Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q8IZH2 | XRN1 | 5'-3' exoribonuclease 1 (EC 3.1.13.-) … | Homo sapiens (Human) | 1706 aa |
Protein Details: Q8IZH2 (XRN1)
Protein Information
| Accession | Q8IZH2 |
|---|---|
| Protein Names | 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog) |
| Gene Symbol | XRN1 |
| Organism | Homo sapiens (Human) |
| Length | 1706 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGVPKFYRWI11SERYPCLSEV21VKEHQIPEFD31NLYLDMNGII41HQCSHPNDDD
51-10051VHFRISDDKI61FTDIFHYLEV71LFRIIKPRKV81FFMAVDGVAP91RAKMNQQRGR
101-150101RFRSAKEAED111KIKKAIEKGE121TLPTEARFDS131NCITPGTEFM141ARLHEHLKYF
151-200151VNMKISTDKS161WQGVTIYFSG171HETPGEGEHK181IMEFIRSEKA191KPDHDPNTRH
201-250201CLYGLDADLI211MLGLTSHEAH221FSLLREEVRF231GGKKTQRVCA241PEETTFHLLH
251-300251LSLMREYIDY261EFSVLKEKIT271FKYDIERIID281DWILMGFLVG291NDFIPHLPHL
301-350301HINHDALPLL311YGTYVTILPE321LGGYINESGH331LNLPRFEKYL341VKLSDFDREH
351-400351FSEVFVDLKW361FESKVGNKYL371NEAAGVAAEE381ARNYKEKKKL391KGQENSLCWT
401-450401ALDKNEGEMI411TSKDNLEDET421EDDDLFETEF431RQYKRTYYMT441KMGVDVVSDD
451-500451FLADQAACYV461QAIQWILHYY471YHGVQSWSWY481YPYHYAPFLS491DIHNISTLKI
501-550501HFELGKPFKP511FEQLLAVLPA521ASKNLLPACY531QHLMTNEDSP541IIEYYPPDFK
551-600551TDLNGKQQEW561EAVVLIPFID571EKRLLEAMET581CNHSLKKEER591KRNQHSECLM
601-650601CWYDRDTEFI611YPSPWPEKFP621AIERCCTRYK631IISLDAWRVD641INKNKITRID
651-700651QKALYFCGFP661TLKHIRHKFF671LKKSGVQVFQ681QSSRGENMML691EILVDAESDE
701-750701LTVENVASSV711LGKSVFVNWP721HLEEARVVAV731SDGETKFYLE741EPPGTQKLYS
751-800751GRTAPPSKVV761HLGDKEQSNW771AKEVQGISEH781YLRRKGIIIN791ETSAVVYAQL
801-850801LTGRKYQINQ811NGEVRLEKQW821SKQVVPFVYQ831TIVKDIRAFD841SRFSNIKTLD
851-900851DLFPLRSMVF861MLGTPYYGCT871GEVQDSGDVI881TEGRIRVIFS891IPCEPNLDAL
901-950901IQNQHKYSIK911YNPGYVLASR921LGVSGYLVSR931FTGSIFIGRG941SRRNPHGDHK
951-1000951ANVGLNLKFN961KKNEEVPGYT971KKVGSEWMYS981SAAEQLLAEY991LERAPELFSY
1001-10501001IAKNSQEDVF1011YEDDIWPGEN1021ENGAEKVQEI1031ITWLKGHPVS1041TLSRSSCDLQ
1051-11001051ILDAAIVEKI1061EEEVEKCKQR1071KNNKKVRVTV1081KPHLLYRPLE1091QQHGVIPDRD
1101-11501101AEFCLFDRVV1111NVRENFSVPV1121GLRGTIIGIK1131GANREADVLF1141EVLFDEEFPG
1151-12001151GLTIRCSPGR1161GYRLPTSALV1171NLSHGSRSET1181GNQKLTAIVK1191PQPAVHQHSS
1201-12501201SSSVSSGHLG1211ALNHSPQSLF1221VPTQVPTKDD1231DEFCNIWQSL1241QGSGKMQYFQ
1251-13001251PTIQEKGAVL1261PQEISQVNQH1271HKSGFNDNSV1281KYQQRKHDPH1291RKFKEECKSP
1301-13501301KAECWSQKMS1311NKQPNSGIEN1321FLASLNISKE1331NEVQSSHHGE1341PPSEEHLSPQ
1351-14001351SFAMGTRMLK1361EILKIDGSNT1371VDHKNEIKQI1381ANEIPVSSNR1391RDEYGLPSQP
1401-14501401KQNKKLASYM1411NKPHSANEYH1421NVQSMDNMCW1431PAPSQIPPVS1441TPVTELSRIC
1451-15001451SLVGMPQPDF1461SFLRMPQTMT1471VCQVKLSNGL1481LVHGPQCHSE1491NEAKEKAALF
1501-15501501ALQQLGSLGM1511NFPLPSQVFA1521NYPSAVPPGT1531IPPAFPPPTG1541WDHYGSNYAL
1551-16001551GAANIMPSSS1561HLFGSMPWGP1571SVPVPGKPFH1581HTLYSGTMPM1591AGGIPGGVHN
1601-16501601QFIPLQVTKK1611RVANKKNFEN1621KEAQSSQATP1631VQTSQPDSSN1641IVKVSPRESS
1651-17001651SASLKSSPIA1661QPASSFQVET1671ASQGHSISHH1681KSTPISSSRR1691KSRKLAVNFG
1701-17061701VSKPSE
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 16 | Xrn1, N-terminal 5'-3' exoribonuclease | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.63
