Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q6L8Q7-2 | PDE12 | 2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC … | Homo sapiens (Human) | 535 aa |
Protein Details: Q6L8Q7-2 (PDE12)
Protein Information
| Accession | Q6L8Q7-2 |
|---|---|
| Protein Names | 2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4) |
| Gene Symbol | PDE12 |
| Organism | Homo sapiens (Human) |
| Length | 535 aa |
| Isoforms | |
| Related PMIDs | 31251020 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MWRLPGARAA11LRVIRTAVEK21LSRAEAGSQT31AAGAMERAVV41RCVPSEPKLS
51-10051LSFALADGSH61KNMQRDQSEP71LGRVLSRIAT81NALKGHAKAA91AAKKSRKSRP
101-150101NASGGAACSG111PGPEPAVFCE121PVVKLYYREE131AVAEDVLNVD141AWQDGAVLQI
151-200151GDVKYKVERN161PPAFTELQLP171RYIMAGFPVC181PKLSLEFGDP191ASSLFRWYKE
201-250201AKPGAAEPEV211GVPSSLSPSS221PSSSWTETDV231EERVYTPSNA241DIGLRLKLHC
251-300251TPGDGQRFGH261SRELESVCVV271EAGPGTCTFD281HRHLYTKKVT291EDALIRTVSY
301-350301NILADTYAQT311EFSRTVLYPY321CAPYALELDY331RQNLIQKELT341GYNADVICLQ
351-400351EVDRAVFSDS361LVPALEAFGL371EGVFRIKQHE381GLATFYRKSK391FSLLSQHDIS
401-450401FYEALESDPL411HKELLEKLVL421YPSAQEKVLQ431RSSVLQVSVL441QSTKDSSKRI
451-500451CVANTHLYWH461PKGGYIRLIQ471MAVALAHIRH481VSCDLYPGIP491VIFCGDFNST
501-535501PSTGMYHFVI511NGSIPEDHED521WASNGEGGFG531GNFLL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 42 | - | - | - |
Deep-Palm: 0.97
|
|
| 108 | - | - | - |
Deep-Palm: 0.90
|
|
| 119 | - | - | - |
Deep-Palm: 0.93
|
|
| 180 | - | - | - |
Deep-Palm: 0.96
|
|
| 250 | - | - | - |
Deep-Palm: 0.96
|
|
| 268 | - | - | - |
Deep-Palm: 0.85
|
|
| 277 | - | - | - |
Deep-Palm: 0.88
|
|
| 321 | - | - | - |
Deep-Palm: 0.61
|
|
| 348 | - | - | - |
Deep-Palm: 0.87
|
|
| 451 | - | - | - |
Deep-Palm: 0.68
|
|
| 483 | - | - | - |
Deep-Palm: 0.23
|
|
| 494 | - | - | - |
Deep-Palm: 0.03
|
|
| 530 | - | - | - |
Deep-Palm: 0.33
|
|
| 544 | - | - | - |
Deep-Palm: 0.31
|
|
| 559 | - | - | - |
Deep-Palm: 0.38
|
|
| 604 | - | - | - |
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
LNCaP
Specificity: 1.000
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 277 | C → S | 0.002427 | SNP | Missense Mutation | BLCA |
| 421 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 451 | C → Y | 0.002427 | SNP | Missense Mutation | BLCA |
| 467 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 467 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 497 | F → C | 0.002506 | SNP | Missense Mutation | COAD |
| 559* | C → ? | 0.002545 | SNP | Nonsense Mutation | GBM |