Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q8NHU3 | SGMS2 | Phosphatidylcholine:ceramide cholinephosphotransferase 2 (EC 2.7.8.27) … | Homo sapiens (Human) | 365 aa |
Protein Details: Q8NHU3 (SGMS2)
Protein Information
| Accession | Q8NHU3 |
|---|---|
| Protein Names | Phosphatidylcholine:ceramide cholinephosphotransferase 2 (EC 2.7.8.27) (Sphingomyelin synthase 2) (SMS2) |
| Gene Symbol | SGMS2 |
| Organism | Homo sapiens (Human) |
| Length | 365 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MDIIETAKLE11EHLENQPSDP21TNTYARPAEP31VEEENKNGNG41KPKSLSSGLR
51-10051KGTKKYPDYI61QIAMPTESRN71KFPLEWWKTG81IAFIYAVFNL91VLTTVMITVV
101-150101HERVPPKELS111PPLPDKFFDY121IDRVKWAFSV131SEINGIILVG141LWITQWLFLR
151-200151YKSIVGRRFC161FIIGTLYLYR171CITMYVTTLP181VPGMHFQCAP191KLNGDSQAKV
201-250201QRILRLISGG211GLSITGSHIL221CGDFLFSGHT231VTLTLTYLFI241KEYSPRHFWW
251-300251YHLICWLLSA261AGIICILVAH271EHYTIDVIIA281YYITTRLFWW291YHSMANEKNL
301-350301KVSSQTNFLS311RAWWFPIFYF321FEKNVQGSIP331CCFSWPLSWP341PGCFKSSCKK
351-365351YSRVQKIGED361NEKST
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 160 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.26
|
|
| 171 | - | - | - |
Deep-Palm: 0.18
|
|
| 188 | - | - | - |
Deep-Palm: 0.49
|
|
| 221 | - | - | - |
Deep-Palm: 0.71
|
|
| 255 | - | - | - |
Deep-Palm: 0.07
|
|
| 265 | - | - | - |
Deep-Palm: 0.06
|
|
| 331 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.21
|
| 332 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.23
|
| 343 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.50
|
| 348 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.61
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
LNCaP
Specificity: 1.000
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 171 | C → Y | 0.002506 | SNP | Missense Mutation | COAD |
| 246 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 265 | C → Y | 0.002294 | SNP | Missense Mutation | OV |
| 332 | C → _F333insLQ | 0.001014 | INS | In Frame Ins | BRCA |
| 332 | C → _F333insLQ | 0.001887 | INS | In Frame Ins | UCEC |
| 348 | C → R | 0.002288 | SNP | Missense Mutation | STAD |
| 331* | C → ? | 0.007299 | SNP | Nonsense Mutation | READ |
| 255* | C → ? | 0.001887 | SNP | Nonsense Mutation | UCEC |