Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q6PI48 DARS2 Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) … Homo sapiens (Human) 645 aa

Protein Details: Q6PI48 (DARS2)

Protein Information
Accession Q6PI48
Protein Names Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS)
Gene Symbol DARS2
Organism Homo sapiens (Human)
Length 645 aa
Isoforms No isoforms
Related PMIDs 24357059 29733200 31251020 32944167
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.773
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
34
LNCaP cells
Specificity: 0.773
34/46 (73.9%)
4
HAP1 cells
Specificity: 0.091
4/10 (40.0%)
4
293T cells
Specificity: 0.091
4/10 (40.0%)
1
PC3 cells
Specificity: 0.023
1/4 (25.0%)
1
Endothelial cells
Specificity: 0.023
1/2 (50.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MYFPSWLSQL11YRGLSRPIRR21TTQPIWGSLY31RSLLQSSQRR41IPEFSSFVVR
51-10051TNTCGELRSS61HLGQEVTLCG71WIQYRRQNTF81LVLRDFDGLV91QVIIPQDESA
101-150101ASVKKILCEA111PVESVVQVSG121TVISRPAGQE131NPKMPTGEIE141IKVKTAELLN
151-200151ACKKLPFEIK161NFVKKTEALR171LQYRYLDLRS181FQMQYNLRLR191SQMVMKMREY
201-250201LCNLHGFVDI211ETPTLFKRTP221GGAKEFLVPS231REPGKFYSLP241QSPQQFKQLL
251-300251MVGGLDRYFQ261VARCYRDEGS271RPDRQPEFTQ281IDIEMSFVDQ291TGIQSLIEGL
301-350301LQYSWPNDKD311PVVVPFPTMT321FAEVLATYGT331DKPDTRFGMK341IIDISDVFRN
351-400351TEIGFLQDAL361SKPHGTVKAI371CIPEGAKYLK381RKDIESIRNF391AADHFNQEIL
401-450401PVFLNANRNW411NSPVANFIME421SQRLELIRLM431ETQEEDVVLL441TAGEHNKACS
451-500451LLGKLRLECA461DLLETRGVVL471RDPTLFSFLW481VVDFPLFLPK491EENPRELESA
501-550501HHPFTAPHPS511DIHLLYTEPK521KARSQHYDLV531LNGNEIGGGS541IRIHNAELQR
551-600551YILATLLKED561VKMLSHLLQA571LDYGAPPHGG581IALGLDRLIC591LVTGSPSIRD
601-645601VIAFPKSFRG611HDLMSNTPDS621VPPEELKPYH631IRVSKPTDSK641AERAH
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
54 Prediction (Low) - -
69 Prediction (Medium) - -
108 Prediction (Low) - -
152 Prediction (High) - -
202 Prediction (Low) - -
264 Prediction (Low) - -
371 Prediction (High) - -
449 Prediction (High) - -
459 Prediction (Medium) - -
590 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
58 R → C 0.001887 SNP Missense Mutation UCEC
258 Y → C 0.002506 SNP Missense Mutation COAD
355 F → C 0.017544 SNP Missense Mutation UCS
550 R → C 0.002506 SNP Missense Mutation COAD
550 R → C 0.001887 SNP Missense Mutation UCEC
449* C → ? 0.007299 SNP Nonsense Mutation READ