Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q86UE4 | MTDH; AEG1; LYRIC | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated … | Homo sapiens (Human) | 582 aa |
Protein Details: Q86UE4 (MTDH)
Protein Information
| Accession | Q86UE4 |
|---|---|
| Protein Names | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) |
| Gene Symbol | MTDH; AEG1; LYRIC |
| Organism | Homo sapiens (Human) |
| Length | 582 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 19801377 22496122 24357059 25914232 26111759 29575903 29733200 31251020 31382980 32651440 32944167 33636221 36430497 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.479
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
45
LNCaP cells
Specificity: 0.479
45/46 (97.8%)
13
Jurkat T cells
Specificity: 0.138
13/25 (52.0%)
10
HAP1 cells
Specificity: 0.106
10/10 (100.0%)
6
293T cells
Specificity: 0.064
6/10 (60.0%)
4
PC3 cells
Specificity: 0.043
4/4 (100.0%)
4
T cells
Specificity: 0.043
4/4 (100.0%)
3
CEMx174 cells
Specificity: 0.032
3/3 (100.0%)
2
DU145 cells
Specificity: 0.021
2/2 (100.0%)
2
Endothelial cells
Specificity: 0.021
2/2 (100.0%)
2
Cerebral cortex
Specificity: 0.021
2/4 (50.0%)
1
U937 cells
Specificity: 0.011
1/1 (100.0%)
1
HeLa cells
Specificity: 0.011
1/1 (100.0%)
1
Liver membrane
Specificity: 0.011
1/1 (100.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAARSWQDEL11AQQAEEGSAR21LREMLSVGLG31FLRTELGLDL41GLEPKRYPGW
51-10051VILVGTGALG61LLLLFLLGYG71WAAACAGARK81KRRSPPRKRE91EAAAVPAAAP
101-150101DDLALLKNLR111SEEQKKKNRK121KLSEKPKPNG131RTVEVAEGEA141VRTPQSVTAK
151-200151QPPEIDKKNE161KSKKNKKKSK171SDAKAVQNSS181RHDGKEVDEG191AWETKISHRE
201-250201KRQQRKRDKV211LTDSGSLDST221IPGIENTITV231TTEQLTTASF241PVGSKKNKGD
251-300251SHLNVQVSNF261KSGKGDSTLQ271VSSGLNENLT281VNGGGWNEKS291VKLSSQISAG
301-350301EEKWNSVSPA311SAGKRKTEPS321AWSQDTGDAN331TNGKDWGRSW341SDRSIFSGIG
351-400351STAEPVSQST361TSDYQWDVSR371NQPYIDDEWS381GLNGLSSADP391NSDWNAPAEE
401-450401WGNWVDEERA411SLLKSQEPIP421DDQKVSDDDK431EKGEGALPTG441KSKKKKKKKK
451-500451KQGEDNSTAQ461DTEELEKEIR471EDLPVNTSKT481RPKQEKAFSL491KTISTSDPAE
501-550501VLVKNSQPIK511TLPPATSTEP521SVILSKSDSD531KSSSQVPPIL541QETDKSKSNT
551-582551KQNSVPPSQT561KSETSWESPK571QIKKKKKARR581ET
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 75 | SWISSPALM Prediction (High) | Lysine-rich CEACAM1 co-isolated protein family | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 207 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 214 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 346 | F → C | 0.002545 | SNP | Missense Mutation | GBM |