Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q86Y82 | STX12 | Syntaxin-12 | Homo sapiens (Human) | 276 aa |
Protein Details: Q86Y82 (STX12)
Protein Information
| Accession | Q86Y82 |
|---|---|
| Protein Names | Syntaxin-12 |
| Gene Symbol | STX12 |
| Organism | Homo sapiens (Human) |
| Length | 276 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 24357059 25914232 26111759 31251020 31382980 32651440 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSYGPLDMYR11NPGPSGPQLR21DFSSIIQTCS31GNIQRISQAT41AQIKNLMSQL
51-10051GTKQDSSKLQ61ENLQQLQHST71NQLAKETNEL81LKELGSLPLP91LSTSEQRQQR
101-150101LQKERLMNDF111SAALNNFQAV121QRRVSEKEKE131SIARARAGSR141LSAEERQREE
151-200151QLVSFDSHEE161WNQMQSQEDE171VAITEQDLEL181IKERETAIRQ191LEADILDVNQ
201-250201IFKDLAMMIH211DQGDLIDSIE221ANVESSEVHV231ERATEQLQRA241AYYQKKSRKK
251-276251MCILVLVLSV261IILILGLIIW271LVYKTK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 29 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.82
Deep-Palm: 0.86
|
|
| 252 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.238
5
Jurkat T cell
Specificity: 0.208
5/5 (100.0%)
4
LNCaP
Specificity: 0.167
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.167
4/4 (100.0%)
2
Primary T cell
Specificity: 0.083
2/2 (100.0%)
2
CEM 174 cell
Specificity: 0.083
2/2 (100.0%)
1
U937 cell
Specificity: 0.042
1/1 (100.0%)
1
EC cell
Specificity: 0.042
1/1 (100.0%)
1
heart
Specificity: 0.042
1/1 (100.0%)
1
HUVECs
Specificity: 0.042
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.125
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 97 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |