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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme … Homo sapiens (Human) 689 aa

Protein Details: Q7L2J0 (MEPCE)

Protein Information
AccessionQ7L2J0
Protein Names7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog)
Gene SymbolMEPCE
OrganismHomo sapiens (Human)
Length689 aa
IsoformsNo isoforms
Related PMIDs 31382980
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MIEMAAEKEP11FLVPAPPPPL21KDESGGGGGP31TVPPHQEAAS41GELRGGTERG
51-10051PGRCAPSAGS61PAAAVGRESP71GAAATSSSGP81QAQQHRGGGP91QAQSHGEARL
101-150101SDPPGRAAPP111DVGEERRGGG121GTELGPPAPP131RPRNGYQPHR141PPGGGGGKRR
151-200151NSCNVGGGGG161GFKHPAFKRR171RRVNSDCDSV181LPSNFLLGGN191IFDPLNLNSL
201-250201LDEEVSRTLN211AETPKSSPLP221AKGRDPVEIL231IPKDITDPLS241LNTCTDEGHV
251-300251VLASPLKTGR261KRHRHRGQHH271QQQQAAGGSE281SHPVPPTAPL291TPLLHGEGAS
301-350301QQPRHRGQNR311DAPQPYELNT321AINCRDEVVS331PLPSALQGPS341GSLSAPPAAS
351-400351VISAPPSSSS361RHRKRRRTSS371KSEAGARGGG381QGSKEKGRGS391WGGRHHHHHP
401-450401LPAAGFKKQQ411RKFQYGNYCK421YYGYRNPSCE431DGRLRVLKPE441WFRGRDVLDL
451-500451GCNVGHLTLS461IACKWGPSRM471VGLDIDSRLI481HSARQNIRHY491LSEELRLPPQ
501-550501TLEGDPGAEG511EEGTTTVRKR521SCFPASLTAS531RGPIAAPQVP541LDGADTSVFP
551-600551NNVVFVTGNY561VLDRDDLVEA571QTPEYDVVLC581LSLTKWVHLN591WGDEGLKRMF
601-650601RRIYRHLRPG611GILVLEPQPW621SSYGKRKTLT631ETIYKNYYRI641QLKPEQFSSY
651-689651LTSPDVGFSS661YELVATPHNT671SKGFQRPVYL681FHKARSPSH
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
54 - - -
Deep-Palm: 0.96
153 - - -
GPS-Palm: 0.88
Deep-Palm: 0.71
177 - - -
GPS-Palm: 0.75
Deep-Palm: 0.91
244 - - -
Deep-Palm: 0.95
324 - - -
Deep-Palm: 0.90
419 - - -
GPS-Palm: 0.73
Deep-Palm: 0.11
429 - - -
GPS-Palm: 0.73
Deep-Palm: 0.20
452 - - -
Deep-Palm: 0.80
463 - - -
Deep-Palm: 0.94
522 - - -
GPS-Palm: 0.90
Deep-Palm: 0.97
580 - - -
Deep-Palm: 0.67
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
U937 cell
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
170 R → C 0.002294 SNP Missense Mutation OV
179 S → C 0.001014 SNP Missense Mutation BRCA
244 C → Sfs*13 0.002141 DEL Frame Shift Del SKCM
244 C → Y 0.006993 SNP Missense Mutation LAML
284 V → Cfs*154 0.002506 DEL Frame Shift Del COAD
353 S → C 0.003460 SNP Missense Mutation CESC
363 R → C 0.001014 SNP Missense Mutation BRCA
363 R → C 0.001969 SNP Missense Mutation HNSC
366 R → C 0.002141 SNP Missense Mutation SKCM
366 R → C 0.003460 SNP Missense Mutation CESC
394 R → C 0.001887 SNP Missense Mutation UCEC
433 R → C 0.007299 SNP Missense Mutation READ
484 R → C 0.002288 SNP Missense Mutation STAD
484 R → C 0.001887 SNP Missense Mutation UCEC
496 R → C 0.002506 SNP Missense Mutation COAD
598 R → C 0.002506 SNP Missense Mutation COAD