Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q8IZT6 ASPM Abnormal spindle-like microcephaly-associated protein (Abnormal … Homo sapiens (Human) 3477 aa

Protein Details: Q8IZT6 (ASPM)

Protein Information
AccessionQ8IZT6
Protein NamesAbnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog)
Gene SymbolASPM
OrganismHomo sapiens (Human)
Length3477 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MANRRVGRGC11WEVSPTERRP21PAGLRGPAAE31EEASSPPVLS41LSHFCRSPFL
51-10051CFGDVLLGAS61RTLSLALDNP71NEEVAEVKIS81HFPAADLGFS91VSQRCFVLQP
101-150101KEKIVISVNW111TPLKEGRVRE121IMTFLVNDVL131KHQAILLGNA141EEQKKKKRSL
151-200151WDTIKKKKIS161ASTSHNRRVS171NIQNVNKTFS181VSQKVDRVRS191PLQACENLAM
201-250201NEGGPPTENN211SLILEENKIP221ISPISPAFNE231CHGATCLPLS241VRRSTTYSSL
251-300251HASENRELLN261VHSANVSKVS271FNEKAVTETS281FNSVNVNGQR291GENSKLSLTP
301-350301NCSSTLNITQ311SQIHFLSPDS321FVNNSHGANN331ELELVTCLSS341DMFMKDNSQP
351-400351VHLESTIAHE361IYQKILSPDS371FIKDNYGLNQ381DLESESVNPI391LSPNQFLKDN
401-450401MAYMCTSQQT411CKVPLSNENS421QVPQSPEDWR431KSEVSPRIPE441CQGSKSPKAI
451-500451FEELVEMKSN461YYSFIKQNNP471KFSAVQDISS481HSHNKQPKRR491PILSATVTKR
501-550501KATCTRENQT511EINKPKAKRC521LNSAVGEHEK531VINNQKEKED541FHSYLPIIDP
551-600551ILSKSKSYKN561EVTPSSTTAS571VARKRKSDGS581MEDANVRVAI591TEHTEVREIK
601-650601RIHFSPSEPK611TSAVKKTKNV621TTPISKRISN631REKLNLKKKT641DLSIFRTPIS
651-700651KTNKRTKPII661AVAQSSLTFI671KPLKTDIPRH681PMPFAAKNMF691YDERWKEKQE
701-750701QGFTWWLNFI711LTPDDFTVKT721NISEVNAATL731LLGIENQHKI741SVPRAPTKEE
751-800751MSLRAYTARC761RLNRLRRAAC771RLFTSEKMVK781AIKKLEIEIE791ARRLIVRKDR
801-850801HLWKDVGERQ811KVLNWLLSYN821PLWLRIGLET831TYGELISLED841NSDVTGLAMF
851-900851ILNRLLWNPD861IAAEYRHPTV871PHLYRDGHEE881ALSKFTLKKL891LLLVCFLDYA
901-950901KISRLIDHDP911CLFCKDAEFK921ASKEILLAFS931RDFLSGEGDL941SRHLGLLGLP
951-1000951VNHVQTPFDE961FDFAVTNLAV971DLQCGVRLVR981TMELLTQNWD991LSKKLRIPAI
1001-10501001SRLQKMHNVD1011IVLQVLKSRG1021IELSDEHGNT1031ILSKDIVDRH1041REKTLRLLWK
1051-11001051IAFAFQVDIS1061LNLDQLKEEI1071AFLKHTKSIK1081KTISLLSCHS1091DDLINKKKGK
1101-11501101RDSGSFEQYS1111ENIKLLMDWV1121NAVCAFYNKK1131VENFTVSFSD1141GRVLCYLIHH
1151-12001151YHPCYVPFDA1161ICQRTTQTVE1171CTQTGSVVLN1181SSSESDDSSL1191DMSLKAFDHE
