Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q8TCT8 SPPL2A; IMP3; PSL2; PSEC0147 Signal peptide peptidase-like 2A (SPP-like … Homo sapiens (Human) 520 aa

Protein Details: Q8TCT8 (SPPL2A)

Protein Information
Accession Q8TCT8
Protein Names Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2)
Gene Symbol SPPL2A; IMP3; PSL2; PSEC0147
Organism Homo sapiens (Human)
Length 520 aa
Isoforms No isoforms
Related PMIDs 26111759 29575903 31251020 33636221 37611173
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
16
LNCaP cells
Specificity: 0.800
16/46 (34.8%)
3
T cells
Specificity: 0.150
3/4 (75.0%)
1
Liver membrane
Specificity: 0.050
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGPQRRLSPA11GAALLWGFLL21QLTAAQEAIL31HASGNGTTKD41YCMLYNPYWT
51-10051ALPSTLENAT61SISLMNLTST71PLCNLSDIPP81VGIKSKAVVV91PWGSCHFLEK
101-150101ARIAQKGGAE111AMLVVNNSVL121FPPSGNRSEF131PDVKILIAFI141SYKDFRDMNQ
151-200151TLGDNITVKM161YSPSWPNFDY171TMVVIFVIAV181FTVALGGYWS191GLVELENLKA
201-250201VTTEDREMRK211KKEEYLTFSP221LTVVIFVVIC231CVMMVLLYFF241YKWLVYVMIA
251-300251IFCIASAMSL261YNCLAALIHK271IPYGQCTIAC281RGKNMEVRLI291FLSGLCIAVA
301-350301VVWAVFRNED311RWAWILQDIL321GIAFCLNLIK331TLKLPNFKSC341VILLGLLLLY
351-400351DVFFVFITPF361ITKNGESIMV371ELAAGPFGNN381EKLPVVIRVP391KLIYFSVMSV
401-450401CLMPVSILGF411GDIIVPGLLI421AYCRRFDVQT431GSSYIYYVSS441TVAYAIGMIL
451-500451TFVVLVLMKK461GQPALLYLVP471CTLITASVVA481WRRKEMKKFW491KGNSYQMMDH
501-520501LDCATNEENP511VISGEQIVQQ
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
95 Experimental CYSMODDB SWISSPALM DBPTM Prediction (Medium) PA domain 29575903
263 Prediction (Medium) - -
276 Experimental Prediction (Medium) - 37611173
296 Prediction (Low) - -
325 Prediction (Medium) - -
340 Prediction (High) - -
401 Prediction (Low) - -
423 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
41 Y → C 0.001764 SNP Missense Mutation LUAD
76 S → C 0.002033 SNP Missense Mutation LUSC
108 G → C 0.001887 SNP Missense Mutation UCEC
253 C → F 0.001764 SNP Missense Mutation LUAD
434 Y → C 0.002288 SNP Missense Mutation STAD
440 S → C 0.002033 SNP Missense Mutation LUSC
490 W → C 0.002427 SNP Missense Mutation BLCA
401* C → ? 0.001014 SNP Nonsense Mutation BRCA