Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q6P2Q9 | PRPF8 | Pre-mRNA-processing-splicing factor 8 (220 kDa … | Homo sapiens (Human) | 2335 aa |
Protein Details: Q6P2Q9 (PRPF8)
Protein Information
| Accession | Q6P2Q9 |
|---|---|
| Protein Names | Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) |
| Gene Symbol | PRPF8 |
| Organism | Homo sapiens (Human) |
| Length | 2335 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 29733200 31251020 31382980 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAGVFPYRGP11GNPVPGPLAP21LPDYMSEEKL31QEKARKWQQL41QAKRYAEKRK
51-10051FGFVDAQKED61MPPEHVRKII71RDHGDMTNRK81FRHDKRVYLG91ALKYMPHAVL
101-150101KLLENMPMPW111EQIRDVPVLY121HITGAISFVN131EIPWVIEPVY141ISQWGSMWIM
151-200151MRREKRDRRH161FKRMRFPPFD171DEEPPLDYAD181NILDVEPLEA191IQLELDPEED
201-250201APVLDWFYDH211QPLRDSRKYV221NGSTYQRWQF231TLPMMSTLYR241LANQLLTDLV
251-300251DDNYFYLFDL261KAFFTSKALN271MAIPGGPKFE281PLVRDINLQD291EDWNEFNDIN
301-350301KIIIRQPIRT311EYKIAFPYLY321NNLPHHVHLT331WYHTPNVVFI341KTEDPDLPAF
351-400351YFDPLINPIS361HRHSVKSQEP371LPDDDEEFEL381PEFVEPFLKD391TPLYTDNTAN
401-450401GIALLWAPRP411FNLRSGRTRR421ALDIPLVKNW431YREHCPAGQP441VKVRVSYQKL
451-500451LKYYVLNALK461HRPPKAQKKR471YLFRSFKATK481FFQSTKLDWV491EVGLQVCRQG
501-550501YNMLNLLIHR511KNLNYLHLDY521NFNLKPVKTL531TTKERKKSRF541GNAFHLCREV
551-600551LRLTKLVVDS561HVQYRLGNVD571AFQLADGLQY581IFAHVGQLTG591MYRYKYKLMR
601-650601QIRMCKDLKH611LIYYRFNTGP621VGKGPGCGFW631AAGWRVWLFF641MRGITPLLER
651-700651WLGNLLARQF661EGRHSKGVAK671TVTKQRVESH681FDLELRAAVM691HDILDMMPEG
701-750701IKQNKARTIL711QHLSEAWRCW721KANIPWKVPG731LPTPIENMIL741RYVKAKADWW
751-800751TNTAHYNRER761IRRGATVDKT771VCKKNLGRLT781RLYLKAEQER791QHNYLKDGPY
801-850801ITAEEAVAVY811TTTVHWLESR821RFSPIPFPPL831SYKHDTKLLI841LALERLKEAY
851-900851SVKSRLNQSQ861REELGLIEQA871YDNPHEALSR881IKRHLLTQRA891FKEVGIEFMD
901-950901LYSHLVPVYD911VEPLEKITDA921YLDQYLWYEA931DKRRLFPPWI941KPADTEPPPL
951-1000951LVYKWCQGIN961NLQDVWETSE971GECNVMLESR981FEKMYEKIDL991TLLNRLLRLI
1001-10501001VDHNIADYMT1011AKNNVVINYK1021DMNHTNSYGI1031IRGLQFASFI1041VQYYGLVMDL
1051-11001051LVLGLHRASE1061MAGPPQMPND1071FLSFQDIATE1081AAHPIRLFCR1091YIDRIHIFFR
1101-11501101FTADEARDLI1111QRYLTEHPDP1121NNENIVGYNN1131KKCWPRDARM1141RLMKHDVNLG
1151-12001151RAVFWDIKNR1161LPRSVTTVQW1171ENSFVSVYSK1181DNPNLLFNMC1191GFECRILPKC
1201-12501201RTSYEEFTHK1211DGVWNLQNEV1221TKERTAQCFL1231RVDDESMQRF1241HNRVRQILMA
1251-13001251SGSTTFTKIV1261NKWNTALIGL1271MTYFREAVVN1281TQELLDLLVK1291CENKIQTRIK
1301-13501301IGLNSKMPSR1311FPPVVFYTPK1321ELGGLGMLSM1331GHVLIPQSDL1341RWSKQTDVGI
1351-14001351THFRSGMSHE1361EDQLIPNLYR1371YIQPWESEFI1381DSQRVWAEYA1391LKRQEAIAQN
1401-14501401RRLTLEDLED1411SWDRGIPRIN1421TLFQKDRHTL1431AYDKGWRVRT1441DFKQYQVLKQ
1451-15001451NPFWWTHQRH1461DGKLWNLNNY1471RTDMIQALGG1481VEGILEHTLF1491KGTYFPTWEG
1501-15501501LFWEKASGFE1511ESMKWKKLTN1521AQRSGLNQIP1531NRRFTLWWSP1541TINRANVYVG
1551-16001551FQVQLDLTGI1561FMHGKIPTLK1571ISLIQIFRAH1581LWQKIHESIV1591MDLCQVFDQE
1601-16501601LDALEIETVQ1611KETIHPRKSY1621KMNSSCADIL1631LFASYKWNVS1641RPSLLADSKD
1651-17001651VMDSTTTQKY1661WIDIQLRWGD1671YDSHDIERYA1681RAKFLDYTTD1691NMSIYPSPTG
1701-17501701VLIAIDLAYN1711LHSAYGNWFP1721GSKPLIQQAM1731AKIMKANPAL1741YVLRERIRKG
1751-18001751LQLYSSEPTE1761PYLSSQNYGE1771LFSNQIIWFV1781DDTNVYRVTI1791HKTFEGNLTT
1801-18501801KPINGAIFIF1811NPRTGQLFLK1821IIHTSVWAGQ1831KRLGQLAKWK1841TAEEVAALIR
1851-19001851SLPVEEQPKQ1861IIVTRKGMLD1871PLEVHLLDFP1881NIVIKGSELQ1891LPFQACLKVE
1901-19501901KFGDLILKAT1911EPQMVLFNLY1921DDWLKTISSY1931TAFSRLILIL1941RALHVNNDRA
1951-20001951KVILKPDKTT1961ITEPHHIWPT1971LTDEEWIKVE1981VQLKDLILAD1991YGKKNNVNVA
2001-20502001SLTQSEIRDI2011ILGMEISAPS2021QQRQQIAEIE2031KQTKEQSQLT2041ATQTRTVNKH
2051-21002051GDEIITSTTS2061NYETQTFSSK2071TEWRVRAISA2081ANLHLRTNHI2091YVSSDDIKET
