Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q6PI48 | DARS2 | Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) … | Homo sapiens (Human) | 645 aa |
Protein Details: Q6PI48 (DARS2)
Protein Information
| Accession | Q6PI48 |
|---|---|
| Protein Names | Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) |
| Gene Symbol | DARS2 |
| Organism | Homo sapiens (Human) |
| Length | 645 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 29733200 31251020 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MYFPSWLSQL11YRGLSRPIRR21TTQPIWGSLY31RSLLQSSQRR41IPEFSSFVVR
51-10051TNTCGELRSS61HLGQEVTLCG71WIQYRRQNTF81LVLRDFDGLV91QVIIPQDESA
101-150101ASVKKILCEA111PVESVVQVSG121TVISRPAGQE131NPKMPTGEIE141IKVKTAELLN
151-200151ACKKLPFEIK161NFVKKTEALR171LQYRYLDLRS181FQMQYNLRLR191SQMVMKMREY
201-250201LCNLHGFVDI211ETPTLFKRTP221GGAKEFLVPS231REPGKFYSLP241QSPQQFKQLL
251-300251MVGGLDRYFQ261VARCYRDEGS271RPDRQPEFTQ281IDIEMSFVDQ291TGIQSLIEGL
301-350301LQYSWPNDKD311PVVVPFPTMT321FAEVLATYGT331DKPDTRFGMK341IIDISDVFRN
351-400351TEIGFLQDAL361SKPHGTVKAI371CIPEGAKYLK381RKDIESIRNF391AADHFNQEIL
401-450401PVFLNANRNW411NSPVANFIME421SQRLELIRLM431ETQEEDVVLL441TAGEHNKACS
451-500451LLGKLRLECA461DLLETRGVVL471RDPTLFSFLW481VVDFPLFLPK491EENPRELESA
501-550501HHPFTAPHPS511DIHLLYTEPK521KARSQHYDLV531LNGNEIGGGS541IRIHNAELQR
551-600551YILATLLKED561VKMLSHLLQA571LDYGAPPHGG581IALGLDRLIC591LVTGSPSIRD
601-645601VIAFPKSFRG611HDLMSNTPDS621VPPEELKPYH631IRVSKPTDSK641AERAH
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 54 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.85
|
|
| 69 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.91
|
|
| 108 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.95
|
|
| 152 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.98
|
|
| 202 | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.75
|
|
| 264 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.95
|
|
| 371 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.97
|
|
| 449 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.97
|
|
| 459 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.98
|
|
| 590 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
3
LNCaP
Specificity: 0.500
3/3 (100.0%)
1
HAP1 cell
Specificity: 0.167
1/1 (100.0%)
1
293T cell
Specificity: 0.167
1/1 (100.0%)
1
HUVECs
Specificity: 0.167
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 58 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 258 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |
| 355 | F → C | 0.017544 | SNP | Missense Mutation | UCS |
| 550 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 550 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 449* | C → ? | 0.007299 | SNP | Nonsense Mutation | READ |