Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q5TCI8 | LMNA | Prelamin-A/C | Homo sapiens (Human) | 491 aa |
Protein Details: Q5TCI8 (LMNA)
Protein Information
| Accession | Q5TCI8 |
|---|---|
| Protein Names | Prelamin-A/C |
| Gene Symbol | LMNA |
| Organism | Homo sapiens (Human) |
| Length | 491 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.923
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.923
36/46 (78.3%)
3
PC3 cells
Specificity: 0.077
3/4 (75.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MQPLLCLGNL11EDARERTGTL21LAQHPAWGRT31RAKPGSPLNT41KKEGDLIAAQ
51-10051ARLKDLEALL61NSKEAALSTA71LSEKRTLEGE81LHDLRGQVAK91LEAALGEAKK
101-150101QLQDEMLRRV111DAENRLQTMK121EELDFQKNIY131SEELRETKRR141HETRLVEIDN
151-200151GKQREFESRL161ADALQELRAQ171HEDQVEQYKK181ELEKTYSAKL191DNARQSAERN
201-250201SNLVGAAHEE211LQQSRIRIDS221LSAQLSQLQK231QLAAKEAKLR241DLEDSLARER
251-300251DTSRRLLAEK261EREMAEMRAR271MQQQLDEYQE281LLDIKLALDM291EIHAYRKLLE
301-350301GEEERLRLSP311SPTSQRSRGR321ASSHSSQTQG331GGSVTKKRKL341ESTESRSSFS
351-400351QHARTSGRVA361VEEVDEEGKF371VRLRNKSNED381QSMGNWQIKR391QNGDDPLLTY
401-450401RFPPKFTLKA411GQVVTIWAAG421AGATHSPPTD431LVWKAQNTWG441CGNSLRTALI
451-491451NSTGEEVAMR461KLVRSVTVVE471DDEDEDGDDL481LHHHHVSGSR491R
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 6 | Prediction (High) | - | - |
| 441 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 45 | Y → C | 0.003559 | SNP | Missense Mutation | KIRP |
| 156 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 216 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 329 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 376 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 388 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 401 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 527 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |