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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q5JWD1 GNAS GNAS complex locus Homo sapiens (Human) 87 aa

Protein Details: Q5JWD1 (GNAS)

Protein Information
AccessionQ5JWD1
Protein NamesGNAS complex locus
Gene SymbolGNAS
OrganismHomo sapiens (Human)
Length87 aa
IsoformsNo isoforms
Related PMIDs 19137006 29575903 31251020 32944167 36430497
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MGCLGNSKTE11DQRNEEKAQR21EANKKIEKQL31QKDKQVYRAT41HRLLLLGAGE
51-8751SGKSTIVKQM61RILHVNGFNG71EGGEEDPQAA81RSNSDGI
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
3 SWISSPALM DBPTM CYSMODDB -
HeLa (29575903)
-
GPS-Palm: 0.98
Deep-Palm: 0.03
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.267
4
LNCaP
Specificity: 0.267
4/4 (100.0%)
4
PC3
Specificity: 0.267
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.267
4/4 (100.0%)
2
HeLa cell
Specificity: 0.133
2/2 (100.0%)
1
Jurkat T cell
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
16 R → C 0.002506 SNP Missense Mutation COAD
72 G → C 0.002033 SNP Missense Mutation LUSC
160 R → C 0.002288 SNP Missense Mutation STAD
160 R → C 0.001764 SNP Missense Mutation LUAD
160 R → C 0.002033 SNP Missense Mutation LUSC
160 R → C 0.005435 SNP Missense Mutation ESCA
165 R → C 0.002033 SNP Missense Mutation LUSC
165 R → C 0.001887 SNP Missense Mutation UCEC
166 F → C 0.007299 SNP Missense Mutation READ
201 R → C 0.001014 SNP Missense Mutation BRCA
201 R → C 0.010870 SNP Missense Mutation ACC
201 R → C 0.004577 SNP Missense Mutation STAD
201 R → C 0.001764 SNP Missense Mutation LUAD
201 R → C 0.010989 SNP Missense Mutation LIHC
201 R → C 0.005013 SNP Missense Mutation COAD
201 R → C 0.005435 SNP Missense Mutation ESCA
201 R → C 0.003460 SNP Missense Mutation CESC
201 R → C 0.022472 SNP Missense Mutation PAAD
232 R → C 0.001764 SNP Missense Mutation LUAD
265 R → C 0.002288 SNP Missense Mutation STAD
283 R → C 0.001887 SNP Missense Mutation UCEC
315 F → C 0.001887 SNP Missense Mutation UCEC
356 R → C 0.002288 SNP Missense Mutation STAD
356 R → C 0.001969 SNP Missense Mutation HNSC
356 R → C 0.005013 SNP Missense Mutation COAD
373 R → C 0.001887 SNP Missense Mutation UCEC
374 R → C 0.003774 SNP Missense Mutation UCEC
380 R → C 0.001887 SNP Missense Mutation UCEC
389 R → C 0.002141 SNP Missense Mutation SKCM
389 R → C 0.003774 SNP Missense Mutation UCEC
431 S → C 0.002033 SNP Missense Mutation LUSC
562 R → C 0.002141 SNP Missense Mutation SKCM
598 R → C 0.003774 SNP Missense Mutation UCEC
632 R → C 0.002288 SNP Missense Mutation STAD
660 R → C 0.002506 SNP Missense Mutation COAD
680 Y → C 0.001887 SNP Missense Mutation UCEC
? ? → ? 0.001764 SNP Missense Mutation LUAD
162* C → ? 0.002141 SNP Nonsense Mutation SKCM
? ? → ? 0.001887 SNP Missense Mutation UCEC