Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q8N3E9 PLCD3; KIAA1964 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC … Homo sapiens (Human) 789 aa

Protein Details: Q8N3E9 (PLCD3)

Protein Information
Accession Q8N3E9
Protein Names 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3)
Gene Symbol PLCD3; KIAA1964
Organism Homo sapiens (Human)
Length 789 aa
Isoforms No isoforms
Related PMIDs 19801377 29575903 31251020 32944167 36430497
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.267
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
4
LNCaP cells
Specificity: 0.267
4/46 (8.7%)
4
PC3 cells
Specificity: 0.267
4/4 (100.0%)
4
Cerebral cortex
Specificity: 0.267
4/4 (100.0%)
2
DU145 cells
Specificity: 0.133
2/2 (100.0%)
1
HeLa cells
Specificity: 0.067
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MLCGRWRRCR11RPPEEPPVAA21QVAAQVAAPV31ALPSPPTPSD41GGTKRPGLRA
51-10051LKKMGLTEDE61DVRAMLRGSR71LRKIRSRTWH81KERLYRLQED91GLSVWFQRRI
101-150101PRAPSQHIFF111VQHIEAVREG121HQSEGLRRFG131GAFAPARCLT141IAFKGRRKNL
151-200151DLAAPTAEEA161QRWVRGLTKL171RARLDAMSQR181ERLDHWIHSY191LHRADSNQDS
201-250201KMSFKEIKSL211LRMVNVDMND221MYAYLLFKEC231DHSNNDRLEG241AEIEEFLRRL
251-300251LKRPELEEIF261HQYSGEDRVL271SAPELLEFLE281DQGEEGATLA291RAQQLIQTYE
301-350301LNETAKQHEL311MTLDGFMMYL321LSPEGAALDN331THTCVFQDMN341QPLAHYFISS
351-400351SHNTYLTDSQ361IGGPSSTEAY371VRAFAQGCRC381VELDCWEGPG391GEPVIYHGHT
401-450401LTSKILFRDV411VQAVRDHAFT421LSPYPVILSL431ENHCGLEQQA441AMARHLCTIL
451-500451GDMLVTQALD461SPNPEELPSP471EQLKGRVLVK481GKKLPAARSE491DGRALSDREE
501-550501EEEDDEEEEE511EVEAAAQRRL521AKQISPELSA531LAVYCHATRL541RTLHPAPNAP
551-600551QPCQVSSLSE561RKAKKLIREA571GNSFVRHNAR581QLTRVYPLGL591RMNSANYSPQ
601-650601EMWNSGCQLV611ALNFQTPGYE621MDLNAGRFLV631NGQCGYVLKP641ACLRQPDSTF
651-700651DPEYPGPPRT661TLSIQVLTAQ671QLPKLNAEKP681HSIVDPLVRI691EIHGVPADCA
701-750701RQETDYVLNN711GFNPRWGQTL721QFQLRAPELA731LVRFVVEDYD741ATSPNDFVGQ
751-789751FTLPLSSLKQ761GYRHIHLLSK771DGASLSPATL781FIQIRIQRS
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
3 Prediction (High) - -
9 Prediction (Low) - -
138 Prediction (High) - -
447 Prediction (Low) - -
535 Prediction (Medium) - -
634 Prediction (Medium) - -
642 Prediction (Medium) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
291 R → C 0.004283 SNP Missense Mutation SKCM
319 Y → C 0.001887 SNP Missense Mutation UCEC
349 S → C 0.002427 SNP Missense Mutation BLCA
434 C → C 0.001764 SNP Silent LUAD
434 C → C 0.001887 SNP Silent UCEC
434 C → C 0.005618 SNP Silent PAAD