Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q5TCI8 | LMNA | Prelamin-A/C | Homo sapiens (Human) | 491 aa |
Protein Details: Q5TCI8 (LMNA)
Protein Information
| Accession | Q5TCI8 |
|---|---|
| Protein Names | Prelamin-A/C |
| Gene Symbol | LMNA |
| Organism | Homo sapiens (Human) |
| Length | 491 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MQPLLCLGNL11EDARERTGTL21LAQHPAWGRT31RAKPGSPLNT41KKEGDLIAAQ
51-10051ARLKDLEALL61NSKEAALSTA71LSEKRTLEGE81LHDLRGQVAK91LEAALGEAKK
101-150101QLQDEMLRRV111DAENRLQTMK121EELDFQKNIY131SEELRETKRR141HETRLVEIDN
151-200151GKQREFESRL161ADALQELRAQ171HEDQVEQYKK181ELEKTYSAKL191DNARQSAERN
201-250201SNLVGAAHEE211LQQSRIRIDS221LSAQLSQLQK231QLAAKEAKLR241DLEDSLARER
251-300251DTSRRLLAEK261EREMAEMRAR271MQQQLDEYQE281LLDIKLALDM291EIHAYRKLLE
301-350301GEEERLRLSP311SPTSQRSRGR321ASSHSSQTQG331GGSVTKKRKL341ESTESRSSFS
351-400351QHARTSGRVA361VEEVDEEGKF371VRLRNKSNED381QSMGNWQIKR391QNGDDPLLTY
401-450401RFPPKFTLKA411GQVVTIWAAG421AGATHSPPTD431LVWKAQNTWG441CGNSLRTALI
451-491451NSTGEEVAMR461KLVRSVTVVE471DDEDEDGDDL481LHHHHVSGSR491R
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 6 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.10
|
|
| 441 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.84
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
3
LNCaP
Specificity: 0.375
3/3 (100.0%)
3
PC3
Specificity: 0.375
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 0.250
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 45 | Y → C | 0.003559 | SNP | Missense Mutation | KIRP |
| 156 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 216 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 329 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 376 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 388 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 401 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 527 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |