Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q8BIJ6 | Iars2 | Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) … | Mus musculus (Mouse) | 1012 aa |
Protein Details: Q8BIJ6 (Iars2)
Protein Information
| Accession | Q8BIJ6 |
|---|---|
| Protein Names | Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) |
| Gene Symbol | Iars2 |
| Organism | Mus musculus (Mouse) |
| Length | 1012 aa |
| Isoforms | No isoforms |
| Related PMIDs | 28526873 29660268 29733200 34200797 35358180 35477839 37925639 29217618 (mass) 31311849 (mass) 31772009 (mass) 34884899 (mass) 35358180 (mass) 37925639 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MHWGLCPRGP11GAAAVAAAGS21FWGPARLPSR31LGCLGMTRRL41VVRSVAGADS
51-10051PQSSSKGGRY61RDTVLLPQTS71FPMKLLGRQQ81SDMELEIQQK91CGFSELYSWQ
101-150101RERKVKTEFC111LHDGPPYANG121DPHVGHALNK131ILKDIANRFH141MMRGSKVHFV
151-200151PGWDCHGLPI161ETKVLSELGV171DAQSLSAMEI181REKARSFAQA191AIEKQKSAFV
201-250201RWGVMADWNN211CYYTFDPKYE221AKQLRVFYQM231YEKGLVYRSY241KPVYWSPSSR
251-300251TALAEAELEY261NPEHVSRSIY271VRFPLLRPPP281KLESLTDASS291PVSVLVWTTQ
301-350301PWTIPANQAI311CYMPEAKYAV321VKCSASGHLY331ILAEDKIAPV341ASALETTFDV
351-400351VAAFSGVDLE361GGTCSHPLTP371DKVSPLLPAT381HVTMAKGTGL391VHTAPAHGME
401-450401DYSVASQHSL411PMDCLVDEGG421MFTDAAGPEL431QNKAVLKEGT441DVVIKMLQAT
451-500451KNVLKEENIV461HSYPCDWRTK471TPVLIRASKQ481WFVNITDIKA491AAKESLKTVK
501-550501FIPGAALNSM511TDMLDRRPYW521CISRQRVWGV531PIPVFHHKTK541DEYLINSQTT
551-600551EHIIKLVEQH561GSDVWWTLPA571EQLLPAEVLA581QAGGPGALEY591APGQDILDIW
601-650601FDSGTSWSCV611LQDTQQRADL621YLEGKDQLGG631WFQSSLLTSV641ATRSKAPFRT
651-700651VMVHGFTLGE661KGEKMSKSLG671NVINPDTIIS681GGKDHSKEPP691YGADILRWWI
701-750701AESNVFTEVT711IGPSVLSAAR721DDISKLRNTL731RFLLGNLTGF741NPETDSVPVK
751-800751NMYVIDQYML761HLIQDFATKI771TDSYKQYDFG781KVVRLLKAFY791TRELSSFYFS
801-850801IVKDRLYCEN811EKDPKRRSCQ821TALAEILDVL831VRAFAPILPH841LAEEVFQHIP
851-900851YVTEPKSVFR861TGWINTSSIW871KKPGLEEAVE881SACAMRDSFL891GSIPGKNAAE
901-950901YEVIIVIEPG911LLFEIMEMLQ921AEETSSTSQL931NELMMASQTT941LLAQEPRERT
951-1000951AGDIELTGTF961VINLEGGDIR971EESSYKVIVV981PTAREKCPRC991WKHTSETADA
1001-10121001LCPRCAEVIG1011AK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 6 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.04
|
|
| 33 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.98
|
|
| 91 | - | - | - |
Deep-Palm: 0.44
|
|
| 110 | - | - | - |
Deep-Palm: 0.20
|
|
| 155 | tRNA synthetases class I (I L M and V) |
Brain
(34200797)
|
Brain
(35358180)
|
Deep-Palm: 0.35
|
|
| 211 | - | - | - |
Deep-Palm: 0.13
|
|
| 311 | - | - | - |
Deep-Palm: 0.11
|
|
| 323 | - | - | - |
Deep-Palm: 0.45
|
|
| 364 | - | - | - |
Deep-Palm: 0.97
|
|
| 414 | - | - | - |
Deep-Palm: 0.56
|
|
| 465 | - | - |
Brain
(35358180)
|
Deep-Palm: 0.64
|
|
| 521 | - | - |
Brain
(35358180)
|
Deep-Palm: 0.48
|
|
| 609 | - | - | - |
Deep-Palm: 0.81
|
|
| 808 | - | - | - |
Deep-Palm: 0.66
|
|
| 819 | SWISSPALM DBPTM CYSMODDB | Anticodon-binding domain of tRNA ligase |
Liver
(28526873)
|
Brain
(35358180)
|
Deep-Palm: 0.89
|
| 883 | - | - | - |
Deep-Palm: 0.97
|
|
| 987 | - | - | - |
Deep-Palm: 0.14
|
|
| 990 | - | - | - |
Deep-Palm: 0.10
|
|
| 1002 | Zinc finger found in FPG and IleRS |
Brain
(34200797)
|
Brain
(35358180)
|
Deep-Palm: 0.04
|
|
| 1005 | Zinc finger found in FPG and IleRS |
Brain
(34200797)
| - |
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.455
5
Brain
Specificity: 0.179
5/5 (100.0%)
4
Liver
Specificity: 0.143
4/4 (100.0%)
2
Testis
Specificity: 0.071
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
17
Brain tissue (Mass)
Specificity: 0.607
17/56 (30.4%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.