Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q6NVY1-2 | HIBCH | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) … | Homo sapiens (Human) | 338 aa |
Protein Details: Q6NVY1-2 (HIBCH)
Protein Information
| Accession | Q6NVY1-2 |
|---|---|
| Protein Names | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (HIB-CoA hydrolase) (HIBYL-CoA-H) |
| Gene Symbol | HIBCH |
| Organism | Homo sapiens (Human) |
| Length | 338 aa |
| Isoforms | |
| Related PMIDs | 31251020 33636221 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGQREMWRLM11SRFNAFKRTN21TILHHLRMSK31HTDAAEEVLL41EKKGCTGVIT
51-10051LNRPKFLNAL61TLNMIRQIYP71QLKKWEQDPE81TFLIIIKGAG91GKAFCAGGDI
101-150101RVISEAEKAK111QKIAPVFFRE121EYMLNNAVGS131CQKPYVALIH141GITMGGGVGL
151-200151SVHGQFRVAT161EKCLFAMPET171AIGLFPDVGG181GYFLPRLQGK191LGYFLALTGF
201-250201RLKGRDVYRA211GIATHFVDSE221KLAMLEEDLL231ALKSPSKENI241ASVLENYHTE
251-300251SKIDRDKSFI261LEEHMDKINS271CFSANTVEEI281IENLQQDGSS291FALEQLKVIN
301-338301KMSPTSLKIT311LRQLMEGSSK321TLQEVLTMEY331RLSQACMF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 45 | ClpP/crotonase-like domain superfamily | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.98
|
|
| 95 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.97
|
|
| 131 | - | - | - |
Deep-Palm: 0.59
|
|
| 163 | - | - | - |
Deep-Palm: 0.80
|
|
| 271 | - | - | - |
Deep-Palm: 0.22
|
|
| 336 | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
3
LNCaP
Specificity: 0.750
3/3 (100.0%)
1
heart
Specificity: 0.250
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 271 | C → Kfs*26 | 0.001887 | INS | Frame Shift Ins | UCEC |
| 376 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |