Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q8BRK8 | Prkaa2 | 5'-AMP-activated protein kinase catalytic subunit … | Mus musculus (Mouse) | 552 aa |
Protein Details: Q8BRK8 (Prkaa2)
Protein Information
| Accession | Q8BRK8 |
|---|---|
| Protein Names | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) |
| Gene Symbol | Prkaa2 |
| Organism | Mus musculus (Mouse) |
| Length | 552 aa |
| Isoforms | No isoforms |
| Related PMIDs | 34200797 37925639 29217618 (mass) 31311849 (mass) 31772009 (mass) 34884899 (mass) 35358180 (mass) 37925639 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAEKQKHDGR11VKIGHYVLGD21TLGVGTFGKV31KIGEHQLTGH41KVAVKILNRQ
51-10051KIRSLDVVGK61IKREIQNLKL71FRHPHIIKLY81QVISTPTDFF91MVMEYVSGGE
101-150101LFDYICKHGR111VEEVEARRLF121QQILSAVDYC131HRHMVVHRDL141KPENVLLDAQ
151-200151MNAKIADFGL161SNMMSDGEFL171RTSCGSPNYA181APEVISGRLY191AGPEVDIWSC
201-250201GVILYALLCG211TLPFDDEHVP221TLFKKIRGGV231FYIPDYLNRS241VATLLMHMLQ
251-300251VDPLKRATIK261DIREHEWFKQ271DLPSYLFPED281PSYDANVIDD291EAVKEVCEKF
301-350301ECTESEVMNS311LYSGDPQDQL321AVAYHLIIDN331RRIMNQASEF341YLASSPPSGS
351-400351FMDDSAMHIP361PGLKPHPERM371PPLIADSPKA381RCPLDALNTT391KPKSLAVKKA
401-450401KWHLGIRSQS411KACDIMAEVY421RAMKQLGFEW431KVVNAYHLRV441RRKNPVTGNY
451-500451VKMSLQLYLV461DSRSYLLDFK471SIDDEVVEQR481SGSSTPQRSC491SAAGLHRARS
501-550501SFDSSTAENH511SLSGSLTGSL521TGSTLSSASP531RLGSHTMDFF541EMCASLITAL
551-552551AR
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 106 | - | - | - |
Deep-Palm: 0.58
|
|
| 130 | - | - | - |
Deep-Palm: 0.26
|
|
| 174 | - | - |
Brain
(35358180)
|
Deep-Palm: 0.73
|
|
| 200 | - | - | - |
Deep-Palm: 0.87
|
|
| 209 | - | - | - |
Deep-Palm: 0.67
|
|
| 297 | - | - | - |
Deep-Palm: 0.08
|
|
| 302 | - | - | - |
Deep-Palm: 0.21
|
|
| 382 | - |
brain
(39008777)
| - |
Deep-Palm: 0.96
|
|
| 413 | - | - | - |
Deep-Palm: 0.86
|
|
| 490 | - |
Brain
(34200797)
| - |
Deep-Palm: 0.93
|
|
| 543 | - | - | - |
Deep-Palm: 0.05
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
2
Brain
Specificity: 0.286
2/2 (100.0%)
2
Liver
Specificity: 0.286
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Brain tissue (Mass)
Specificity: 0.429
3/56 (5.4%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.