 | Prediction (Low) | - | - |
| 609 | Prediction (Medium) | - | - |
| 749 | Prediction (Medium) | - | - |
| 750 | Prediction (Medium) | - | - |
| 904 | Prediction (Low) | - | - |
| 925 | Prediction (Low) | - | - |
| 927 | Prediction (Low) | - | - |
| 947 | Prediction (Low) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 67 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 122 | G → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 221 | C → Lfs*18 | 0.002545 | DEL | Frame Shift Del | GBM |
| 256 | L → Cfs*54 | 0.003559 | DEL | Frame Shift Del | KIRP |
| 322 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 351 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 351 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 355 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 586 | V → Cfs*5 | 0.002288 | DEL | Frame Shift Del | STAD |
| 625 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 728 | V → Cfs*33 | 0.002545 | DEL | Frame Shift Del | GBM |
| 728 | V → Cfs*33 | 0.001887 | DEL | Frame Shift Del | UCEC |
| 854 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |