Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q8TCG2 | PI4K2B | Phosphatidylinositol 4-kinase type 2-beta (EC … | Homo sapiens (Human) | 481 aa |
Protein Details: Q8TCG2 (PI4K2B)
Protein Information
| Accession | Q8TCG2 |
|---|---|
| Protein Names | Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA) |
| Gene Symbol | PI4K2B |
| Organism | Homo sapiens (Human) |
| Length | 481 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 26111759 31251020 31382980 32651440 32944167 |
| Database Sources | dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.725
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
37
LNCaP cells
Specificity: 0.725
37/46 (80.4%)
6
Jurkat T cells
Specificity: 0.118
6/25 (24.0%)
3
PC3 cells
Specificity: 0.059
3/4 (75.0%)
2
DU145 cells
Specificity: 0.039
2/2 (100.0%)
2
T cells
Specificity: 0.039
2/4 (50.0%)
1
U937 cells
Specificity: 0.020
1/1 (100.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MEDPSEPDRL11ASADGGSPEE21EEDGEREPLL31PRIAWAHPRR41GAPGSAVRLL
51-10051DAAGEEGEAG61DEELPLPPGD71VGVSRSSSAE81LDRSRPAVSV91TIGTSEMNAF
101-150101LDDPEFADIM111LRAEQAIEVG121IFPERISQGS131SGSYFVKDPK141RKIIGVFKPK
151-200151SEEPYGQLNP161KWTKYVHKVC171CPCCFGRGCL181IPNQGYLSEA191GAYLVDNKLH
201-250201LSIVPKTKVV211WLVSETFNYN221AIDRAKSRGK231KYALEKVPKV241GRKFHRIGLP
251-300251PKIGSFQLFV261EGYKEAEYWL271RKFEADPLPE281NIRKQFQSQF291ERLVILDYII
301-350301RNTDRGNDNW311LVRYEKQKCE321KEIDHKESKW331IDDEEFLIKI341AAIDNGLAFP
351-400351FKHPDEWRAY361PFHWAWLPQA371KVPFSEEIRN381LILPYISDMN391FVQDLCEDLY
401-450401ELFKTDKGFD411KATFESQMSV421MRGQILNLTQ431ALRDGKSPFQ441LVQIPCVIVE
451-481451RSQGGSQGRI461VHLSNSFTQT471VNCRKPFFSS481W
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 170 | DBPTM SWISSPALM Prediction (High) | Phosphatidylinositol 3- and 4-kinase | - |
| 171 | DBPTM SWISSPALM Prediction (High) | Phosphatidylinositol 3- and 4-kinase | - |
| 173 | DBPTM SWISSPALM Prediction (High) | - | - |
| 174 | DBPTM SWISSPALM Prediction (High) | - | - |
| 179 | Prediction (Medium) | - | - |
| 446 | Prediction (Medium) | - | - |
| 473 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 174 | C → W | 0.002545 | SNP | Missense Mutation | GBM |
| 259 | F → C | 0.002545 | SNP | Missense Mutation | GBM |
| 319 | C → C | 0.001887 | SNP | Silent | UCEC |
| 451 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 174* | C → ? | 0.001969 | SNP | Nonsense Mutation | LGG |