Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q86UE4 | MTDH | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated … | Homo sapiens (Human) | 582 aa |
Protein Details: Q86UE4 (MTDH)
Protein Information
| Accession | Q86UE4 |
|---|---|
| Protein Names | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) |
| Gene Symbol | MTDH |
| Organism | Homo sapiens (Human) |
| Length | 582 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 22496122 24357059 25914232 26111759 29575903 29733200 31251020 31382980 32651440 32944167 33636221 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAARSWQDEL11AQQAEEGSAR21LREMLSVGLG31FLRTELGLDL41GLEPKRYPGW
51-10051VILVGTGALG61LLLLFLLGYG71WAAACAGARK81KRRSPPRKRE91EAAAVPAAAP
101-150101DDLALLKNLR111SEEQKKKNRK121KLSEKPKPNG131RTVEVAEGEA141VRTPQSVTAK
151-200151QPPEIDKKNE161KSKKNKKKSK171SDAKAVQNSS181RHDGKEVDEG191AWETKISHRE
201-250201KRQQRKRDKV211LTDSGSLDST221IPGIENTITV231TTEQLTTASF241PVGSKKNKGD
251-300251SHLNVQVSNF261KSGKGDSTLQ271VSSGLNENLT281VNGGGWNEKS291VKLSSQISAG
301-350301EEKWNSVSPA311SAGKRKTEPS321AWSQDTGDAN331TNGKDWGRSW341SDRSIFSGIG
351-400351STAEPVSQST361TSDYQWDVSR371NQPYIDDEWS381GLNGLSSADP391NSDWNAPAEE
401-450401WGNWVDEERA411SLLKSQEPIP421DDQKVSDDDK431EKGEGALPTG441KSKKKKKKKK
451-500451KQGEDNSTAQ461DTEELEKEIR471EDLPVNTSKT481RPKQEKAFSL491KTISTSDPAE
501-550501VLVKNSQPIK511TLPPATSTEP521SVILSKSDSD531KSSSQVPPIL541QETDKSKSNT
551-582551KQNSVPPSQT561KSETSWESPK571QIKKKKKARR581ET
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 75 | SWISSPALM | Lysine-rich CEACAM1 co-isolated protein family | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.99
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.250
8
Jurkat T cell
Specificity: 0.250
8/8 (100.0%)
4
LNCaP
Specificity: 0.125
4/4 (100.0%)
4
Primary T cell
Specificity: 0.125
4/4 (100.0%)
4
PC3
Specificity: 0.125
4/4 (100.0%)
3
CEM 174 cell
Specificity: 0.094
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.062
2/2 (100.0%)
2
HeLa cell
Specificity: 0.062
2/2 (100.0%)
1
U937 cell
Specificity: 0.031
1/1 (100.0%)
1
EC cell
Specificity: 0.031
1/1 (100.0%)
1
293T cell
Specificity: 0.031
1/1 (100.0%)
1
heart
Specificity: 0.031
1/1 (100.0%)
1
HUVECs
Specificity: 0.031
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 207 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 214 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 346 | F → C | 0.002545 | SNP | Missense Mutation | GBM |