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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q922D8 Mthfd1 C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) … Mus musculus (Mouse) 935 aa

Protein Details: Q922D8 (Mthfd1)

Protein Information
AccessionQ922D8
Protein NamesC-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]
Gene SymbolMthfd1
OrganismMus musculus (Mouse)
Length935 aa
IsoformsNo isoforms
Related PMIDs 28526873 29660268 34884899 35358180 37925639
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAPAGILNGK11LVSAQIRDRL21KNQVTRMQEQ31VPGFTPGLAI41LQVGDRDDSN
51-10051LYINVKLKAA61EEIGIKATHI71KLPRTSTESE81VLKYVISLNE91DASVHGFIVQ
101-150101LPLDSENSIN111TEAVINAIAP121EKDVDGLTSV131SAGKLARGDL141NDCFIPCTPK
151-200151GCLELIKEAG161VQIAGRHAVV171VGRSKIVGAP181MHDLLLWNNA191TVTTCHSKTA
201-250201NLDKEVNKGD211ILVVATGQPE221MVKGEWIKPG231AVVIDCGINY241VPDDTKPNGR
251-300251KVVGDVAYDE261AKERASFITP271VPGGVGPMTV281AMLMQSTVES291AQRFLQKFKP
301-350301GKWTIQYNKL311NLKTPVPSDI321AISRSCKPKL331IGNLAREIGL341LTEEVELYGE
351-400351TKAKVLLSAL361DRLKHQPDGK371YVVVTGITPT381PLGEGKSTTT391IGLVQALGAH
401-450401LRQNVFACVR411QPSQGPTFGI421KGGAAGGGYS431QVIPMEEFNL441HLTGDIHAIT
451-500451AANNLVAAAI461DARIFHELTQ471TDKALFNRLV481PSVNGIRKFS491DIQIRRLRRL
501-550501GIEKTDPTTL511TDDEINRFAR521LDIDPETITW531QRVLDTNDRF541LRKITIGQSP
551-600551TEKGHTRTAQ561FDISVASEIM571AVLALTSSLE581DMRERLGRMV591VASSKKGEPI
601-650601SCEDLGVSGA611LTVLMKDAIK621PNLMQTLEGT631PVFVHAGPFA641NIAHGNSSII
651-700651ADRIALKLVG661PEGFVVTEAG671FGADIGMEKF681FNIKCRYSGL691QPHVVVLVAT
701-750701VRALKMHGGG711PTVTAGLPLP721KAYTEEDLDL731VEKGFSNLRK741QIENARMFGV
751-800751PVVVAVNVFK761TDTDAELDLV771SRLSREHGAF781DAVKCTHWAE791GGQGALALAQ
801-850801AVQRASQAPS811SFQLLYDLKL821SIEDKIRIIA831QRIYGADDIE841LLPEAQNKAE
851-900851IYTKQGFGNL861PICMAKTHLS871LSHNPEQKGV881PTGFVLPIRD891IRASVGAGFL
901-935901YPLVGTMSTM911PGLPTRPCFY921DIDLDPETEQ931VNGLF
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
143 SWISSPALM DBPTM CYSMODDB -
Liver (28526873)
MLE (39008777)
-
Deep-Palm: 0.98
147 SWISSPALM DBPTM CYSMODDB Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
Liver (28526873)
MLE (39008777)
-
GPS-Palm: 0.90
Deep-Palm: 0.97
152 -
MLE (39008777)
-
Deep-Palm: 0.94
195 SWISSPALM DBPTM CYSMODDB Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding domain
Liver (28526873)
-
Deep-Palm: 0.52
236 - - -
Deep-Palm: 0.94
326 - - -
Deep-Palm: 0.96
408 SWISSPALM DBPTM CYSMODDB Formate--tetrahydrofolate ligase
Liver (28526873)
-
Deep-Palm: 0.93
602 - - -
Deep-Palm: 0.97
685 - - -
Deep-Palm: 0.58
785 - - -
Deep-Palm: 0.97
863 SWISSPALM DBPTM CYSMODDB Formate--tetrahydrofolate ligase
Liver (28526873)
-
Deep-Palm: 0.96
918 - - -
Deep-Palm: 0.41
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.714
5
Liver
Specificity: 0.714
5/5 (100.0%)
2
Brain
Specificity: 0.286
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine