Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q5SRN1 | CDC40 | Pre-mRNA-processing factor 17 (Cell division … | Homo sapiens (Human) | 539 aa |
Protein Details: Q5SRN1 (CDC40)
Protein Information
| Accession | Q5SRN1 |
|---|---|
| Protein Names | Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (PRP17 homolog) |
| Gene Symbol | CDC40 |
| Organism | Homo sapiens (Human) |
| Length | 539 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSAAIAALAA11SYGSGSGSES21DSDSESSRCP31LPAADSLMHL41TKSPSSKPSL
51-10051AVAVDSAPEV61AVKEDLETGV71HLDPAVKEVQ81YNPTYETMFA91PEFGPENPFR
101-150101TQQMAAPRNM111LSGYAEPAHI121NDFMFEQQRR131TFATYGYALD141PSLDNHQVSA
151-200151KYIGSVEEAE161KNQGLTVFET171GQKKTEKRKK181FKENDASNID191GFLGPWAKYV
201-250201DEKDVAKPSE211EEQKELDEIT221AKRQKKGKQE231EEKPGEEKTI241LHVKEMYDYQ
251-300251GRSYLHIPQD261VGVNLRSTMP271PEKCYLPKKQ281IHVWSGHTKG291VSAVRLFPLS
301-350301GHLLLSCSMD311CKIKLWEVYG321ERRCLRTFIG331HSKAVRDICF341NTAGTQFLSA
351-400351AYDRYLKLWD361TETGQCISRF371TNRKVPYCVK381FNPDEDKQNL391FVAGMSDKKI
401-450401VQWDIRSGEI411VQEYDRHLGA421VNTIVFVDEN431RRFVSTSDDK441SLRVWEWDIP
451-500451VDFKYIAEPS461MHSMPAVTLS471PNGKWLACQS481MDNQILIFGA491QNRFRLNKKK
501-539501IFKGHMVAGY511ACQVDFSPDM521RVPQSFQNLK531EVTAGPQEG
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 29 | - | - | - |
Deep-Palm: 0.94
|
|
| 274 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.48
|
|
| 307 | SWISSPALM DBPTM CYSMODDB | WD domain G-beta repeat | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.79
|
| 311 | SWISSPALM DBPTM CYSMODDB | WD domain G-beta repeat | - | - |
Deep-Palm: 0.57
|
| 324 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.73
|
|
| 339 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.49
|
|
| 366 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.65
|
|
| 378 | - | - | - |
Deep-Palm: 0.45
|
|
| 478 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.64
|
|
| 512 | - | - | - |
Deep-Palm: 0.26
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
LNCaP
Specificity: 0.750
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.250
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 12 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |
| 196 | W → C | 0.002288 | SNP | Missense Mutation | STAD |
| 247 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 249 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 323 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 433 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 435 | S → delinsKDHNSGKC | 0.002976 | INS | In Frame Ins | KIRC |
| 437 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 502 | F → C | 0.002506 | SNP | Missense Mutation | COAD |