|
|
| 43 | Xrn1, N-terminal 5'-3' exoribonuclease | - | - |
Deep-Palm: 0.02
|
|
| 132 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.77
Deep-Palm: 0.91
|
|
| 201 | - | - | - |
Deep-Palm: 0.59
|
|
| 239 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.90
|
|
| 398 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.93
|
|
| 458 | - | - | - |
Deep-Palm: 0.08
|
|
| 529 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.96
|
|
| 581 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.94
|
|
| 598 | - | - | - |
Deep-Palm: 0.19
|
|
| 601 | - | - | - |
Deep-Palm: 0.12
|
|
| 625 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.55
|
|
| 626 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.58
|
|
| 657 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.56
|
|
| 869 | - | - | - |
Deep-Palm: 0.35
|
|
| 893 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.77
|
|
| 1047 | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.95
|
|
| 1067 | - | - | - |
Deep-Palm: 0.93
|
|
| 1104 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.38
|
|
| 1156 | - | - | - |
Deep-Palm: 0.97
|
|
| 1234 | - | - | - |
Deep-Palm: 0.11
|
|
| 1297 | - | - | - |
Deep-Palm: 0.09
|
|
| 1304 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.18
|
|
| 1429 | - | - | - |
Deep-Palm: 0.03
|
|
| 1450 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.87
|
|
| 1472 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.70
|
|
| 1487 | - | - | - |
Deep-Palm: 0.65
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 65 | F → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 73 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 73 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 73 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 73 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 132 | C → Y | 0.002020 | SNP | Missense Mutation | PRAD |
| 239 | C → Lfs*14 | 0.003559 | DEL | Frame Shift Del | KIRP |
| 257 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 459 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |
| 602 | W → Cfs*21 | 0.001764 | DEL | Frame Shift Del | LUAD |
| 684 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 804 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 815 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 815 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 815 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 827 | F → C | 0.002288 | SNP | Missense Mutation | STAD |
| 842 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 842 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 890 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 950 | K → delinsTAMTQNLLCEHR*E | 0.001887 | INS | Nonsense Mutation | UCEC |
| 1104 | C → Vfs*7 | 0.001887 | DEL | Frame Shift Del | UCEC |
| 1275 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1309 | M → Cfs*14 | 0.002506 | DEL | Frame Shift Del | COAD |
| 1394 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1506 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1541 | W → C | 0.002033 | SNP | Missense Mutation | LUSC |