Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q8WU20 | FRS2 | Fibroblast growth factor receptor substrate … | Homo sapiens (Human) | 508 aa |
Protein Details: Q8WU20 (FRS2)
Protein Information
| Accession | Q8WU20 |
|---|---|
| Protein Names | Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) |
| Gene Symbol | FRS2 |
| Organism | Homo sapiens (Human) |
| Length | 508 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGSCCSCPDK11DTVPDNHRNK21FKVINVDDDG31NELGSGIMEL41TDTELILYTR
51-10051KRDSVKWHYL61CLRRYGYDSN71LFSFESGRRC81QTGQGIFAFK91CARAEELFNM
101-150101LQEIMQNNSI111NVVEEPVVER121NNHQTELEVP131RTPRTPTTPG141FAAQNLPNGY
151-200151PRYPSFGDAS161SHPSSRHPSV171GSARLPSVGE181ESTHPLLVAE191EQVHTYVNTT
201-250201GVQEERKNRT211SVHVPLEARV221SNAESSTPKE231EPSSIEDRDP241QILLEPEGVK
251-300251FVLGPTPVQK261QLMEKEKLEQ271LGRDQVSGSG281ANNTEWDTGY291DSDERRDAPS
301-350301VNKLVYENIN311GLSIPSASGV321RRGRLTSTST331SDTQNINNSA341QRRTALLNYE
351-400351NLPSLPPVWE361ARKLSRDEDD371NLGPKTPSLN381GYHNNLDPMH391NYVNTENVTV
401-450401PASAHKIEYS411RRRDCTPTVF421NFDIRRPSLE431HRQLNYIQVD441LEGGSDSDNP
451-500451QTPKTPTTPL461PQTPTRRTEL471YAVIDIERTA481AMSNLQKALP491RDDGTSRKTR
501-508501HNSTDLPM
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 4 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.01
|
| 5 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.01
|
| 7 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.01
|
|
| 61 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.25
|
|
| 80 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.67
Deep-Palm: 0.58
|
|
| 91 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.65
|
|
| 415 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.64
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
PC3
Specificity: 0.500
4/4 (100.0%)
3
LNCaP
Specificity: 0.375
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.125
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 21 | F → C | 0.003559 | SNP | Missense Mutation | KIRP |
| 174 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 221 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 306 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 324 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 436 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |
| 467 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 496 | S → C | 0.002020 | SNP | Missense Mutation | PRAD |