Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q5VVL7 | DBT | Dihydrolipoamide acetyltransferase component of pyruvate … | Homo sapiens (Human) | 320 aa |
Protein Details: Q5VVL7 (DBT)
Protein Information
| Accession | Q5VVL7 |
|---|---|
| Protein Names | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.-) |
| Gene Symbol | DBT |
| Organism | Homo sapiens (Human) |
| Length | 320 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32651440 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAAVRMLRTW11SRNAGKLICV21RYFQTCGNVH31VLKPNYVCFF41GYPSFKYSHP
51-10051HHFLKTTAAL61RGQVVQFKLS71DIGEGIREVT81VKEWYVKEGD91TVSQFDSICE
101-150101VQSDKASVTI111TSRYDGVIKK121LYYNLDDIAY131VGKPLVDIET141EALKDSEEDV
151-200151VETPAVSHDE161HTHQEIKGRK171TLATPAVRRL181AMENNIKLSE191VVGSGKDGRI
201-250201LKEDILNYLE211KQTGAILPPS221PKVEIMPPPP231KPKDMTVPIL241VSKPPVFTGK
251-300251DKTEPIKGFQ261KAMVKTMSAA271LKIPHFGYCD281EIDLTELVKL291REELKPIAFA
301-320301RGIKLSFMPF311FLKYYFSWKS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 19 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.51
|
|
| 26 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.18
|
|
| 38 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.05
|
|
| 99 | - | - | - |
Deep-Palm: 0.37
|
|
| 279 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
LNCaP
Specificity: 0.667
4/4 (100.0%)
1
Jurkat T cell
Specificity: 0.167
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.167
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 61 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 462 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |