Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q8N3E9 | PLCD3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC … | Homo sapiens (Human) | 789 aa |
Protein Details: Q8N3E9 (PLCD3)
Protein Information
| Accession | Q8N3E9 |
|---|---|
| Protein Names | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) |
| Gene Symbol | PLCD3 |
| Organism | Homo sapiens (Human) |
| Length | 789 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MLCGRWRRCR11RPPEEPPVAA21QVAAQVAAPV31ALPSPPTPSD41GGTKRPGLRA
51-10051LKKMGLTEDE61DVRAMLRGSR71LRKIRSRTWH81KERLYRLQED91GLSVWFQRRI
101-150101PRAPSQHIFF111VQHIEAVREG121HQSEGLRRFG131GAFAPARCLT141IAFKGRRKNL
151-200151DLAAPTAEEA161QRWVRGLTKL171RARLDAMSQR181ERLDHWIHSY191LHRADSNQDS
201-250201KMSFKEIKSL211LRMVNVDMND221MYAYLLFKEC231DHSNNDRLEG241AEIEEFLRRL
251-300251LKRPELEEIF261HQYSGEDRVL271SAPELLEFLE281DQGEEGATLA291RAQQLIQTYE
301-350301LNETAKQHEL311MTLDGFMMYL321LSPEGAALDN331THTCVFQDMN341QPLAHYFISS
351-400351SHNTYLTDSQ361IGGPSSTEAY371VRAFAQGCRC381VELDCWEGPG391GEPVIYHGHT
401-450401LTSKILFRDV411VQAVRDHAFT421LSPYPVILSL431ENHCGLEQQA441AMARHLCTIL
451-500451GDMLVTQALD461SPNPEELPSP471EQLKGRVLVK481GKKLPAARSE491DGRALSDREE
501-550501EEEDDEEEEE511EVEAAAQRRL521AKQISPELSA531LAVYCHATRL541RTLHPAPNAP
551-600551QPCQVSSLSE561RKAKKLIREA571GNSFVRHNAR581QLTRVYPLGL591RMNSANYSPQ
601-650601EMWNSGCQLV611ALNFQTPGYE621MDLNAGRFLV631NGQCGYVLKP641ACLRQPDSTF
651-700651DPEYPGPPRT661TLSIQVLTAQ671QLPKLNAEKP681HSIVDPLVRI691EIHGVPADCA
701-750701RQETDYVLNN711GFNPRWGQTL721QFQLRAPELA731LVRFVVEDYD741ATSPNDFVGQ
751-789751FTLPLSSLKQ761GYRHIHLLSK771DGASLSPATL781FIQIRIQRS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 3 | - | - | - |
GPS-Palm: 0.98
Deep-Palm: 0.02
|
|
| 9 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.05
|
|
| 138 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.98
|
|
| 230 | - | - | - |
Deep-Palm: 0.12
|
|
| 334 | - | - | - |
Deep-Palm: 0.31
|
|
| 378 | - | - | - |
Deep-Palm: 0.84
|
|
| 380 | - | - | - |
Deep-Palm: 0.73
|
|
| 385 | - | - | - |
Deep-Palm: 0.28
|
|
| 434 | - | - | - |
Deep-Palm: 0.33
|
|
| 447 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.80
|
|
| 535 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.90
|
|
| 553 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.95
|
|
| 607 | - | - | - |
Deep-Palm: 0.12
|
|
| 634 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.74
|
|
| 642 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.70
|
|
| 699 | - | - | - |
Deep-Palm: 0.67
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
4
cerebral cortex
Specificity: 0.500
4/4 (100.0%)
1
LNCaP
Specificity: 0.125
1/1 (100.0%)
1
HeLa cell
Specificity: 0.125
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 0.250
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 291 | R → C | 0.004283 | SNP | Missense Mutation | SKCM |
| 319 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 349 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 434 | C → C | 0.001764 | SNP | Silent | LUAD |
| 434 | C → C | 0.001887 | SNP | Silent | UCEC |
| 434 | C → C | 0.005618 | SNP | Silent | PAAD |