Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q6IS14 | EIF5AL1 | Eukaryotic translation initiation factor 5A-1-like … | Homo sapiens (Human) | 154 aa |
Protein Details: Q6IS14 (EIF5AL1)
Protein Information
| Accession | Q6IS14 |
|---|---|
| Protein Names | Eukaryotic translation initiation factor 5A-1-like (eIF-5A-1-like) (eIF-5A1-like) (Eukaryotic initiation factor 5A isoform 1-like) |
| Gene Symbol | EIF5AL1 |
| Organism | Homo sapiens (Human) |
| Length | 154 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MADDLDFETG11DAGASATFPM21QCSALRKNGF31VVLKGWPCKI41VEMSASKTGK
51-10051HGHAKVHLVG61IDIFTGKKYE71DICPSTHNMD81VPNIKRNDFQ91LIGIQDGYLS
101-150101LLQDSGEVPE111DLRLPEGDLG121KEIEQKYDCG131EEILITVLSA141MTEEAAVAIK
151-154151AMAK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 22 | SWISSPALM DBPTM CYSMODDB | Translation initiation factor 5A-like N-terminal Translation initiation factor 5A-like, N-terminal Translation protein SH3-like domain superfamily Translation elongation factor IF5A-like Large ribosomal subunit protein uL2, domain 2 |
SW480 cell line
(26865113)
|
Unknown
(32651440)
|
GPS-Palm: 0.77
Deep-Palm: 0.97
|
| 38 | Translation elongation factor IF5A-like Translation elongation factor, IF5A, hypusine site Large ribosomal subunit protein uL2, domain 2 Translation initiation factor 5A-like, N-terminal Translation protein SH3-like domain superfamily | - | - |
Deep-Palm: 0.94
|
|
| 73 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.70
Deep-Palm: 0.46
|
|
| 129 | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
LNCaP
Specificity: 0.750
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.250
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 73 | C → Y | 0.001764 | SNP | Missense Mutation | LUAD |
| 73 | C → C | 0.002506 | SNP | Silent | COAD |
| 113 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 127 | Y → C | 0.002976 | SNP | Missense Mutation | KIRC |