Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q8NHU3 | SGMS2; SMS2 | Phosphatidylcholine:ceramide cholinephosphotransferase 2 (EC 2.7.8.27) … | Homo sapiens (Human) | 365 aa |
Protein Details: Q8NHU3 (SGMS2)
Protein Information
| Accession | Q8NHU3 |
|---|---|
| Protein Names | Phosphatidylcholine:ceramide cholinephosphotransferase 2 (EC 2.7.8.27) (Sphingomyelin synthase 2) (SMS2) |
| Gene Symbol | SGMS2; SMS2 |
| Organism | Homo sapiens (Human) |
| Length | 365 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 |
| Database Sources | dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
25
LNCaP cells
Specificity: 1.000
25/46 (54.3%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MDIIETAKLE11EHLENQPSDP21TNTYARPAEP31VEEENKNGNG41KPKSLSSGLR
51-10051KGTKKYPDYI61QIAMPTESRN71KFPLEWWKTG81IAFIYAVFNL91VLTTVMITVV
101-150101HERVPPKELS111PPLPDKFFDY121IDRVKWAFSV131SEINGIILVG141LWITQWLFLR
151-200151YKSIVGRRFC161FIIGTLYLYR171CITMYVTTLP181VPGMHFQCAP191KLNGDSQAKV
201-250201QRILRLISGG211GLSITGSHIL221CGDFLFSGHT231VTLTLTYLFI241KEYSPRHFWW
251-300251YHLICWLLSA261AGIICILVAH271EHYTIDVIIA281YYITTRLFWW291YHSMANEKNL
301-350301KVSSQTNFLS311RAWWFPIFYF321FEKNVQGSIP331CCFSWPLSWP341PGCFKSSCKK
351-365351YSRVQKIGED361NEKST
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 160 | Prediction (High) | - | - |
| 331 | DBPTM SWISSPALM Prediction (Medium) | - | - |
| 332 | DBPTM SWISSPALM Prediction (Medium) | - | - |
| 343 | DBPTM SWISSPALM Prediction (Medium) | - | - |
| 348 | DBPTM SWISSPALM Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 171 | C → Y | 0.002506 | SNP | Missense Mutation | COAD |
| 246 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 265 | C → Y | 0.002294 | SNP | Missense Mutation | OV |
| 332 | C → _F333insLQ | 0.001014 | INS | In Frame Ins | BRCA |
| 332 | C → _F333insLQ | 0.001887 | INS | In Frame Ins | UCEC |
| 348 | C → R | 0.002288 | SNP | Missense Mutation | STAD |
| 331* | C → ? | 0.007299 | SNP | Nonsense Mutation | READ |
| 255* | C → ? | 0.001887 | SNP | Nonsense Mutation | UCEC |