2101-21502101GYTYILPKNV2111LKKFICISDL2121RAQIAGYLYG2131VSPPDNPQVK2141EIRCIVMVPQ
2151-22002151WGTHQTVHLP2161GQLPQHEYLK2171EMEPLGWIHT2181QPNESPQLSP2191QDVTTHAKIM
2201-22502201ADNPSWDGEK2211TIIITCSFTP2221GSCTLTAYKL2231TPSGYEWGRQ2241NTDKGNNPKG
2251-23002251YLPSHYERVQ2261MLLSDRFLGF2271FMVPAQSSWN2281YNFMGVRHDP2291NMKYELQLAN
2301-23352301PKEFYHEVHR2311PSHFLNFALL2321QEGEVYSADR2331EDLYA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 435 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.95
|
|
| 497 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.70
|
|
| 547 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.93
|
|
| 605 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.08
|
|
| 627 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.35
|
|
| 719 | - | - | - |
Deep-Palm: 0.76
|
|
| 772 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.98
|
|
| 956 | - | - | - |
Deep-Palm: 0.69
|
|
| 973 | - | - | - |
Deep-Palm: 0.30
|
|
| 1089 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.19
|
|
| 1133 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.11
|
|
| 1190 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.23
|
|
| 1194 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.12
|
|
| 1200 | - | - | - |
Deep-Palm: 0.07
|
|
| 1228 | - | - | - |
Deep-Palm: 0.44
|
|
| 1291 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.98
|
|
| 1594 | - | - | - |
Deep-Palm: 0.30
|
|
| 1626 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.39
|
|
| 1896 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.98
|
|
| 2116 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.87
|
|
| 2144 | - | - | - |
Deep-Palm: 0.11
|
|
| 2216 | SWISSPALM DBPTM CYSMODDB | PROCT (NUC072) domain |
HeLa
(29575903)
| - |
Deep-Palm: 0.72
|
| 2223 | SWISSPALM DBPTM CYSMODDB | PROCT (NUC072) domain |
HeLa
(29575903)
| - |
Deep-Palm: 0.80
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.375
3
LNCaP
Specificity: 0.375
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.250
2/2 (100.0%)
1
U937 cell
Specificity: 0.125
1/1 (100.0%)
1
HeLa cell
Specificity: 0.125
1/1 (100.0%)
1
293T cell
Specificity: 0.125
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 44 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 430 | W → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 497 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 498 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 603 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 642 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 934 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 1112 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1139 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1194 | C → C | 0.002506 | SNP | Silent | COAD |
| 1195 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1201 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 1201 | R → C | 0.001969 | SNP | Missense Mutation | LGG |
| 1224 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 1354 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 1382 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 1594 | C → R | 0.017544 | SNP | Missense Mutation | UCS |
| 1594 | C → R | 0.005618 | SNP | Missense Mutation | PAAD |
| 1715 | Y → C | 0.002545 | SNP | Missense Mutation | GBM |
| 1744 | R → C | 0.001969 | SNP | Missense Mutation | LGG |
| 1832 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 1839 | W → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1992 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 2143 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 2223 | C → G | 0.002545 | SNP | Missense Mutation | GBM |
| 2266 | R → C | 0.005587 | SNP | Missense Mutation | PCPG |