1201-12501201NTSELYKELL1211ENEKKNFHLV1221RSAVRDLGGI1231PAMINHSDMS1241NTIPDEKVVI
1251-13001251TYLSFLCARL1261LDLRKEIRAA1271RLIQTTWRKY1281KLKTDLKRHQ1291EREKAARIIQ
1301-13501301LAVINFLAKQ1311RLRKRVNAAL1321VIQKYWRRVL1331AQRKLLMLKK1341EKLEKVQNKA
1351-14001351ASLIQGYWRR1361YSTRQRFLKL1371KYYSIILQSR1381IRMIIAVTSY1391KRYLWATVTI
1401-14501401QRHWRAYLRR1411KQDQQRYEML1421KSSTLIIQSM1431FRKWKQRKMQ1441SQVKATVILQ
1451-15001451RAFREWHLRK1461QAKEENSAII1471IQSWYRMHKE1481LRKYIYIRSC1491VVIIQKRFRC
1501-15501501FQAQKLYKRR1511KESILTIQKY1521YKAYLKGKIE1531RTNYLQKRAA1541AIQLQAAFRR
1551-16001551LKAHNLCRQI1561RAACVIQSYW1571RMRQDRVRFL1581NLKKTIIKFQ1591AHVRKHQQRQ
1601-16501601KYKKMKKAAV1611IIQTHFRAYI1621FAMKVLASYQ1631KTRSAVIVLQ1641SAYRGMQARK
1651-17001651MYIHILTSVI1661KIQSYYRAYV1671SKKEFLSLKN1681ATIKLQSTVK1691MKQTRKQYLH
1701-17501701LRAAALFIQQ1711CYRSKKIAAQ1721KREEYMQMRE1731SCIKLQAFVR1741GYLVRKQMRL
1751-18001751QRKAVISLQS1761YFRMRKARQY1771YLKMYKAIIV1781IQNYYHAYKA1791QVNQRKNFLQ
1801-18501801VKKAATCLQA1811AYRGYKVRQL1821IKQQSIAALK1831IQSAFRGYNK1841RVKYQSVLQS
1851-19001851IIKIQRWYRA1861YKTLHDTRTH1871FLKTKAAVIS1881LQSAYRGWKV1891RKQIRREHQA
1901-19501901ALKIQSAFRM1911AKAQKQFRLF1921KTAALVIQQN1931FRAWTAGRKQ1941CMEYIELRHA
1951-20001951VLVLQSMWKG1961KTLRRQLQRQ1971HKCAIIIQSY1981YRMHVQQKKW1991KIMKKAALLI
2001-20502001QKYYRAYSIG2011REQNHLYLKT2021KAAVVTLQSA2031YRGMKVRKRI2041KDCNKAAVTI
2051-21002051QSKYRAYKTK2061KKYATYRASA2071IIIQRWYRGI2081KITNHQHKEY2091LNLKKTAIKI
2101-21502101QSVYRGIRVR2111RHIQHMHRAA2121TFIKAMFKMH2131QSRISYHTMR2141KAAIVIQVRC
2151-22002151RAYYQGKMQR2161EKYLTILKAV2171KVLQASFRGV2181RVRRTLRKMQ2191TAATLIQSNY
2201-22502201RRYRQQTYFN2211KLKKITKTVQ2221QRYWAMKERN2231IQFQRYNKLR2241HSVIYIQAIF
2251-23002251RGKKARRHLK2261MMHIAATLIQ2271RRFRTLMMRR2281RFLSLKKTAI2291LIQRKYRAHL
2301-23502301CTKHHLQFLQ2311VQNAVIKIQS2321SYRRWMIRKR2331MREMHRAATF2341IQSTFRMHRL
2351-24002351HMRYQALKQA2361SVVIQQQYQA2371NRAAKLQRQH2381YLRQRHSAVI2391LQAAFRGMKT
2401-24502401RRHLKSMHSS2411ATLIQSRFRS2421LLVRRRFISL2431KKATIFVQRK2441YRATICAKHK
2451-25002451LYQFLHLRKA2461AITIQSSYRR2471LMVKKKLQEM2481QRAAVLIQAT2491FRMYRTYITF
2501-25502501QTWKHASILI2511QQHYRTYRAA2521KLQRENYIRQ2531WHSAVVIQAA2541YKGMKARQLL
