Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q8TCG2 | PI4K2B | Phosphatidylinositol 4-kinase type 2-beta (EC … | Homo sapiens (Human) | 481 aa |
Protein Details: Q8TCG2 (PI4K2B)
Protein Information
| Accession | Q8TCG2 |
|---|---|
| Protein Names | Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA) |
| Gene Symbol | PI4K2B |
| Organism | Homo sapiens (Human) |
| Length | 481 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 26111759 31251020 31382980 32651440 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEDPSEPDRL11ASADGGSPEE21EEDGEREPLL31PRIAWAHPRR41GAPGSAVRLL
51-10051DAAGEEGEAG61DEELPLPPGD71VGVSRSSSAE81LDRSRPAVSV91TIGTSEMNAF
101-150101LDDPEFADIM111LRAEQAIEVG121IFPERISQGS131SGSYFVKDPK141RKIIGVFKPK
151-200151SEEPYGQLNP161KWTKYVHKVC171CPCCFGRGCL181IPNQGYLSEA191GAYLVDNKLH
201-250201LSIVPKTKVV211WLVSETFNYN221AIDRAKSRGK231KYALEKVPKV241GRKFHRIGLP
251-300251PKIGSFQLFV261EGYKEAEYWL271RKFEADPLPE281NIRKQFQSQF291ERLVILDYII
301-350301RNTDRGNDNW311LVRYEKQKCE321KEIDHKESKW331IDDEEFLIKI341AAIDNGLAFP
351-400351FKHPDEWRAY361PFHWAWLPQA371KVPFSEEIRN381LILPYISDMN391FVQDLCEDLY
401-450401ELFKTDKGFD411KATFESQMSV421MRGQILNLTQ431ALRDGKSPFQ441LVQIPCVIVE
451-481451RSQGGSQGRI461VHLSNSFTQT471VNCRKPFFSS481W
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 170 | DBPTM SWISSPALM | Phosphatidylinositol 3- and 4-kinase | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.09
|
| 171 | DBPTM SWISSPALM | Phosphatidylinositol 3- and 4-kinase | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.09
|
| 173 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.13
|
| 174 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.10
|
| 179 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.37
|
|
| 319 | - | - | - |
Deep-Palm: 0.13
|
|
| 396 | - | - | - |
Deep-Palm: 0.47
|
|
| 446 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.78
Deep-Palm: 0.95
|
|
| 473 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.01
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
8
Jurkat T cell
Specificity: 0.421
8/8 (100.0%)
4
LNCaP
Specificity: 0.211
4/4 (100.0%)
3
PC3
Specificity: 0.158
3/3 (100.0%)
2
Primary T cell
Specificity: 0.105
2/2 (100.0%)
1
U937 cell
Specificity: 0.053
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.053
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 174 | C → W | 0.002545 | SNP | Missense Mutation | GBM |
| 259 | F → C | 0.002545 | SNP | Missense Mutation | GBM |
| 319 | C → C | 0.001887 | SNP | Silent | UCEC |
| 451 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 174* | C → ? | 0.001969 | SNP | Nonsense Mutation | LGG |