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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q6PEY2 TUBA3E Tubulin alpha-3E chain (EC 3.6.5.-) … Homo sapiens (Human) 450 aa

Protein Details: Q6PEY2 (TUBA3E)

Protein Information
AccessionQ6PEY2
Protein NamesTubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain]
Gene SymbolTUBA3E
OrganismHomo sapiens (Human)
Length450 aa
IsoformsNo isoforms
Related PMIDs 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MRECISIHVG11QAGVQIGNAC21WELYCLEHGI31QPDGQMPSDK41TIGGGDDSFN
51-10051TFFSETGAGK61HVPRAVFVDL71EPTVVDEVRT81GTYRQLFHPE91QLITGKEDAA
101-150101SNYARGHYTI111GKEIVDLVLD121RIRKLADLCT131GLQGFLIFHS141FGGGTGSGFA
151-200151SLLMERLSVD161YSKKSKLEFA171IYPAPQVSTA181VVEPYNSILT191THTTLEHSDC
201-250201AFMVDNEAIY211DICRRNLDIE221RPTYTNLNRL231IGQIVSSITA241SLRFDGALNV
251-300251DLTEFQTNLV261PYPRIHFPLA271TYAPVISAEK281AYHEQLSVAE291ITNACFEPAN
301-350301QMVKCDPRHG311KYMACCMLYR321GDVVPKDVNA331AIATIKTKRT341IQFVDWCPTG
351-400351FKVGINYQPP361TVVPGGDLAK371VQRAVCMLSN381TTAIAEAWAR391LVHKFDLMYA
401-450401KWAFVHWYVG411EGMEEGEFSE421AREDLAALEK431DCEEVGVDSV441EAEAEEGEAY
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
4 Tubulin/FtsZ, GTPase domain superfamily - -
GPS-Palm: 0.94
Deep-Palm: 0.03
20 Tubulin/FtsZ, GTPase domain superfamily Tubulin/FtsZ, GTPase domain OS01G0282866 PROTEIN - -
Deep-Palm: 0.40
25 Tubulin/FtsZ, GTPase domain superfamily Tubulin/FtsZ, GTPase domain OS01G0282866 PROTEIN Alpha tubulin - -
Deep-Palm: 0.19
129 - - -
GPS-Palm: 0.89
Deep-Palm: 0.74
200 - - -
Deep-Palm: 0.07
213 - - -
GPS-Palm: 0.79
Deep-Palm: 0.16
295 - -
cerebral cortex (36430497)
Unknown (32651440)
Deep-Palm: 0.24
305 - - -
Deep-Palm: 0.08
315 - - -
GPS-Palm: 0.68
Deep-Palm: 0.22
316 - - -
GPS-Palm: 0.91
Deep-Palm: 0.40
347 SWISSPALM DBPTM CYSMODDB Tubulin C-terminal domain -
cerebral cortex (36430497)
Unknown (32651440)
GPS-Palm: 0.85
Deep-Palm: 0.25
376 - -
cerebral cortex (36430497)
Unknown (32651440)
GPS-Palm: 0.92
Deep-Palm: 0.97
432 - - -
Deep-Palm: 0.97
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
cerebral cortex
Specificity: 0.500
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.500
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
79 R → C 0.007299 SNP Missense Mutation READ
79 R → C 0.001887 SNP Missense Mutation UCEC
129 C → S 0.002033 SNP Missense Mutation LUSC
229 R → C 0.002506 SNP Missense Mutation COAD
236 S → C 0.001014 SNP Missense Mutation BRCA
390 R → C 0.027027 SNP Missense Mutation DLBC
422 R → C 0.002506 SNP Missense Mutation COAD