Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q6DFW0 | C9orf72 | Guanine nucleotide exchange factor C9orf72 … | Mus musculus (Mouse) | 481 aa |
Protein Details: Q6DFW0 (C9orf72)
Protein Information
| Accession | Q6DFW0 |
|---|---|
| Protein Names | Guanine nucleotide exchange factor C9orf72 homolog |
| Gene Symbol | C9orf72 |
| Organism | Mus musculus (Mouse) |
| Length | 481 aa |
| Isoforms | No isoforms |
| Related PMIDs | 34200797 |
| Database Sources | CysModDBdbPTM |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSTICPPPSP11AVAKTEIALS21GESPLLAATF31AYWDNILGPR41VRHIWAPKTD
51-10051QVLLSDGEIT61FLANHTLNGE71ILRNAESGAI81DVKFFVLSEK91GVIIVSLIFD
101-150101GNWNGDRSTY111GLSIILPQTE121LSFYLPLHRV131CVDRLTHIIR141KGRIWMHKER
151-200151QENVQKIVLE161GTERMEDQGQ171SIIPMLTGEV181IPVMELLASM191KSHSVPEDID
201-250201IADTVLNDDD211IGDSCHEGFL221LNAISSHLQT231CGCSVVVGSS241AEKVNKIVRT
251-300251LCLFLTPAER261KCSRLCEAES271SFKYESGLFV281QGLLKDATGS291FVLPFRQVMY
301-350301APYPTTHIDV311DVNTVKQMPP321CHEHIYNQRR331YMRSELTAFW341RATSEEDMAQ
351-400351DTIIYTDESF361TPDLNIFQDV371LHRDTLVKAF381LDQVFHLKPG391LSLRSTFLAQ
401-450401FLLILHRKAL411TLIKYIEDDT421QKGKKPFKSL431RNLKIDLDLT441AEGDLNIIMA
451-481451LAEKIKPGLH461SFIFGRPFYT471SVQERDVLMT481F
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 5 | - |
Brain
(34200797)
| - |
GPS-Palm: 0.95
Deep-Palm: 0.03
|
|
| 131 | - | - | - |
Deep-Palm: 0.85
|
|
| 215 | - | - | - |
Deep-Palm: 0.16
|
|
| 231 | - | - | - |
Deep-Palm: 0.78
|
|
| 233 | - | - | - |
Deep-Palm: 0.72
|
|
| 252 | SWISSPALM DBPTM CYSMODDB | C9orf72-like protein family |
Forebrain
(28680068)
| - |
GPS-Palm: 0.95
Deep-Palm: 0.95
|
| 262 | - | - | - |
Deep-Palm: 0.92
|
|
| 266 | - | - | - |
Deep-Palm: 0.90
|
|
| 321 | - | - | - |
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
Brain
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 272 | F → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 303 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |
| 329 | R → C | 0.002506 | SNP | Missense Mutation | COAD |