2551-26002551REKHKASIVI2561QSTYRMYRQY2571CFYQKLQWAT2581KIIQEKYRAN2591KKKQKVFQHN
2601-26502601ELKKETCVQA2611GFQDMNIKKQ2621IQEQHQAAII2631IQKHCKAFKI2641RKHYLHLRAT
2651-27002651VVSIQRRYRK2661LTAVRTQAVI2671CIQSYYRGFK2681VRKDIQNMHR2691AATLIQSFYR
2701-27502701MHRAKVDYET2711KKTAIVVIQN2721YYRLYVRVKT2731ERKNFLAVQK2741SVRTIQAAFR
2751-28002751GMKVRQKLKN2761VSEEKMAAIV2771NQSALCCYRS2781KTQYEAVQSE2791GVMIQEWYKA
2801-28502801SGLACSQEAE2811YHSQSRAAVT2821IQKAFCRMVT2831RKLETQKCAA2841LRIQFFLQMA
2851-29002851VYRRRFVQQK2861RAAITLQHYF2871RTWQTRKQFL2881LYRKAAVVLQ2891NHYRAFLSAK
2901-29502901HQRQVYLQIR2911SSVIIIQARS2921KGFIQKRKFQ2931EIKNSTIKIQ2941AMWRRYRAKK
2951-30002951YLCKVKAACK2961IQAWYRCWRA2971HKEYLAILKA2981VKIIQGCFYT2991KLERTRFLNV
3001-30503001RASAIIIQRK3011WRAILPAKIA3021HEHFLMIKRH3031RAACLIQAHY3041RGYKGRQVFL
3051-31003051RQKSAALIIQ3061KYIRAREAGK3071HERIKYIEFK3081KSTVILQALV3091RGWLVRKRFL
3101-31503101EQRAKIRLLH3111FTAAAYYHLN3121AVRIQRAYKL3131YLAVKNANKQ3141VNSVICIQRW
3151-32003151FRARLQEKRF3161IQKYHSIKKI3171EHEGQECLSQ3181RNRAASVIQK3191AVRHFLLRKK
3201-32503201QEKFTSGIIK3211IQALWRGYSW3221RKKNDCTKIK3231AIRLSLQVVN3241REIREENKLY
3251-33003251KRTALALHYL3261LTYKHLSAIL3271EALKHLEVVT3281RLSPLCCENM3291AQSGAISKIF
3301-33503301VLIRSCNRSI3311PCMEVIRYAV3321QVLLNVSKYE3331KTTSAVYDVE3341NCIDILLELL
3351-34003351QIYREKPGNK3361VADKGGSIFT3371KTCCLLAILL3381KTTNRASDVR3391SRSKVVDRIY
3401-34503401SLYKLTAHKH3411KMNTERILYK3421QKKNSSISIP3431FIPETPVRTR3441IVSRLKPDWV
3451-34773451LRRDNMEEIT3461NPLQAIQMVM3471DTLGIPY
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
10 - - -
GPS-Palm: 0.82
Deep-Palm: 0.12
45 Abnormal spindle-like microcephaly-associated protein, ASH domain - -
Deep-Palm: 0.96
51 - - -
GPS-Palm: 0.76
Deep-Palm: 0.97
95 - - -
GPS-Palm: 0.76
Deep-Palm: 0.56
195 - - -
GPS-Palm: 0.85
Deep-Palm: 0.79
231 - - -
GPS-Palm: 0.67
Deep-Palm: 0.72
236 - - -
Deep-Palm: 0.74
302 - - -
GPS-Palm: 0.71
Deep-Palm: 0.79
337 - - -
Deep-Palm: 0.13
405 - - -
GPS-Palm: 0.69
Deep-Palm: 0.07
411 - - -
Deep-Palm: 0.04
441 - - -
GPS-Palm: 0.80
Deep-Palm: 0.91
504 - - -
GPS-Palm: 0.77
Deep-Palm: 0.80
520 - - -
Deep-Palm: 0.69
760 - - -
GPS-Palm: 0.87
Deep-Palm: 0.96
770 - - -
GPS-Palm: 0.90
Deep-Palm: 0.94
895 - - -
GPS-Palm: 0.94
