Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q8TCT8 | SPPL2A | Signal peptide peptidase-like 2A (SPP-like … | Homo sapiens (Human) | 520 aa |
Protein Details: Q8TCT8 (SPPL2A)
Protein Information
| Accession | Q8TCT8 |
|---|---|
| Protein Names | Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2) |
| Gene Symbol | SPPL2A |
| Organism | Homo sapiens (Human) |
| Length | 520 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26111759 31251020 33636221 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGPQRRLSPA11GAALLWGFLL21QLTAAQEAIL31HASGNGTTKD41YCMLYNPYWT
51-10051ALPSTLENAT61SISLMNLTST71PLCNLSDIPP81VGIKSKAVVV91PWGSCHFLEK
101-150101ARIAQKGGAE111AMLVVNNSVL121FPPSGNRSEF131PDVKILIAFI141SYKDFRDMNQ
151-200151TLGDNITVKM161YSPSWPNFDY171TMVVIFVIAV181FTVALGGYWS191GLVELENLKA
201-250201VTTEDREMRK211KKEEYLTFSP221LTVVIFVVIC231CVMMVLLYFF241YKWLVYVMIA
251-300251IFCIASAMSL261YNCLAALIHK271IPYGQCTIAC281RGKNMEVRLI291FLSGLCIAVA
301-350301VVWAVFRNED311RWAWILQDIL321GIAFCLNLIK331TLKLPNFKSC341VILLGLLLLY
351-400351DVFFVFITPF361ITKNGESIMV371ELAAGPFGNN381EKLPVVIRVP391KLIYFSVMSV
401-450401CLMPVSILGF411GDIIVPGLLI421AYCRRFDVQT431GSSYIYYVSS441TVAYAIGMIL
451-500451TFVVLVLMKK461GQPALLYLVP471CTLITASVVA481WRRKEMKKFW491KGNSYQMMDH
501-520501LDCATNEENP511VISGEQIVQQ
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 42 | - | - | - |
Deep-Palm: 0.21
|
|
| 73 | - | - | - |
Deep-Palm: 0.91
|
|
| 95 | SWISSPALM DBPTM CYSMODDB | PA domain | - |
LNCaP
(31251020)
|
GPS-Palm: 0.80
Deep-Palm: 0.97
|
| 230 | - | - | - |
Deep-Palm: 0.04
|
|
| 231 | - | - | - |
Deep-Palm: 0.04
|
|
| 253 | - | - | - |
Deep-Palm: 0.03
|
|
| 263 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.13
|
|
| 276 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.87
Deep-Palm: 0.45
|
|
| 280 | - | - | - |
Deep-Palm: 0.77
|
|
| 296 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.70
|
|
| 325 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.84
|
|
| 340 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.97
|
|
| 401 | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.56
|
|
| 423 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.54
|
|
| 471 | - | - | - |
Deep-Palm: 0.97
|
|
| 503 | - | - | - |
Deep-Palm: 0.05
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
3
Primary T cell
Specificity: 0.429
3/3 (100.0%)
2
LNCaP
Specificity: 0.286
2/2 (100.0%)
1
heart
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.143
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 41 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 76 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 108 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 253 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |
| 434 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 440 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 490 | W → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 401* | C → ? | 0.001014 | SNP | Nonsense Mutation | BRCA |