Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q8NF37 | LPCAT1 | Lysophosphatidylcholine acyltransferase 1 (LPC acyltransferase … | Homo sapiens (Human) | 534 aa |
Protein Details: Q8NF37 (LPCAT1)
Protein Information
| Accession | Q8NF37 |
|---|---|
| Protein Names | Lysophosphatidylcholine acyltransferase 1 (LPC acyltransferase 1) (LPCAT-1) (LysoPC acyltransferase 1) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkenylglycerophosphocholine O-acyltransferase) (EC 2.3.1.25) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 2) (Phosphonoformate immuno-associated protein 3) |
| Gene Symbol | LPCAT1 |
| Organism | Homo sapiens (Human) |
| Length | 534 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MRLRGCGPRA11APASSAGASD21ARLLAPPGRN31PFVHELRLSA41LQKAQVALMT
51-10051LTLFPVRLLV61AAAMMLLAWP71LALVASLGSA81EKEPEQPPAL91WRKVVDFLLK
101-150101AIMRTMWFAG111GFHRVAVKGR121QALPTEAAIL131TLAPHSSYFD141AIPVTMTMSS
151-200151IVMKAESRDI161PIWGTLIQYI171RPVFVSRSDQ181DSRRKTVEEI191KRRAQSNGKW
201-250201PQIMIFPEGT211CTNRTCLITF221KPGAFIPGAP231VQPVVLRYPN241KLDTITWTWQ
251-300251GPGALEILWL261TLCQFHNQVE271IEFLPVYSPS281EEEKRNPALY291ASNVRRVMAE
301-350301ALGVSVTDYT311FEDCQLALAE321GQLRLPADTC331LLEFARLVRG341LGLKPEKLEK
351-400351DLDRYSERAR361MKGGEKIGIA371EFAASLEVPV381SDLLEDMFSL391FDESGSGEVD
401-450401LRECVVALSV411VCRPARTLDT421IQLAFKMYGA431QEDGSVGEGD441LSCILKTALG
451-500451VAELTVTDLF461RAIDQEEKGK471ITFADFHRFA481EMYPAFAEEY491LYPDQTHFES
501-534501CAETSPAPIP511NGFCADFSPE521NSDAGRKPVR531KKLD
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 6 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.14
|
|
| 211 | - |
HeLa
(37611173)
| - |
Deep-Palm: 0.71
|
|
| 216 | SWISSPALM DBPTM CYSMODDB | Acyltransferase |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
Deep-Palm: 0.92
|
| 263 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.87
|
|
| 314 | - | - | - |
Deep-Palm: 0.97
|
|
| 330 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.89
Deep-Palm: 0.99
|
|
| 404 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.65
Deep-Palm: 0.97
|
|
| 412 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.97
|
|
| 443 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.66
Deep-Palm: 0.98
|
|
| 501 | - | - | - |
Deep-Palm: 0.16
|
|
| 514 | - | - | - |
Deep-Palm: 0.59
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.600
3
LNCaP
Specificity: 0.600
3/3 (100.0%)
1
HAP1 cell
Specificity: 0.200
1/1 (100.0%)
1
293T cell
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 69 | W → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 104 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 150 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 290 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 428 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |