Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q8NF37 | LPCAT1; AYTL2; PFAAP3 | Lysophosphatidylcholine acyltransferase 1 (LPC acyltransferase … | Homo sapiens (Human) | 534 aa |
Protein Details: Q8NF37 (LPCAT1)
Protein Information
| Accession | Q8NF37 |
|---|---|
| Protein Names | Lysophosphatidylcholine acyltransferase 1 (LPC acyltransferase 1) (LPCAT-1) (LysoPC acyltransferase 1) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkenylglycerophosphocholine O-acyltransferase) (EC 2.3.1.25) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 2) (Phosphonoformate immuno-associated protein 3) |
| Gene Symbol | LPCAT1; AYTL2; PFAAP3 |
| Organism | Homo sapiens (Human) |
| Length | 534 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 29733200 31251020 32944167 36430497 37611173 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.676
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
25
LNCaP cells
Specificity: 0.676
25/46 (54.3%)
4
HAP1 cells
Specificity: 0.108
4/10 (40.0%)
4
293T cells
Specificity: 0.108
4/10 (40.0%)
3
PC3 cells
Specificity: 0.081
3/4 (75.0%)
1
Cerebral cortex
Specificity: 0.027
1/4 (25.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MRLRGCGPRA11APASSAGASD21ARLLAPPGRN31PFVHELRLSA41LQKAQVALMT
51-10051LTLFPVRLLV61AAAMMLLAWP71LALVASLGSA81EKEPEQPPAL91WRKVVDFLLK
101-150101AIMRTMWFAG111GFHRVAVKGR121QALPTEAAIL131TLAPHSSYFD141AIPVTMTMSS
151-200151IVMKAESRDI161PIWGTLIQYI171RPVFVSRSDQ181DSRRKTVEEI191KRRAQSNGKW
201-250201PQIMIFPEGT211CTNRTCLITF221KPGAFIPGAP231VQPVVLRYPN241KLDTITWTWQ
251-300251GPGALEILWL261TLCQFHNQVE271IEFLPVYSPS281EEEKRNPALY291ASNVRRVMAE
301-350301ALGVSVTDYT311FEDCQLALAE321GQLRLPADTC331LLEFARLVRG341LGLKPEKLEK
351-400351DLDRYSERAR361MKGGEKIGIA371EFAASLEVPV381SDLLEDMFSL391FDESGSGEVD
401-450401LRECVVALSV411VCRPARTLDT421IQLAFKMYGA431QEDGSVGEGD441LSCILKTALG
451-500451VAELTVTDLF461RAIDQEEKGK471ITFADFHRFA481EMYPAFAEEY491LYPDQTHFES
501-534501CAETSPAPIP511NGFCADFSPE521NSDAGRKPVR531KKLD
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 6 | Prediction (High) | - | - |
| 211 | Experimental | Acyltransferase | 37611173 |
| 216 | Experimental CYSMODDB SWISSPALM DBPTM | Acyltransferase | 29575903 |
| 263 | Prediction (Low) | - | - |
| 330 | Prediction (Medium) | - | - |
| 404 | Experimental Prediction (Low) | - | 37611173 |
| 412 | Prediction (Medium) | - | - |
| 443 | Prediction (Low) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 69 | W → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 104 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 150 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 290 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 428 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |