Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q91Y47 | F11 | Coagulation factor XI (FXI) (EC … | Mus musculus (Mouse) | 624 aa |
Protein Details: Q91Y47 (F11)
Protein Information
| Accession | Q91Y47 |
|---|---|
| Protein Names | Coagulation factor XI (FXI) (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain] |
| Gene Symbol | F11 |
| Organism | Mus musculus (Mouse) |
| Length | 624 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29217618 (mass) 31311849 (mass) 31772009 (mass) 34884899 (mass) 35358180 (mass) 37925639 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MTSLHQVLYF11IFFASVSSEC21VTKVFKDISF31QGGDLSTVFT41PSATYCRLVC
51-10051THHPRCLLFT61FMAESSSDDP71TKWFACILKD81SVTEILPMVN91MTGAISGYSF
101-150101KQCPQQLSTC111SKDVYVNLDM121KGMNYNSSVV131KNARECQERC141TDDAHCQFFT
151-200151YATGYFPSVD161HRKMCLLKYT171RTGTPTTITK181LNGVVSGFSL191KSCGLSNLAC
201-250201IRDIFPNTVL211ADLNIDSVVA221PDAFVCRRIC231THHPTCLFFT241FFSQAWPKES
251-300251QRHLCLLKTS261ESGLPSTRIT271KSHALSGFSL281QHCRHSVPVF291CHPSFYNDTD
301-350301FLGEELDIVD311VKGQETCQKT321CTNNARCQFF331TYYPSHRLCN341ERNRRGRCYL
351-400351KLSSNGSPTR361ILHGRGGISG371YSLRLCKMDN381VCTTKINPRV391VGGAASVHGE
401-450401WPWQVTLHIS411QGHLCGGSII421GNQWILTAAH431CFSGIETPKK441LRVYGGIVNQ
451-500451SEINEGTAFF461RVQEMIIHDQ471YTTAESGYDI481ALLKLESAMN491YTDFQRPICL
501-550501PSKGDRNAVH511TECWVTGWGY521TALRGEVQST531LQKAKVPLVS541NEECQTRYRR
551-600551HKITNKMICA561GYKEGGKDTC571KGDSGGPLSC581KYNGVWHLVG591ITSWGEGCGQ
601-624601KERPGVYTNV611AKYVDWILEK621TQTV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 20 | - | - | - |
Deep-Palm: 0.46
|
|
| 46 | Hepatocyte Growth Factor Apple domain | - | - |
Deep-Palm: 0.19
|
|
| 50 | Hepatocyte Growth Factor Apple domain | - | - |
Deep-Palm: 0.07
|
|
| 56 | - | - | - |
Deep-Palm: 0.05
|
|
| 76 | - | - | - |
Deep-Palm: 0.63
|
|
| 103 | - | - | - |
Deep-Palm: 0.26
|
|
| 110 | - | - | - |
Deep-Palm: 0.18
|
|
| 136 | - | - | - |
Deep-Palm: 0.02
|
|
| 140 | - | - | - |
Deep-Palm: 0.02
|
|
| 146 | - | - | - |
Deep-Palm: 0.02
|
|
| 165 | - | - | - |
Deep-Palm: 0.69
|
|
| 193 | - | - |
Brain
(35358180)
|
GPS-Palm: 0.95
Deep-Palm: 0.87
|
|
| 200 | - | - |
Brain
(35358180)
|
GPS-Palm: 0.92
Deep-Palm: 0.96
|
|
| 226 | - | - | - |
Deep-Palm: 0.04
|
|
| 230 | - | - | - |
Deep-Palm: 0.03
|
|
| 236 | - | - | - |
Deep-Palm: 0.03
|
|
| 255 | - | - | - |
Deep-Palm: 0.92
|
|
| 283 | - | - | - |
Deep-Palm: 0.18
|
|
| 291 | - | - | - |
Deep-Palm: 0.18
|
|
| 317 | - | - | - |
Deep-Palm: 0.06
|
|
| 321 | - | - | - |
Deep-Palm: 0.03
|
|
| 327 | SWISSPALM DBPTM CYSMODDB | PAN domain |
liver
(26165157)
| - |
Deep-Palm: 0.04
|
| 339 | - | - | - |
Deep-Palm: 0.37
|
|
| 348 | - | - | - |
Deep-Palm: 0.73
|
|
| 376 | - | - | - |
Deep-Palm: 0.81
|
|
| 382 | - | - | - |
Deep-Palm: 0.85
|
|
| 415 | - | - | - |
Deep-Palm: 0.08
|
|
| 431 | - | - | - |
Deep-Palm: 0.45
|
|
| 499 | - | - | - |
Deep-Palm: 0.26
|
|
| 513 | - | - | - |
Deep-Palm: 0.23
|
|
| 544 | SWISSPALM DBPTM CYSMODDB | Trypsin |
liver
(26165157)
| - |
Deep-Palm: 0.93
|
| 559 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.22
|
|
| 570 | - | - | - |
Deep-Palm: 0.13
|
|
| 580 | - | - | - |
Deep-Palm: 0.23
|
|
| 598 | - | - | - |
Deep-Palm: 0.26
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Brain tissue (Mass)
Specificity: 1.000
2/56 (3.6%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 50 | C → C | 0.001887 | SNP | Silent | UCEC |
| 129 | V → Cfs*14 | 0.002294 | DEL | Frame Shift Del | OV |
| 136 | C → W | 0.001764 | SNP | Missense Mutation | LUAD |
| 165 | C → C | 0.001887 | SNP | Silent | UCEC |
| 268 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 326 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 327 | C → Y | 0.002020 | SNP | Missense Mutation | PRAD |
| 346 | C → Y | 0.002427 | SNP | Missense Mutation | BLCA |
| 396 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 503 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 514 | C → C | 0.001887 | SNP | Silent | UCEC |
| 571 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 599 | C → F | 0.002141 | SNP | Missense Mutation | SKCM |
| 617 | W → C | 0.001887 | SNP | Missense Mutation | UCEC |