Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q8IYC8 BACE1 Beta-secretase 1 (EC 3.4.23.46) (Beta-site … Homo sapiens (Human) 501 aa

Protein Details: Q8IYC8 (BACE1)

Protein Information
AccessionQ8IYC8
Protein NamesBeta-secretase 1 (EC 3.4.23.46) (Beta-site amyloid precursor protein cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)
Gene SymbolBACE1
OrganismHomo sapiens (Human)
Length501 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAQALPWLLL11WMGAGVLPAH21GTQHGIRLPL31RSGLGGAPLG41LRLPRETDEE
51-10051PEEPGRRGSF61VEMVDNLRGK71SGQGYYVEMT81VGSPPQTLNI91LVDTGSSNFA
101-150101VGAAPHPFLH111RYYQRQLFST121YRDLRKGVYV131PYTQGKWEGE141LGTDLVSIPH
151-200151GPNVTVRANI161AAITESDKFF171INGSNWEGIL181GLAYAEIARP191DDSLEPFFDS
201-250201LVKQTHVPNL211FSLQLCGAGF221PLNQSEVLAS231VGGSMIIGGI241DHSLYTGSLW
251-300251YTPIRREWYY261EVIIVRVEIN271GQDLKMDCKE281YNYDKSIVDS291GTTNLRLPKK
301-350301VFEAAVKSIK311AASSTEKFPD321GFWLGEQLVC331WQAGTTPWNI341FPVISLYLMG
351-400351EVTNQSFRIT361ILPQQYLRPV371EDVATSQDDC381YKFAISQSST391GTVMGAVIME
401-450401GFYVVFDRAR411KRIGFAVSAC421HVHDEFRTAA431VEGPFVTLDM441EDCGYNIPQT
451-500451DESTLMTIAY461VMAAICALFM471LPLCLMVCQW481RCLRCLRQQH491DDFADDISLL
501-501501K
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
216 - - -
Deep-Palm: 0.91
278 - - -
Deep-Palm: 0.07
330 - - -
Deep-Palm: 0.33
380 - - -
Deep-Palm: 0.60
420 - - -
GPS-Palm: 0.84
Deep-Palm: 0.87
443 - - -
Deep-Palm: 0.17
466 - - -
Deep-Palm: 0.09
474 DBPTM SWISSPALM - - -
GPS-Palm: 0.90
Deep-Palm: 0.50
478 DBPTM SWISSPALM - - -
GPS-Palm: 0.97
Deep-Palm: 0.78
482 DBPTM SWISSPALM - - -
GPS-Palm: 0.93
Deep-Palm: 0.63
485 DBPTM SWISSPALM - - -
GPS-Palm: 0.89
Deep-Palm: 0.58
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
239 G → C 0.001887 SNP Missense Mutation UCEC
296 R → C 0.001764 SNP Missense Mutation LUAD
330 C → W 0.002545 SNP Missense Mutation GBM
487 R → C 0.002506 SNP Missense Mutation COAD
487 R → C 0.007299 SNP Missense Mutation READ