Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q5SQY0 TUBB8 Tubulin beta chain Homo sapiens (Human) 410 aa

Protein Details: Q5SQY0 (TUBB8)

Protein Information
AccessionQ5SQY0
Protein NamesTubulin beta chain
Gene SymbolTUBB8
OrganismHomo sapiens (Human)
Length410 aa
IsoformsNo isoforms
Related PMIDs 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MNMPSTPLAP11TTGTATCSWS21ASTCTTTRPA31VRPPSFPHRP41PGNAALPSLM
51-10051PSRPTQVAGQ61CGAGNNWAKG71HYTEGAELME81SVMDVVRKEA91ESCDCLQGFQ
101-150101LTHSLGGGTG111SGMGTLLLSK121IREEYPDRII131NTFSILPSPK141VSDTVVEPYN
151-200151ATLSVHQLIE161NADETFCIDN171EALYDICSKT181LKLPTPTYGD191LNHLVSATMS
201-250201GVTTCLRFPG211QLNADLRKLA221VNMVPFPRLH231FFMPGFAPLT241SRGSQQYRAL
251-300251TVAELTQQMF261DAKNMMAACD271PRHGRYLTAA281AIFRGRMPMR291EVDEQMFNIQ
301-350301DKNSSYFADW311LPNNVKTAVC321DIPPRGLKMS331ATFIGNNTAI341QELFKRVSEQ
351-400351FTAMFRRKAF361LHWYTGEGMD371EMEFTEAESN381MNDLVSEYQQ391YQDATAEEEE
401-410401DEEYAEEEVA
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
17 - - -
Deep-Palm: 0.59
24 - - -
GPS-Palm: 0.66
Deep-Palm: 0.46
61 - - -
Deep-Palm: 0.79
93 - - -
GPS-Palm: 0.68
Deep-Palm: 0.70
95 - - -
Deep-Palm: 0.83
167 - - -
Deep-Palm: 0.42
177 - - -
Deep-Palm: 0.77
205 - - -
GPS-Palm: 0.90
Deep-Palm: 0.97
269 SWISSPALM DBPTM CYSMODDB Tubulin C-terminal domain -
Unknown (32651440)
cerebral cortex (36430497)
GPS-Palm: 0.94
Deep-Palm: 0.48
320 SWISSPALM DBPTM CYSMODDB Tubulin C-terminal domain -
cerebral cortex (36430497)
GPS-Palm: 0.91
Deep-Palm: 0.79
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
2
cerebral cortex
Specificity: 0.400
2/2 (100.0%)
1
LNCaP
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
LNCaP cells (Mass)
Specificity: 0.200
1/4 (25.0%)
1
Cerebral Cortex (Mass)
Specificity: 0.200
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
46 R → C 0.002506 SNP Missense Mutation COAD
62 R → C 0.001764 SNP Missense Mutation LUAD
77 R → C 0.002288 SNP Missense Mutation STAD
95 C → C 0.002288 SNP Silent STAD
148 G → C 0.001764 SNP Missense Mutation LUAD
320 R → C 0.002506 SNP Missense Mutation COAD
320 R → C 0.002141 SNP Missense Mutation SKCM
320 R → C 0.001887 SNP Missense Mutation UCEC
338 S → C 0.001764 SNP Missense Mutation LUAD
391 R → C 0.001887 SNP Missense Mutation UCEC