Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q8WU20 FRS2 Fibroblast growth factor receptor substrate … Homo sapiens (Human) 508 aa

Protein Details: Q8WU20 (FRS2)

Protein Information
Accession Q8WU20
Protein Names Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)
Gene Symbol FRS2
Organism Homo sapiens (Human)
Length 508 aa
Isoforms No isoforms
Related PMIDs 31251020 32944167
Database Sources dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.862
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
25
LNCaP cells
Specificity: 0.862
25/46 (54.3%)
4
PC3 cells
Specificity: 0.138
4/4 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGSCCSCPDK11DTVPDNHRNK21FKVINVDDDG31NELGSGIMEL41TDTELILYTR
51-10051KRDSVKWHYL61CLRRYGYDSN71LFSFESGRRC81QTGQGIFAFK91CARAEELFNM
101-150101LQEIMQNNSI111NVVEEPVVER121NNHQTELEVP131RTPRTPTTPG141FAAQNLPNGY
151-200151PRYPSFGDAS161SHPSSRHPSV171GSARLPSVGE181ESTHPLLVAE191EQVHTYVNTT
201-250201GVQEERKNRT211SVHVPLEARV221SNAESSTPKE231EPSSIEDRDP241QILLEPEGVK
251-300251FVLGPTPVQK261QLMEKEKLEQ271LGRDQVSGSG281ANNTEWDTGY291DSDERRDAPS
301-350301VNKLVYENIN311GLSIPSASGV321RRGRLTSTST331SDTQNINNSA341QRRTALLNYE
351-400351NLPSLPPVWE361ARKLSRDEDD371NLGPKTPSLN381GYHNNLDPMH391NYVNTENVTV
401-450401PASAHKIEYS411RRRDCTPTVF421NFDIRRPSLE431HRQLNYIQVD441LEGGSDSDNP
451-500451QTPKTPTTPL461PQTPTRRTEL471YAVIDIERTA481AMSNLQKALP491RDDGTSRKTR
501-508501HNSTDLPM
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
4 DBPTM SWISSPALM Prediction (High) - -
5 DBPTM SWISSPALM Prediction (High) - -
7 Prediction (Low) - -
61 Prediction (Low) - -
80 Prediction (Low) - -
91 Prediction (Low) - -
415 Prediction (Low) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
21 F → C 0.003559 SNP Missense Mutation KIRP
174 R → C 0.001887 SNP Missense Mutation UCEC
221 S → C 0.001014 SNP Missense Mutation BRCA
306 Y → C 0.001887 SNP Missense Mutation UCEC
324 R → C 0.007299 SNP Missense Mutation READ
436 Y → C 0.002506 SNP Missense Mutation COAD
467 R → C 0.002288 SNP Missense Mutation STAD
496 S → C 0.002020 SNP Missense Mutation PRAD