Deep-Palm: 0.97
911 - - -
Deep-Palm: 0.87
914 - - -
Deep-Palm: 0.87
974 - - -
GPS-Palm: 0.89
Deep-Palm: 0.88
1088 - - -
GPS-Palm: 0.91
Deep-Palm: 0.92
1124 - - -
GPS-Palm: 0.90
Deep-Palm: 0.36
1145 - - -
Deep-Palm: 0.13
1154 - - -
Deep-Palm: 0.07
1162 - - -
Deep-Palm: 0.02
1171 - - -
GPS-Palm: 0.65
Deep-Palm: 0.43
1257 - - -
GPS-Palm: 0.95
Deep-Palm: 0.98
1490 - - -
GPS-Palm: 0.95
Deep-Palm: 0.33
1500 - - -
GPS-Palm: 0.95
Deep-Palm: 0.34
1557 - - -
GPS-Palm: 0.80
Deep-Palm: 0.25
1564 - - -
GPS-Palm: 0.90
Deep-Palm: 0.25
1711 - - -
GPS-Palm: 0.97
Deep-Palm: 0.74
1732 - - -
GPS-Palm: 0.85
Deep-Palm: 0.79
1807 - - -
GPS-Palm: 0.93
Deep-Palm: 0.76
1941 - - -
GPS-Palm: 0.74
Deep-Palm: 0.36
1973 - - -
GPS-Palm: 0.80
Deep-Palm: 0.06
2043 - - -
GPS-Palm: 0.89
Deep-Palm: 0.69
2150 - - -
GPS-Palm: 0.86
Deep-Palm: 0.19
2301 - - -
Deep-Palm: 0.29
2446 - - -
GPS-Palm: 0.80
Deep-Palm: 0.79
2571 - - -
GPS-Palm: 0.85
Deep-Palm: 0.13
2607 - - -
Deep-Palm: 0.39
2635 - - -
GPS-Palm: 0.70
Deep-Palm: 0.12
2671 - - -
GPS-Palm: 0.91
Deep-Palm: 0.62
2776 -
HeLa (37611173)
-
GPS-Palm: 0.92
Deep-Palm: 0.62
2777 -
HeLa (37611173)
-
GPS-Palm: 0.94
Deep-Palm: 0.56
2805 - - -
Deep-Palm: 0.75
2826 - - -
GPS-Palm: 0.94
Deep-Palm: 0.60
2838 - - -
GPS-Palm: 0.76
Deep-Palm: 0.56
2953 - - -
GPS-Palm: 0.91
Deep-Palm: 0.28
2959 - - -
GPS-Palm: 0.89
Deep-Palm: 0.32
2967 - - -
Deep-Palm: 0.50
2987 - - -
GPS-Palm: 0.95
Deep-Palm: 0.89
3034 - - -
GPS-Palm: 0.90
Deep-Palm: 0.48
3146 - - -
GPS-Palm: 0.90
Deep-Palm: 0.40
3177 - - -
GPS-Palm: 0.69
Deep-Palm: 0.74
3226 - - -
GPS-Palm: 0.83
Deep-Palm: 0.66
3286 - - -
GPS-Palm: 0.67
Deep-Palm: 0.93
3287 - - -
GPS-Palm: 0.82
Deep-Palm: 0.93
3306 - - -
GPS-Palm: 0.91
Deep-Palm: 0.68
3312 - - -
GPS-Palm: 0.83
Deep-Palm: 0.57
3342 - - -
Deep-Palm: 0.82
3373 - - -
GPS-Palm: 0.94
Deep-Palm: 0.94
3374 - - -
GPS-Palm: 0.94
Deep-Palm: 0.94
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
45 C → Y 0.002288 SNP Missense Mutation STAD
162 S → C 0.002427 SNP Missense Mutation BLCA
236 C → F 0.002033 SNP Missense Mutation LUSC
370 S → C 0.002033 SNP Missense Mutation LUSC
472 F → C 0.001887 SNP Missense Mutation UCEC
490 R → C 0.001887 SNP Missense Mutation UCEC
