Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q6ICB0 | DESI1 | Desumoylating isopeptidase 1 (DeSI-1) (EC … | Homo sapiens (Human) | 168 aa |
Protein Details: Q6ICB0 (DESI1)
Protein Information
| Accession | Q6ICB0 |
|---|---|
| Protein Names | Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 2) (Palmitoyl protein thioesterase DESI1) (EC 3.1.2.22) (Polyubiquitinated substrate transporter) (POST) (S-depalmitoylase DESI1) |
| Gene Symbol | DESI1 |
| Organism | Homo sapiens (Human) |
| Length | 168 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEPPNLYPVK11LYVYDLSKGL21ARRLSPIMLG31KQLEGIWHTS41IVVHKDEFFF
51-10051GSGGISSCPP61GGTLLGPPDS71VVDVGSTEVT81EEIFLEYLSS91LGESLFRGEA
101-150101YNLFEHNCNT111FSNEVAQFLT121GRKIPSYITD131LPSEVLSTPF141GQALRPLLDS
151-168151IQIQPPGGSS161VGRPNGQS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 58 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.92
|
|
| 108 | - |
HeLa
(37611173)
| - |
Deep-Palm: 0.14
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 98 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 108 | C → C | 0.003460 | SNP | Silent | CESC |