Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q7KZF4 | SND1; TDRD11 | Staphylococcal nuclease domain-containing protein 1 … | Homo sapiens (Human) | 910 aa |
Protein Details: Q7KZF4 (SND1)
Protein Information
| Accession | Q7KZF4 |
|---|---|
| Protein Names | Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator) |
| Gene Symbol | SND1; TDRD11 |
| Organism | Homo sapiens (Human) |
| Length | 910 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 29575903 29733200 31251020 31382980 32944167 36430497 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.621
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.621
36/46 (78.3%)
10
HAP1 cells
Specificity: 0.172
10/10 (100.0%)
4
PC3 cells
Specificity: 0.069
4/4 (100.0%)
4
293T cells
Specificity: 0.069
4/10 (40.0%)
2
Jurkat T cells
Specificity: 0.034
2/25 (8.0%)
1
U937 cells
Specificity: 0.017
1/1 (100.0%)
1
Cerebral cortex
Specificity: 0.017
1/4 (25.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MASSAQSGGS11SGGPAVPTVQ21RGIIKMVLSG31CAIIVRGQPR41GGPPPERQIN
51-10051LSNIRAGNLA61RRAAATQPDA71KDTPDEPWAF81PAREFLRKKL91IGKEVCFTIE
101-150101NKTPQGREYG111MIYLGKDTNG121ENIAESLVAE131GLATRREGMR141ANNPEQNRLS
151-200151ECEEQAKAAK161KGMWSEGNGS171HTIRDLKYTI181ENPRHFVDSH191HQKPVNAIIE
201-250201HVRDGSVVRA211LLLPDYYLVT221VMLSGIKCPT231FRREADGSET241PEPFAAEAKF
251-300251FTESRLLQRD261VQIILESCHN271QNILGTILHP281NGNITELLLK291EGFARCVDWS
301-350301IAVYTRGAEK311LRAAERFAKE321RRLRIWRDYV331APTANLDQKD341KQFVAKVMQV
351-400351LNADAIVVKL361NSGDYKTIHL371SSIRPPRLEG381ENTQDKNKKL391RPLYDIPYMF
401-450401EAREFLRKKL411IGKKVNVTVD421YIRPASPATE431TVPAFSERTC441ATVTIGGINI
451-500451AEALVSKGLA461TVIRYRQDDD471QRSSHYDELL481AAEARAIKNG491KGLHSKKEVP
501-550501IHRVADISGD511TQKAKQFLPF521LQRAGRSEAV531VEYVFSGSRL541KLYLPKETCL
551-600551ITFLLAGIEC561PRGARNLPGL571VQEGEPFSEE581ATLFTKELVL591QREVEVEVES
601-650601MDKAGNFIGW611LHIDGANLSV621LLVEHALSKV631HFTAERSSYY641KSLLSAEEAA
651-700651KQKKEKVWAH661YEEQPVEEVM671PVLEEKERSA681SYKPVFVTEI691TDDLHFYVQD
701-750701VETGTQLEKL711MENMRNDIAS721HPPVEGSYAP731RRGEFCIAKF741VDGEWYRARV
751-800751EKVESPAKIH761VFYIDYGNRE771VLPSTRLGTL781SPAFSTRVLP791AQATEYAFAF
801-850801IQVPQDDDAR811TDAVDSVVRD821IQNTQCLLNV831EHLSAGCPHV841TLQFADSKGD
851-900851VGLGLVKEGL861VMVEVRKEKQ871FQKVITEYLN881AQESAKSARL891NLWRYGDFRA
901-910901DDADEFGYSR
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 31 | Prediction (High) | - | - |
| 96 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) | - | 29575903 |
| 228 | Prediction (Medium) | - | - |
| 296 | Prediction (Low) | - | - |
| 440 | Experimental CYSMODDB SWISSPALM DBPTM | - | 29575903 |
| 549 | Prediction (Low) | - | - |
| 560 | Prediction (High) | - | - |
| 736 | CYSMODDB SWISSPALM DBPTM Prediction (Low) | Tudor domain | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 275 | G → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 391 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 391 | R → C | 0.004219 | SNP | Missense Mutation | SARC |
| 438 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 465 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 560 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 715 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 746 | Y → C | 0.003559 | SNP | Missense Mutation | KIRP |
| 747 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 894 | R → C | 0.002288 | SNP | Missense Mutation | STAD |