Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q68DH5 | LMBRD2 | G-protein coupled receptor-associated protein LMBRD2 … | Homo sapiens (Human) | 695 aa |
Protein Details: Q68DH5 (LMBRD2)
Protein Information
| Accession | Q68DH5 |
|---|---|
| Protein Names | G-protein coupled receptor-associated protein LMBRD2 (LMBR1 domain-containing protein 2) |
| Gene Symbol | LMBRD2 |
| Organism | Homo sapiens (Human) |
| Length | 695 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSGAALGLEI11VFVFFLALFL21LHRYGDFKKQ31HRLVIIGTLL41AWYLCFLIVF
51-10051ILPLDVSTTI61YNRCKHAAAN71SSPPENSNIT81GLYATANPVP91SQHPCFKPWS
101-150101YIPDGIMPIF111WRVVYWTSQF121LTWILLPFMQ131SYARSGGFSI141TGKIKTALIE
151-200151NAIYYGTYLL161IFGAFLIYVA171VNPHLHLEWN181QLQTIGIAAA191NTWGLFLLVL
201-250201LLGYGLVEIP211RSYWNGAKRG221YLLMKTYFKA231AKLMTEKADA241EENLEDAMEE
251-300251VRKVNESIKY261NHPLRKCVDT271ILKKCPTEYQ281EKMGRNMDDY291EDFDEKHSIY
301-350301PSEKSLVKLH311KQVIYSVQRH321RRTQVQWQIL331LEQAFYLEDV341AKNETSATHQ
351-400351FVHTFQSPEP361ENRFIQYFYN371PTFEWYWECL381LRPWFYKILA391VVLSIFSVIV
401-450401VWSECTFFST411TPVLSLFAVF421IQLAEKTYNY431IYIEIACFLS441IFFLSICVYS
451-500451TVFRIRVFNY461YYLASHHQTD471AYSLLFSGML481FCRLTPPLCL491NFLGLTHMDS
501-550501SISHKNTQPT511AYTSIMGSMK521VLSFIADGFY531IYYPMLVVIL541CIATYFSLGT
551-600551RCLNLLGFQQ561FMGDDDMTSD571LVNEGKELIR581KEKRKRQRQE591EGENRRREWK
601-650601ERYGHNREDS611TRNRNIHTDP621KESNFSDVNT631NRSAFKYTRA641NNRTERDRIE
651-695651LLQDAEPLDF661NAETFTDDPL671ESESGRYQPG681GRYLSMSRSD691IFNDV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 45 | LMBR1-like membrane protein | - | - |
Deep-Palm: 0.66
|
|
| 64 | - | - | - |
Deep-Palm: 0.47
|
|
| 95 | - | - | - |
Deep-Palm: 0.09
|
|
| 267 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.53
|
|
| 275 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.20
|
|
| 379 | - | - | - |
Deep-Palm: 0.04
|
|
| 405 | - | - | - |
Deep-Palm: 0.72
|
|
| 437 | - | - | - |
Deep-Palm: 0.12
|
|
| 447 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.05
|
|
| 482 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.52
|
|
| 489 | - | - | - |
Deep-Palm: 0.62
|
|
| 541 | - | - | - |
Deep-Palm: 0.57
|
|
| 552 | SWISSPALM DBPTM CYSMODDB | - | - | - |
Deep-Palm: 0.74
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
PC3
Specificity: 0.500
4/4 (100.0%)
3
LNCaP
Specificity: 0.375
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.125
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 14 | F → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 45 | C → C | 0.004283 | SNP | Silent | SKCM |
| 46 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 213 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 252 | R → C | 0.014599 | SNP | Missense Mutation | READ |
| 252 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 428 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 456 | R → C | 0.004283 | SNP | Missense Mutation | SKCM |
| 477 | S → C | 0.002288 | SNP | Missense Mutation | STAD |
| 551 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |