Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q8NFJ5 | GPRC5A | Retinoic acid-induced protein 3 (G-protein … | Homo sapiens (Human) | 357 aa |
Protein Details: Q8NFJ5 (GPRC5A)
Protein Information
| Accession | Q8NFJ5 |
|---|---|
| Protein Names | Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1) |
| Gene Symbol | GPRC5A |
| Organism | Homo sapiens (Human) |
| Length | 357 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 24357059 29575903 |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MATTVPDGCR11NGLKSKYYRL21CDKAEAWGIV31LETVATAGVV41TSVAFMLTLP
51-10051ILVCKVQDSN61RRKMLPTQFL71FLLGVLGIFG81LTFAFIIGLD91GSTGPTRFFL
101-150101FGILFSICFS111CLLAHAVSLT121KLVRGRKPLS131LLVILGLAVG141FSLVQDVIAI
151-200151EYIVLTMNRT161NVNVFSELSA171PRRNEDFVLL181LTYVLFLMAL191TFLMSSFTFC
201-250201GSFTGWKRHG211AHIYLTMLLS221IAIWVAWITL231LMLPDFDRRW241DDTILSSALA
251-300251ANGWVFLLAY261VSPEFWLLTK271QRNPMDYPVE281DAFCKPQLVK291KSYGVENRAY
301-350301SQEEITQGFE311ETGDTLYAPY321STHFQLQNQP331PQKEFSIPRA341HAWPSPYKDY
351-357351EVKKEGS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 9 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.05
|
| 21 | Retinoic acid-inducible GPCR family 3 | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.86
|
|
| 54 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.89
|
|
| 108 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.72
|
|
| 111 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.85
|
|
| 200 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.40
|
|
| 284 | DBPTM SWISSPALM | - |
HeLa
(37611173)
| - |
Deep-Palm: 0.76
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
2
HeLa cell
Specificity: 0.500
2/2 (100.0%)
1
EC cell
Specificity: 0.250
1/1 (100.0%)
1
HUVECs
Specificity: 0.250
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 110 | S → Cfs*42 | 0.001764 | INS | Frame Shift Ins | LUAD |
| 172 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| ? | ? → ? | 0.002545 | SNP | Missense Mutation | GBM |
| ? | ? → ? | 0.001887 | SNP | Silent | UCEC |