Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q5JWD1 | GNAS | GNAS complex locus | Homo sapiens (Human) | 87 aa |
Protein Details: Q5JWD1 (GNAS)
Protein Information
| Accession | Q5JWD1 |
|---|---|
| Protein Names | GNAS complex locus |
| Gene Symbol | GNAS |
| Organism | Homo sapiens (Human) |
| Length | 87 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 21076176 29575903 31251020 32944167 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.792
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
42
LNCaP cells
Specificity: 0.792
42/46 (91.3%)
4
Jurkat T cells
Specificity: 0.075
4/25 (16.0%)
4
PC3 cells
Specificity: 0.075
4/4 (100.0%)
2
DU145 cells
Specificity: 0.038
2/2 (100.0%)
1
HeLa cells
Specificity: 0.019
1/1 (100.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGCLGNSKTE11DQRNEEKAQR21EANKKIEKQL31QKDKQVYRAT41HRLLLLGAGE
51-8751SGKSTIVKQM61RILHVNGFNG71EGGEEDPQAA81RSNSDGI
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 3 | CYSMODDB SWISSPALM DBPTM Prediction (High) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 16 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 72 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 160 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 160 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 160 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 160 | R → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 165 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 165 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 166 | F → C | 0.007299 | SNP | Missense Mutation | READ |
| 201 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 201 | R → C | 0.010870 | SNP | Missense Mutation | ACC |
| 201 | R → C | 0.004577 | SNP | Missense Mutation | STAD |
| 201 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 201 | R → C | 0.010989 | SNP | Missense Mutation | LIHC |
| 201 | R → C | 0.005013 | SNP | Missense Mutation | COAD |
| 201 | R → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 201 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 201 | R → C | 0.022472 | SNP | Missense Mutation | PAAD |
| 232 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 265 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 283 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 315 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 356 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 356 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 356 | R → C | 0.005013 | SNP | Missense Mutation | COAD |
| 373 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 374 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 380 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 389 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 389 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 431 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 562 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 598 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 632 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 660 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 680 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| ? | ? → ? | 0.001764 | SNP | Missense Mutation | LUAD |
| 162* | C → ? | 0.002141 | SNP | Nonsense Mutation | SKCM |
| ? | ? → ? | 0.001887 | SNP | Missense Mutation | UCEC |