Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q86VW2 | ARHGEF25 | Rho guanine nucleotide exchange factor … | Homo sapiens (Human) | 580 aa |
Protein Details: Q86VW2 (ARHGEF25)
Protein Information
| Accession | Q86VW2 |
|---|---|
| Protein Names | Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) (p63RhoGEF) |
| Gene Symbol | ARHGEF25 |
| Organism | Homo sapiens (Human) |
| Length | 580 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MRGGHKGGRC11ACPRVIRKVL21AKCGCCFARG31GRESYSIAGS41EGSISASAAS
51-10051GLAAPSGPSS61GLSSGPCSPG71PPGPVSGLRR81WLDHSKHCLS91VETEADSGQA
101-150101GPYENWMLEP111ALATGEELPE121LTLLTTLLEG131PGDKTQPPEE141ETLSQAPESE
151-200151EEQKKKALER161SMYVLSELVE171TEKMYVDDLG181QIVEGYMATM191AAQGVPESLR
201-250201GRDRIVFGNI211QQIYEWHRDY221FLQELQRCLK231DPDWLAQLFI241KHERRLHMYV
251-300251VYCQNKPKSE261HVVSEFGDSY271FEELRQQLGH281RLQLNDLLIK291PVQRIMKYQL
301-350301LLKDFLKYYN311RAGMDTADLE321QAVEVMCFVP331KRCNDMMTLG341RLRGFEGKLT
351-400351AQGKLLGQDT361FWVTEPEAGG371LLSSRGRERR381VFLFEQIIIF391SEALGGGVRG
401-450401GTQPGYVYKN411SIKVSCLGLE421GNLQGDPCRF431ALTSRGPEGG441IQRYVLQAAD
451-500451PAISQAWIKH461VAQILESQRD471FLNALQSPIE481YQRRESQTNS491LGRPRGPGVG
501-550501SPGRIQLGDQ511AQGSTHTPIN521GSLPSLLLSP531KGEVARALLP541LDKQALGDIP
551-580551QAPHDSPPVS561PTPKTPPCQA571RLAKLDEDEL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 10 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.03
|
|
| 12 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.05
|
|
| 23 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.87
|
| 25 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.92
|
| 26 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.95
|
| 67 | - | - | - |
Deep-Palm: 0.96
|
|
| 88 | - | - | - |
Deep-Palm: 0.89
|
|
| 228 | - | - | - |
Deep-Palm: 0.41
|
|
| 253 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.36
|
|
| 327 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.92
|
|
| 333 | - | - | - |
Deep-Palm: 0.85
|
|
| 416 | - | - | - |
Deep-Palm: 0.91
|
|
| 428 | - | - | - |
Deep-Palm: 0.94
|
|
| 568 | - | - | - |
Deep-Palm: 0.76
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 51 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 88 | C → G | 0.002506 | SNP | Missense Mutation | COAD |
| 244 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 253 | C → W | 0.001887 | SNP | Missense Mutation | UCEC |
| 443 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |