Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q96FX8 | PERP | p53 apoptosis effector related to … | Homo sapiens (Human) | 193 aa |
Protein Details: Q96FX8 (PERP)
Protein Information
| Accession | Q96FX8 |
|---|---|
| Protein Names | p53 apoptosis effector related to PMP-22 (Keratinocyte-associated protein 1) (KCP-1) (P53-induced protein PIGPC1) (Transmembrane protein THW) |
| Gene Symbol | PERP |
| Organism | Homo sapiens (Human) |
| Length | 193 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MIRCGLACER11CRWILPLLLL21SAIAFDIIAL31AGRGWLQSSD41HGQTSSLWWK
51-10051CSQEGGGSGS61YEEGCQSLME71YAWGRAAAAM81LFCGFIILVI91CFILSFFALC
101-150101GPQMLVFLRV111IGGLLALAAV121FQIISLVIYP131VKYTQTFTLH141ANPAVTYIYN
151-193151WAYGFGWAAT161IILIGCAFFF171CCLPNYEDDL181LGNAKPRYFY191TSA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 4 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.03
|
| 8 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.07
|
| 11 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.20
|
|
| 51 | - | - | - |
Deep-Palm: 0.26
|
|
| 65 | - | - | - |
Deep-Palm: 0.70
|
|
| 83 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.53
|
|
| 91 | - | - | - |
Deep-Palm: 0.30
|
|
| 100 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.80
|
|
| 166 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.14
|
|
| 171 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.59
|
|
| 172 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.68
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
2
LNCaP
Specificity: 0.500
2/2 (100.0%)
2
PC3
Specificity: 0.500
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 34 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 167 | A → _C171del | 0.002976 | DEL | In Frame Del | KIRC |
| 170 | F → C | 0.002506 | SNP | Missense Mutation | COAD |
| 171 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 192 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 171* | C → ? | 0.002545 | SNP | Nonsense Mutation | GBM |