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UniProt ID Gene Symbol Protein Name Organism Length Action
Q86T13 CLEC14A C-type lectin domain family 14 … Homo sapiens (Human) 490 aa

Protein Details: Q86T13 (CLEC14A)

Protein Information
AccessionQ86T13
Protein NamesC-type lectin domain family 14 member A (Epidermal growth factor receptor 5) (EGFR-5)
Gene SymbolCLEC14A
OrganismHomo sapiens (Human)
Length490 aa
IsoformsNo isoforms
Related PMIDs 24357059
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MRPAFALCLL11WQALWPGPGG21GEHPTADRAG31CSASGACYSL41HHATMKRQAA
51-10051EEACILRGGA61LSTVRAGAEL71RAVLALLRAG81PGPGGGSKDL91LFWVALERRR
101-150101SHCTLENEPL111RGFSWLSSDP121GGLESDTLQW131VEEPQRSCTA141RRCAVLQATG
151-200151GVEPAGWKEM161RCHLRANGYL171CKYQFEVLCP181APRPGAASNL191SYRAPFQLHS
201-250201AALDFSPPGT211EVSALCRGQL221PISVTCIADE231IGARWDKLSG241DVLCPCPGRY
251-300251LRAGKCAELP261NCLDDLGGFA271CECATGFELG281KDGRSCVTSG291EGQPTLGGTG
301-350301VPTRRPPATA311TSPVPQRTWP321IRVDEKLGET331PLVPEQDNSV341TSIPEIPRWG
351-400351SQSTMSTLQM361SLQAESKATI371TPSGSVISKF381NSTTSSATPQ391AFDSSSAVVF
401-450401IFVSTAVVVL411VILTMTVLGL421VKLCFHESPS431SQPRKESMGP441PGLESDPEPA
451-490451ALGSSSAHCT461NNGVKVGDCD471LRDRAEGALL481AESPLGSSDA
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
8 - - -
GPS-Palm: 0.75
Deep-Palm: 0.06
31 - - -
Deep-Palm: 0.78
37 - - -
Deep-Palm: 0.81
54 - - -
GPS-Palm: 0.87
Deep-Palm: 0.82
103 - - -
GPS-Palm: 0.87
Deep-Palm: 0.88
138 - - -
GPS-Palm: 0.69
Deep-Palm: 0.82
143 - - -
Deep-Palm: 0.75
162 - - -
Deep-Palm: 0.67
171 - - -
Deep-Palm: 0.60
179 - - -
Deep-Palm: 0.82
216 - - -
GPS-Palm: 0.65
Deep-Palm: 0.96
226 - - -
GPS-Palm: 0.74
Deep-Palm: 0.90
244 - - -
GPS-Palm: 0.88
Deep-Palm: 0.89
246 - - -
GPS-Palm: 0.88
Deep-Palm: 0.86
256 - - -
Deep-Palm: 0.82
262 - - -
Deep-Palm: 0.43
271 - - -
GPS-Palm: 0.69
Deep-Palm: 0.40
273 - - -
GPS-Palm: 0.81
Deep-Palm: 0.31
286 - - -
GPS-Palm: 0.78
Deep-Palm: 0.75
424 - - -
Deep-Palm: 0.93
459 - - -
Deep-Palm: 0.88
469 - - -
Deep-Palm: 0.92
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
HUVECs
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
93 W → C 0.001887 SNP Missense Mutation UCEC
137 S → C 0.001014 SNP Missense Mutation BRCA
143 C → F 0.001764 SNP Missense Mutation LUAD
143 C → C 0.002506 SNP Silent COAD
143 C → C 0.001887 SNP Silent UCEC
162 C → C 0.002506 SNP Silent COAD
165 R → C 0.002506 SNP Missense Mutation COAD
171 C → C 0.002033 SNP Silent LUSC
193 R → C 0.004283 SNP Missense Mutation SKCM
226 C → F 0.001969 SNP Missense Mutation HNSC
240 G → C 0.001969 SNP Missense Mutation HNSC
244 C → Y 0.001764 SNP Missense Mutation LUAD
244 C → C 0.007299 SNP Silent READ
246 C → C 0.002506 SNP Silent COAD
252 R → C 0.002020 SNP Missense Mutation PRAD
256 C → C 0.001887 SNP Silent UCEC
273 C → Y 0.002747 SNP Missense Mutation LIHC
305 R → C 0.002288 SNP Missense Mutation STAD
305 R → C 0.005618 SNP Missense Mutation PAAD
442 G → C 0.002033 SNP Missense Mutation LUSC