Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q8NCG7-4 | DAGLB | Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC … | Homo sapiens (Human) | 543 aa |
Protein Details: Q8NCG7-4 (DAGLB)
Protein Information
| Accession | Q8NCG7-4 |
|---|---|
| Protein Names | Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta) |
| Gene Symbol | DAGLB |
| Organism | Homo sapiens (Human) |
| Length | 543 aa |
| Isoforms | |
| Related PMIDs | 29575903 31251020 32651440 36430497 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MPGMVLFGRR11WAIASDDLVF21PGFFELVVRV31LWWIGILTLY41LMHRGKLDCA
51-10051GGALLSSYLI61VLMILLAVVI71CTVSAIMCVS81MRGTICNPGP91RKSMSKLLYI
101-150101RLALFFPEMV111WASLGAAWVA121DGVQCDRTVV131NGIIATVVVR141TQIWCPATLR
151-200151RASPCFISNR161TISGTTKSLP171RWSAMPQGAP181SCRSRTTDYD191LVGGDQLNCH
201-250201FGSILHTTGL211QYRDFIHVSF221HDKVYELPFL231VALDHRKESV241VVAVRGTMSL
251-300251QDVLTDLSAE261SEVLDVECEV271QDRLAHKGIS281QAARYVYQRL291INDGILSQAF
301-350301SIAPEYRLVI311VGHSLGGGAA321ALLATMLRAA331YPQVRCYAFS341PPRGLWSKAL
351-400351QEYSQSFIVS361LVLGKDVIPR371LSVTNLEDLK381RRILRVVAHC391NKPKYKILLH
401-450401GLWYELFGGN411PNNLPTELDG421GDQEVLTQPL431LGEQSLLTRW441SPAYSFSSDS
451-500451PLDSSPKYPP461LYPPGRIIHL471QEEGASGRFG481CCSAAHYSAK491WSHEAEFSKI
501-543501LIGPKMLTDH511MPDILMRALD521SVVSDRAACV531SCPAQGVSSV541DVA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 49 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.95
|
|
| 71 | - | - | - |
Deep-Palm: 0.29
|
|
| 78 | - | - | - |
Deep-Palm: 0.51
|
|
| 86 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.64
|
|
| 125 | - | - | - |
Deep-Palm: 0.88
|
|
| 145 | - | - | - |
GPS-Palm: 0.89
|
|
| 155 | - | - | - |
GPS-Palm: 0.92
|
|
| 201 | - | - | - |
Deep-Palm: 0.84
|
|
| 202 | - | - | - |
Deep-Palm: 0.73
|
|
| 203 | - | - | - |
Deep-Palm: 0.89
|
|
| 260 | - | - | - |
Deep-Palm: 0.48
|
|
| 278 | - | - | - |
Deep-Palm: 0.09
|
|
| 304 | - | - | - |
Deep-Palm: 0.64
|
|
| 310 | - | - | - |
Deep-Palm: 0.75
|
|
| 311 | - | - | - |
Deep-Palm: 0.81
|
|
| 328 | - | - | - |
Deep-Palm: 0.29
|
|
| 390 | - | - | - |
GPS-Palm: 0.91
|
|
| 397 | - | - | - |
Deep-Palm: 0.86
|
|
| 465 | - | - | - |
Deep-Palm: 0.93
|
|
| 481 | - |
HeLa
(29575903)
| - | - | |
| 482 | - |
HeLa
(29575903)
| - | - | |
| 519 | - | - | - |
Deep-Palm: 0.93
|
|
| 610 | - | - | - |
Deep-Palm: 0.69
|
|
| 611 | - | - | - |
Deep-Palm: 0.66
|
|
| 658 | - | - | - |
Deep-Palm: 0.94
|
|
| 661 | - | - | - |
Deep-Palm: 0.36
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.375
3
LNCaP
Specificity: 0.375
3/3 (100.0%)
3
cerebral cortex
Specificity: 0.375
3/3 (100.0%)
1
HeLa cell
Specificity: 0.125
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.125
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 125 | C → C | 0.002288 | SNP | Silent | STAD |
| 125 | C → C | 0.001887 | SNP | Silent | UCEC |
| 191 | S → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 201 | C → C | 0.002020 | SNP | Silent | PRAD |
| 278 | C → C | 0.001887 | SNP | Silent | UCEC |
| 616 | Y → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 658 | C → C | 0.002506 | SNP | Silent | COAD |