Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q5JWT2 | MED23 | Mediator of RNA polymerase II … | Homo sapiens (Human) | 1374 aa |
Protein Details: Q5JWT2 (MED23)
Protein Information
| Accession | Q5JWT2 |
|---|---|
| Protein Names | Mediator of RNA polymerase II transcription subunit 23 (Mediator complex subunit 23) |
| Gene Symbol | MED23 |
| Organism | Homo sapiens (Human) |
| Length | 1374 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501METQLQSIFE11EVVKTEVIEE21AFPGMFMDTP31EDEKTKLISC41LGAFRQFWGG
51-10051LSQESHEQCI61QWIVKFIHGQ71HSPKRISFLY81DCLAMAVETG91LLPPRLVCES
101-150101LINSDTLEWE111RTQLWALTFK121LVRKIIGGVD131YKGVRDLLKV141ILEKILTIPN
151-200151TVSSAVVQQL161LAAREVIAYI171LERNACLLPA181YFAVTEIRKL191YPEGKLPHWL
201-250201LGNLVSDFVD211TFRPTARINS221ICGRCSLLPV231VNNSGAICNS241WKLDPATLRF
251-300251PLKGLLPYDK261DLFEPQTALL271RYVLEQPYSR281DMVCNMLGLN291KQTLNIAQHK
301-350301QRCPVLEDQL311VDLVVYAMER321SETEEKFDDG331GTSQLLWQHL341SSQLIFFVLF
351-400351QFASFPHMVL361SLHQKLAGRG371LIKGRDHLMW381VLLQFISGSI391QKNALADFLP
401-450401VMKLFDLLYP411EKEYIPVPDI421NKPQSTHAFA431MTCIWIHLNR441KAQNDNSKLQ
451-500451IPIPHSLRLH461HEFLQQSLRN471KSLQMNDYKI481ALLCNAYSTN491SECFTLPMGA
501-550501LVETIYGNGI511MRIPLPGTNC521MASGSITPLP531MNLLDSLTVH541AKMSLIHSIA
551-600551TRVIKLAHAK561SSVALAPALV571ETYSRLLVYM581EIESLGIKGF591ISQLLPTVFK
601-650601SHAWGILHTL611LEMFSYRMHH621IQPHYRVQLL631SHLHTLAAVA641QTNQNQLHLC
651-700651VESTALRLIT661ALGSSEVQPQ671FTRFLSDPKT681VLSAESEELN691RALILTLARA
701-750701THVTDFFTGS711DSIQGTWCKD721ILQTIMSFTP731HNWASHTLSC741FPGPLQAFFK
751-800751QNNVPQESRF761NLKKNVEEEY771RKWKSMSNEN781DIITHFSMQG791SPPLFLCLLW
801-850801KMLLETDHIN811QIGYRVLERI821GARALVAHVR831TFADFLVYEF841STSAGGQQLN
851-900851KCIEILNDMV861WKYNIVTLDR871LILCLAMRSH881EGNEAQVCYF891IIQLLLLKPN
901-950901DFRNRVSDFV911KENSPEHWLQ921NDWHTKHMNY931HKKYPEKLYF941EGLAEQVDPP
951-1000951VQIQSPYLPI961YFGNVCLRFL971PVFDIVIHRF981LELLPVSKSL991ETLLDHLGGL
1001-10501001YKFHDRPVTY1011LYNTLHYYEM1021HLRDRAFLKR1031KLVHAIIGSL1041KDNRPQGWCL
1051-11001051SDTYLKCAMN1061AREENPWVPD1071DTYYCRLIGR1081LVDTMAGKSP1091GPFPNCDWRF
1101-11501101NEFPNPAAHA1111LHVTCVELMA1121LAVSGKEVGN1131ALLNVVLKSQ1141PLVPRENITA
1151-12001151WMNAIGLIIT1161ALPEPYWIVL1171HDRIVSVISS1181PSLTSETEWV1191GYPFRLFDFT
1201-12501201ACHQSYSEMS1211CSYTLALAHA1221VWHHSSIGQL1231SLIPKFLTEV1241LLPIVKTEFQ
1251-13001251LLYVYHLVGP1261FLQRFQQERT1271RCMIEIGVAF1281YDMLLNVDQC1291STHLNYMDPI
1301-13501301CDFLYHMKYM1311FTGDSVKEQV1321KKIICNLKPA1331LKLRLRFITH1341ISKMEPAAVP
1351-13741351PQAMNSGSPA1361PQSNQVPVSL1371PVTQ
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 40 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.92
|
|
| 59 | - | - | - |
Deep-Palm: 0.07
|
|
| 82 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.96
|
|
| 98 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.97
|
|
| 176 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.97
|
|
| 222 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.92
|
|
| 225 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.78
|
|
| 238 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.94
|
|
| 284 | - | - | - |
Deep-Palm: 0.60
|
|
| 303 | - | - | - |
Deep-Palm: 0.73
|
|
| 433 | - | - | - |
Deep-Palm: 0.11
|
|
| 484 | - | - | - |
Deep-Palm: 0.47
|
|
| 493 | - | - | - |
Deep-Palm: 0.76
|
|
| 520 | - | - | - |
Deep-Palm: 0.76
|
|
| 650 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.95
|
|
| 718 | - | - | - |
Deep-Palm: 0.10
|
|
| 740 | - | - | - |
Deep-Palm: 0.14
|
|
| 797 | - | - | - |
Deep-Palm: 0.40
|
|
| 852 | - | - | - |
Deep-Palm: 0.09
|
|
| 874 | SWISSPALM DBPTM CYSMODDB | Mediator complex subunit 23 | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.66
|
| 888 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.87
|
|
| 966 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.52
|
|
| 1049 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.67
|
|
| 1057 | - | - | - |
Deep-Palm: 0.07
|
|
| 1075 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.84
|
|
| 1096 | - | - | - |
Deep-Palm: 0.35
|
|
| 1115 | - | - | - |
Deep-Palm: 0.84
|
|
| 1202 | - | - | - |
Deep-Palm: 0.14
|
|
| 1211 | - | - | - |
Deep-Palm: 0.08
|
|
| 1272 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.38
|
|
| 1290 | - | - | - |
Deep-Palm: 0.02
|
|
| 1301 | - | - | - |
Deep-Palm: 0.02
|
|
| 1325 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
LNCaP
Specificity: 1.000
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 104 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 279 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 569 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 573 | Y → C | 0.002028 | SNP | Missense Mutation | BRCA |
| 644 | C → Y | 0.002747 | SNP | Missense Mutation | LIHC |
| 753 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 872 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 963 | F → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 1011 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 1051 | C → C | 0.001887 | SNP | Silent | UCEC |
| 1092 | W → Cfs*32 | 0.001014 | DEL | Frame Shift Del | BRCA |
| 1290 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 1328 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 1328 | R → C | 0.005660 | SNP | Missense Mutation | UCEC |