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UniProt ID	Gene Symbol	Protein Name	Organism	Length	Action
Q8IVH8	MAP4K3	Mitogen-activated protein kinase kinase kinase …	Homo sapiens (Human)	894 aa

Protein Details: Q8IVH8 (MAP4K3)

Protein Information

Accession	Q8IVH8
Protein Names	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)
Gene Symbol	MAP4K3
Organism	Homo sapiens (Human)
Length	894 aa
Isoforms	No isoforms
Related PMIDs	No related PMIDs
Database Sources	CysModDB dbPTM SwissPalm

These studies detected palmitoylation of this protein in the samples.

Protein Sequence

Types:
Experimental Database High Prediction Non-palmitylated Cys

1-501MNPGFDLSRR11NPQEDFELIQ21RIGSGTYGDV31YKARNVNTGE41LAAIKVIKLE

51-10051PGEDFAVVQQ61EIIMMKDCKH71PNIVAYFGSY81LRRDKLWICM91EFCGGGSLQD

101-150101IYHVTGPLSE111LQIAYVSRET121LQGLYYLHSK131GKMHRDIKGA141NILLTDNGHV

151-200151KLADFGVSAQ161ITATIAKRKS171FIGTPYWMAP181EVAAVERKGG191YNQLCDLWAV

201-250201GITAIELAEL211QPPMFDLHPM221RALFLMTKSN231FQPPKLKDKM241KWSNSFHHFV

251-300251KMALTKNPKK261RPTAEKLLQH271PFVTQHLTRS281LAIELLDKVN291NPDHSTYHDF

301-350301DDDDPEPLVA311VPHRIHSTSR321NVREEKTRSE331ITFGQVKFDP341PLRKETEPHH

351-400351ELPDSDGFLD361SSEEIYYTAR371SNLDLQLEYG381QGHQGGYFLG391ANKSLLKSVE

401-450401EELHQRGHVA411HLEDDEGDDD421ESKHSTLKAK431IPPPLPPKPK441SIFIPQEMHS

451-500451TEDENQGTIK461RCPMSGSPAK471PSQVPPRPPP481PRLPPHKPVA491LGNGMSSFQL

501-550501NGERDGSLCQ511QQNEHRGTNL521SRKEKKDVPK531PISNGLPPTP541KVHMGACFSK

551-600551VFNGCPLKIH561CASSWINPDT571RDQYLIFGAE581EGIYTLNLNE591LHETSMEQLF

601-650601PRRCTWLYVM611NNCLLSISGK621ASQLYSHNLP631GLFDYARQMQ641KLPVAIPAHK

651-700651LPDRILPRKF661SVSAKIPETK671WCQKCCVVRN681PYTGHKYLCG691ALQTSIVLLE

701-750701WVEPMQKFML711IKHIDFPIPC721PLRMFEMLVV731PEQEYPLVCV741GVSRGRDFNQ

751-800751VVRFETVNPN761STSSWFTESD771TPQTNVTHVT781QLERDTILVC791LDCCIKIVNL

801-850801QGRLKSSRKL811SSELTFDFQI821ESIVCLQDSV831LAFWKHGMQG841RSFRSNEVTQ

851-894851EISDSTRIFR861LLGSDRVVVL871ESRPTDNPTA881NSNLYILAGH891ENSY

Palmitoylation Sites Details

Position	Database	Domains	Literature (PMID/Cell-Tissue)	Mass(PMID/Cell-Tissue)	Prediction Scores
68		-	-	-	Deep-Palm: 0.05
89		-	-	-	GPS-Palm: 0.72 Deep-Palm: 0.15
93		-	-	-	GPS-Palm: 0.77 Deep-Palm: 0.30
195		-	-	-	Deep-Palm: 0.89
462		-	-	-	GPS-Palm: 0.67 Deep-Palm: 0.11
509		-	-	-	Deep-Palm: 0.53
547		-	-	-	Deep-Palm: 0.34
555		-	-	-	GPS-Palm: 0.76 Deep-Palm: 0.08
561		-	-	-	Deep-Palm: 0.12
604	SWISSPALM DBPTM CYSMODDB	CNH domain	-	-	Deep-Palm: 0.26
613	SWISSPALM DBPTM CYSMODDB	CNH domain	-	-	Deep-Palm: 0.63
672		-	-	-	GPS-Palm: 0.83 Deep-Palm: 0.12
675		-	-	-	GPS-Palm: 0.70 Deep-Palm: 0.10
676		-	-	-	GPS-Palm: 0.84 Deep-Palm: 0.14
689		-	-	-	GPS-Palm: 0.70 Deep-Palm: 0.51
720		-	-	-	GPS-Palm: 0.82 Deep-Palm: 0.28
739		-	-	-	Deep-Palm: 0.83
790		-	-	-	GPS-Palm: 0.88 Deep-Palm: 0.60
793		-	-	-	GPS-Palm: 0.90 Deep-Palm: 0.74
794		-	-	-	GPS-Palm: 0.88 Deep-Palm: 0.79
825		-	-	-	Deep-Palm: 0.16

Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)

Conservation score for cysteine

PhyloP for Cysteine

PhastCons Conservation Scores for Cysteine

TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position	Amino Acid Change	Frequency	Type	Function	Cancer Type
27	Y → C	0.002506	SNP	Missense Mutation	COAD
76	Y → C	0.002506	SNP	Missense Mutation	COAD
125	Y → C	0.002294	SNP	Missense Mutation	OV
155	F → C	0.001887	SNP	Missense Mutation	UCEC
191	Y → C	0.005435	SNP	Missense Mutation	ESCA
228	K → Cfs*16	0.001887	INS	Frame Shift Ins	UCEC
328	R → C	0.001887	SNP	Missense Mutation	UCEC
577	F → C	0.001887	SNP	Missense Mutation	UCEC
793	C → C	0.002294	SNP	Splice Region	OV