557 S → C 0.002288 SNP Missense Mutation STAD
766 R → C 0.001887 SNP Missense Mutation UCEC
809 R → C 0.001887 SNP Missense Mutation UCEC
819 Y → C 0.001764 SNP Missense Mutation LUAD
854 R → C 0.017544 SNP Missense Mutation UCS
877 G → C 0.002033 SNP Missense Mutation LUSC
942 R → C 0.002141 SNP Missense Mutation SKCM
942 R → C 0.012195 SNP Missense Mutation MESO
974 C → G 0.005435 SNP Missense Mutation ESCA
977 R → C 0.002288 SNP Missense Mutation STAD
977 R → C 0.002506 SNP Missense Mutation COAD
1132 E → Cfs*32 0.001014 INS Frame Shift Ins BRCA
1132 E → Cfs*32 0.001887 INS Frame Shift Ins UCEC
1171 C → C 0.002506 SNP Silent COAD
1390 Y → C 0.001887 SNP Missense Mutation UCEC
1437 R → C 0.002506 SNP Missense Mutation COAD
1486 Y → C 0.001764 SNP Missense Mutation LUAD
1498 F → C 0.001887 SNP Missense Mutation UCEC
1500 C → Lfs*9 0.002033 INS Frame Shift Ins LUSC
1622 A → Cfs*23 0.001887 INS Frame Shift Ins UCEC
1633 R → C 0.001887 SNP Missense Mutation UCEC
1707 F → C 0.001887 SNP Missense Mutation UCEC
1713 R → C 0.002141 SNP Missense Mutation SKCM
1941 C → Y 0.001887 SNP Missense Mutation UCEC
1948 R → C 0.002141 SNP Missense Mutation SKCM
2079 G → C 0.001887 SNP Missense Mutation UCEC
2122 F → delinsCFCYFL*L 0.002506 INS Nonsense Mutation COAD
2163 Y → C 0.002288 SNP Missense Mutation STAD
2437 V → Cfs*14 0.002288 INS Frame Shift Ins STAD
2533 S → C 0.002288 SNP Missense Mutation STAD
2564 Y → C 0.001764 SNP Missense Mutation LUAD
2665 R → C 0.001887 SNP Missense Mutation UCEC
2811 Y → C 0.002288 SNP Missense Mutation STAD
2959 C → F 0.001764 SNP Missense Mutation LUAD
2964 W → C 0.001764 SNP Missense Mutation LUAD
2965 Y → C 0.001764 SNP Missense Mutation LUAD
3099 F → C 0.001887 SNP Missense Mutation UCEC
3193 R → C 0.002288 SNP Missense Mutation STAD
3193 R → C 0.001887 SNP Missense Mutation UCEC
3198 R → C 0.010870 SNP Missense Mutation ACC
3198 R → C 0.002141 SNP Missense Mutation SKCM
3220 W → C 0.001764 SNP Missense Mutation LUAD
3287 C → Y 0.002288 SNP Missense Mutation STAD
3308 R → C 0.001887 SNP Missense Mutation UCEC
3312 C → F 0.002033 SNP Missense Mutation LUSC
3431 F → C 0.001887 SNP Missense Mutation UCEC