Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q8NBP7 | PCSK9 | Proprotein convertase subtilisin/kexin type 9 … | Homo sapiens (Human) | 692 aa |
Protein Details: Q8NBP7 (PCSK9)
Protein Information
| Accession | Q8NBP7 |
|---|---|
| Protein Names | Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) |
| Gene Symbol | PCSK9 |
| Organism | Homo sapiens (Human) |
| Length | 692 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | PTMD |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGTVSSRRSW11WPLPLLLLLL21LLLGPAGARA31QEDEDGDYEE41LVLALRSEED
51-10051GLAEAPEHGT61TATFHRCAKD71PWRLPGTYVV81VLKEETHLSQ91SERTARRLQA
101-150101QAARRGYLTK111ILHVFHGLLP121GFLVKMSGDL131LELALKLPHV141DYIEEDSSVF
151-200151AQSIPWNLER161ITPPRYRADE171YQPPDGGSLV181EVYLLDTSIQ191SDHREIEGRV
201-250201MVTDFENVPE211EDGTRFHRQA221SKCDSHGTHL231AGVVSGRDAG241VAKGASMRSL
251-300251RVLNCQGKGT261VSGTLIGLEF271IRKSQLVQPV281GPLVVLLPLA291GGYSRVLNAA
301-350301CQRLARAGVV311LVTAAGNFRD321DACLYSPASA331PEVITVGATN341AQDQPVTLGT
351-400351LGTNFGRCVD361LFAPGEDIIG371ASSDCSTCFV381SQSGTSQAAA391HVAGIAAMML
401-450401SAEPELTLAE411LRQRLIHFSA421KDVINEAWFP431EDQRVLTPNL441VAALPPSTHG
451-500451AGWQLFCRTV461WSAHSGPTRM471ATAVARCAPD481EELLSCSSFS491RSGKRRGERM
501-550501EAQGGKLVCR511AHNAFGGEGV521YAIARCCLLP531QANCSVHTAP541PAEASMGTRV
551-600551HCHQQGHVLT561GCSSHWEVED571LGTHKPPVLR581PRGQPNQCVG591HREASIHASC
601-650601CHAPGLECKV611KEHGIPAPQE621QVTVACEEGW631TLTGCSALPG641TSHVLGAYAV
651-692651DNTCVVRSRD661VSTTGSTSEG671AVTAVAICCR681SRHLAQASQE691LQ
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 67 | - | - | - |
Deep-Palm: 0.93
|
|
| 223 | - | - | - |
Deep-Palm: 0.29
|
|
| 255 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.97
|
|
| 301 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.98
|
|
| 323 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.93
|
|
| 358 | - | - | - |
Deep-Palm: 0.92
|
|
| 375 | - | - | - |
Deep-Palm: 0.68
|
|
| 378 | - | - | - |
Deep-Palm: 0.74
|
|
| 457 | - | - | - |
Deep-Palm: 0.54
|
|
| 477 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.88
|
|
| 486 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.97
|
|
| 509 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.96
|
|
| 526 | - | - | - |
Deep-Palm: 0.63
|
|
| 527 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.80
|
|
| 534 | - | - | - |
Deep-Palm: 0.77
|
|
| 552 | - | - | - |
Deep-Palm: 0.09
|
|
| 562 | - | - | - |
Deep-Palm: 0.05
|
|
| 588 | - | - | - |
Deep-Palm: 0.15
|
|
| 600 | PTMD | Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain | - | - |
Deep-Palm: 0.21
|
| 601 | - | - | - |
Deep-Palm: 0.18
|
|
| 608 | - | - | - |
Deep-Palm: 0.31
|
|
| 626 | - | - | - |
Deep-Palm: 0.64
|
|
| 635 | - | - | - |
Deep-Palm: 0.49
|
|
| 654 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.82
|
|
| 678 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.91
|
|
| 679 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.89
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 93 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 303 | R → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 378 | C → delins* | 0.002294 | INS | Nonsense Mutation | OV |
| 654 | C → C | 0.001887 | SNP | Silent | UCEC |