Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q7TPR4 | Actn1 | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin … | Mus musculus (Mouse) | 892 aa |
Protein Details: Q7TPR4 (Actn1)
Protein Information
| Accession | Q7TPR4 |
|---|---|
| Protein Names | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) |
| Gene Symbol | Actn1 |
| Organism | Mus musculus (Mouse) |
| Length | 892 aa |
| Isoforms | No isoforms |
| Related PMIDs | 28526873 29733200 31311849 34200797 34884899 35358180 35477839 37925639 29217618 (mass) 31311849 (mass) 31772009 (mass) 34884899 (mass) 35358180 (mass) 37925639 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MDHYDSQQTN11DYMQPEEDWD21RDLLLDPAWE31KQQRKTFTAW41CNSHLRKAGT
51-10051QIENIEEDFR61DGLKLMLLLE71VISGERLAKP81ERGKMRVHKI91SNVNKALDFI
101-150101ASKGVKLVSI111GAEEIVDGNV121KMTLGMIWTI131ILRFAIQDIS141VEETSAKEGL
151-200151LLWCQRKTAP161YKNVNIQNFH171ISWKDGLGFC181ALIHRHRPEL191IDYGKLRKDD
201-250201PLTNLNTAFD211VAERFLDIPK221MLDAEDIVGT231ARPDEKAIMT241YVSSFYHAFS
251-300251GAQKAETAAN261RICKVLAVNQ271ENEQLMEDYE281KLASDLLEWI291RRTIPWLENR
301-350301VPENTMHAMQ311QKLEDFRDYR321RLHKPPKVQE331KCQLEINFNT341LQTKLRLSNR
351-400351PAFMPSEGRM361VSDINNAWGC371LEQAEKGYEE381WLLNEIRRLE391RLDHLAEKFR
401-450401QKASIHEAWT411DGKEAMLRQK421DYETATLSEI431KALLKKHEAF441ESDLAAHQDR
451-500451VEQIAAIAQE461LNELDYYDSP471SVNARCQKIC481DQWDNLGALT491QKRREALERT
501-550501EKLLETIDQL511YLEYAKRAAP521FNNWMEGAME531DLQDTFIVHT541IEEIQGLTTA
551-600551HEQFKATLPD561ADKERLAILG571IHNEVSKIVQ581TYHVNMAGTN591PYTTITPQEI
601-650601NGKWDHVRQL611VPRRDQALTE621EHARQQHNER631LRKQFGAQAN641VIGPWIQTKM
651-700651EEIGRISIEM661HGTLEDQLSH671LRQYEKSIVN681YKPKIDQLEC691DHQLIQEALI
701-750701FDNKHTNYNM711EHIRVGWEQL721LTTIARTINE731VENQILTRDA741KGISQEQMNE
751-800751FRASFNHFDR761DHSGTLGPEE771FKACLISLGY781DIGNDPQGEA791EFARIMSIVD
801-850801PNRLGVVTFQ811AFIDFMSRET821ADTDTADQVM831ASFKILAGDK841NYITEDELRR
851-892851ELPPDQAEYC861IARMAPYAGP871DSVPGALDYM881SFSTALYGES891DL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 41 | Calponin homology (CH) domain CH domain superfamily Calponin homology domain |
Brain
(31311849)
|
Brain
(35358180)
Brain
(31311849)
|
Deep-Palm: 0.73
|
|
| 154 | SWISSPALM DBPTM CYSMODDB | Calponin homology (CH) domain |
Liver
(28526873)
|
Brain
(35358180)
|
GPS-Palm: 0.96
Deep-Palm: 0.96
|
| 180 | SWISSPALM DBPTM CYSMODDB | Calponin homology (CH) domain |
Brain
(31311849)
|
Brain
(35358180)
Brain
(31311849)
|
GPS-Palm: 0.91
Deep-Palm: 0.71
|
| 263 | - | - | - |
Deep-Palm: 0.84
|
|
| 332 | - |
Brain
(31311849)
| - |
Deep-Palm: 0.88
|
|
| 370 | - | - | - |
Deep-Palm: 0.64
|
|
| 476 | - | - | - |
Deep-Palm: 0.24
|
|
| 480 | Spectrin repeat |
Brain
(31311849)
|
Brain
(35358180)
Brain
(31311849)
|
Deep-Palm: 0.42
|
|
| 690 | - |
Brain
(31311849)
|
Brain
(35358180)
Brain
(31311849)
|
Deep-Palm: 0.32
|
|
| 774 | - | - | - |
Deep-Palm: 0.83
|
|
| 860 | Ca2+ insensitive EF hand |
Brain
(34200797)
|
Brain
(31311849)
|
Deep-Palm: 0.95
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.455
5
Liver
Specificity: 0.139
5/5 (100.0%)
5
Brain
Specificity: 0.139
5/5 (100.0%)
1
Testis
Specificity: 0.028
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.920
23
Brain tissue (Mass)
Specificity: 0.639
23/56 (41.1%)
2
Liver tissue (Mass)
Specificity: 0.056
2/8 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.